Report on Mini-conference on Sludge Disposal Alternatives in the Ocean off Southern California, 8 September 1976

The purpose of the conference was to review the status of our capability to predict the environmental effects of the disposal of digested sewage sludge in the ocean off the coast of Southern California. At present, the ocean disposal of sewage sludge is prohibited by State and Federal regulations. Ocean disposal of sludge, however, is a complex of many alternative combinations of what, where and how; and the environmental consequences of all such combinations have not yet been determined. There is, in fact, some evidence that at least one environmentally sound mode of sludge disposal in the ocean off the Southern California coast may exist. This is the trapping of sludge in the sediments of deep, nearshore ocean basins. such as the Santa Monica Basin. Details of this method are given in Section 3.3. p. 12. It is the philosophy of the Environmental Quality Laboratory to study and evaluate policy alternatives but not to be an advocate of one alternative or another. Some of the policies studied may be contrary to existing laws or regulations, but it is believed that there is a better chance for improvement in the laws or regulations if alternatives currently outside them are also studied. The conference was sponsored by the Environmental Quality Laboratory in the belief that sufficient information is now available to begin making reasonable estimates of the environmental consequences of existing or alternative ocean disposal methods in order to compare them to land-based disposal methods. The purpose of this report is not to publish the actual proceedings of the conference. but rather to act as a communications aid. It is intended to publicize the issues that were raised at the conference, to give the names and addresses of people who are involved in these issues, and to present abstracts and literature citations. The schedule of the conference is presented in the next section. It is followed by a section containing abstracts of current research by conference attendees along with reference lists supplied by them. The fourth section is a summary of the afternoon discussion sessions. The final section is a list of conference attendees with their mailing addresses

Interview with George and Margaret Isaacson by Andrea L’Hommedieu

Biographical NoteGeorge Steven Isaacson was born in New York on October 20, 1948, and grew up in Auburn, Maine. His father worked in a lumber business in Livermore Falls with his uncles. George was graduated from Bowdoin College and attended law school at the University of Pennsylvania, where he met his future wife, Margaret. After graduating, he clerked for Judge Thomas E. Delahanty and then went to work for a law firm in Portland, Maine. George Mitchell interviewed him for an attorney’s position with Jensen Baird law firm. At the time of this interview, he was a senior partner at Brann and Isaacson in Lewiston, Maine, an adjunct professor at Bowdoin College, and a lecturer at the University of Maine School of Law. Margaret (McGaughey) Isaacson was born in Detroit, Michigan, on May 29, 1948. She lived in New York, attended college in California and law school at the University of Pennsylvania. Margaret practiced law in Boston for four years and then accepted a clerkship with Frank Coffin in Maine. When George Mitchell was appointed U.S. attorney and permitted a third assistant U.S. attorney position, Margaret was hired. At the time of this interview, Margaret had served in the U.S. Attorney’s Office for thirty-two years. SummaryInterview includes discussion of: George’s childhood in Auburn; growing up Jewish in Auburn; Margaret’s childhood; their meeting in law school; George’s clerkship in Maine; George’s recollections of Mitchell at Jensen Baird; Margaret’s moving to Maine for a clerkship with Frank Coffin and then as assistant U.S. attorney under Mitchell; the U.S. Attorney’s Office and Jim Brannigan; Mitchell’s management style; anecdote about Margaret’s working on drug cases with Mitchell; Mitchell’s appointment to federal judgeship; Mitchell’s 1974 gubernatorial campaign; Mitchell and rumors about the Supreme Court; Mitchell’s talent for litigation and his process in preparing a case; and Bowdoin College

Reactive Boundary Conditions as Limits of Interaction Potentials for Brownian and Langevin Dynamics

A popular approach to modeling bimolecular reactions between diffusing molecules is through the use of reactive boundary conditions. One common model is the Smoluchowski partial absorption condition, which uses a Robin boundary condition in the separation coordinate between two possible reactants. This boundary condition can be interpreted as an idealization of a reactive interaction potential model, in which a potential barrier must be surmounted before reactions can occur. In this work we show how the reactive boundary condition arises as the limit of an interaction potential encoding a steep barrier within a shrinking region in the particle separation, where molecules react instantly upon reaching the peak of the barrier. The limiting boundary condition is derived by the method of matched asymptotic expansions, and shown to depend critically on the relative rate of increase of the barrier height as the width of the potential is decreased. Limiting boundary conditions for the same interaction potential in both the overdamped Fokker-Planck equation (Brownian Dynamics), and the Kramers equation (Langevin Dynamics) are investigated. It is shown that different scalings are required in the two models to recover reactive boundary conditions that are consistent in the high friction limit where the Kramers equation solution converges to the solution of the Fokker-Planck equation.Comment: 23 pages, 2 figure

What Drives Car Attitudes: An Analysis of How Demographics and Environmental Views Relate to Car Attitudes

Successfully marketing new, clean, car technologies to consumers requires an advertising strategy that fits consumers’ priorities and attitudes towards cars. We created a survey to study how attitudes towards cars are associated with demographics and environmental views. Our study examined car preferences and environmental concerns of a sample of Gettysburg College students in comparison to a national sample obtained from Amazon’s Mechanical Turk. Overall, we concluded that environmental beliefs are a significantly better prediction of car behaviors than demographics. We found that on average people would pay more for a car with a higher fuel economy, but not enough to cover the higher price of newer, cleaner technologies, such as hybrid cars. Gettysburg College students’ environmental concern scores were significantly higher on average than that of the general American population. Survey respondents from both samples supported devoting more research and resources to hybrid, electric, and biofuel technologies. However, in regards to their personal purchases they ranked safety and other qualities of the car as higher priorities than greenhouse gas emissions or fuel economy. According to our results, marketing electric cars as safe and reliable is a better strategy than marketing their high fuel economy

Arousal regulates frequency tuning in primary auditory cortex.

Changes in arousal influence cortical sensory representations, but the synaptic mechanisms underlying arousal-dependent modulation of cortical processing are unclear. Here, we use 2-photon Ca2+ imaging in the auditory cortex of awake mice to show that heightened arousal, as indexed by pupil diameter, broadens frequency-tuned activity of layer 2/3 (L2/3) pyramidal cells. Sensory representations are less sparse, and the tuning of nearby cells more similar when arousal increases. Despite the reduction in selectivity, frequency discrimination by cell ensembles improves due to a decrease in shared trial-to-trial variability. In vivo whole-cell recordings reveal that mechanisms contributing to the effects of arousal on sensory representations include state-dependent modulation of membrane potential dynamics, spontaneous firing, and tone-evoked synaptic potentials. Surprisingly, changes in short-latency tone-evoked excitatory input cannot explain the effects of arousal on the broadness of frequency-tuned output. However, we show that arousal strongly modulates a slow tone-evoked suppression of recurrent excitation underlying lateral inhibition [H. K. Kato, S. K. Asinof, J. S. Isaacson, Neuron, 95, 412-423, (2017)]. This arousal-dependent "network suppression" gates the duration of tone-evoked responses and regulates the broadness of frequency tuning. Thus, arousal can shape tuning via modulation of indirect changes in recurrent network activity

Olfactory Reciprocal Synapses: Dendritic Signaling in the CNS

AbstractSynaptic transmission between dendrites in the olfactory bulb is thought to play a major role in the processing of olfactory information. Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic dendrodendritic inhibition back onto mitral dendrites. We examined the mechanisms governing reciprocal dendritic transmission in rat olfactory bulb slices. We find that NMDA receptors play a critical role in this dendrodendritic inhibition. As with axonic synapses, the dendritic release of fast neurotransmitters relies on N- and P/Q-type calcium channels. The magnitude of dendrodendritic transmission is directly proportional to dendritic calcium influx. Furthermore, recordings from pairs of mitral cells show that dendrodendritic synapses can mediate lateral inhibition independently of axonal action potentials

Pleading Scienter Under Section 21D(b)(2) of the Securities Exchange Act of 1934: Motive, Opportunity, Recklessness, and the Private Securities Litigation Reform Act of 1995

This Article discusses conflicting case law regarding the standard for pleading scienter under section 21D(b)(2) of the Securities Exchange Act of 1934. The Private Securities Litigation Reform Act of 1995 (PSLRA) enacted section 21(b)(2). Several courts found that the standard for pleading scienter under section 21(b)(2) was the same as the Second Circuit requirement to show a strong inference of scienter in the pleadings. Other courts found that the pleading requirement in section 21(b)(2) was heightened above the Second Circuit standard. This Article reviews the text and structure of section 21(b)(2) and the conflicting case law, in order to determine the correct pleading standard. The authors conclude that the Second Circuit standard is the standard that Congress intended with the passage of the PSLRA

Ambiguity and Inconsistencies in Mathematics Spoken in the Classroom: The Need for Teacher Training and Rules for Communication of Mathematics

Mathematics has the potential for being spoken ambiguously. This is problematic for many students, in particular those who have disabilities that inhibit processing of printed material. This paper documents the magnitude of potential ambiguity arising from textbooks and provides a measure of the degree to which potential ambiguity is actualized through teachers’ speech. Inconsistency among teachers in speaking mathematics is also documented. Evidence is provided that teachers are not adequately aware of ambiguity in speaking mathematics and that they believe that they should have training regarding ambiguity in communication of mathematics and how to speak mathematics non-ambiguously