67 research outputs found
Role of dynamical particle-vibration coupling in reconciliation of the puzzle for spherical proton emitters
It has been observed that decay rate for proton emission from
single particle state is systematically quenched compared with the prediction
of a one dimensional potential model although the same model successfully
accounts for measured decay rates from and states. We
reconcile this discrepancy by solving coupled-channels equations, taking into
account couplings between the proton motion and vibrational excitations of a
daughter nucleus. We apply the formalism to proton emitting nuclei
Re to show that there is a certain range of parameter set of the
excitation energy and the dynamical deformation parameter for the quadrupole
phonon excitation which reproduces simultaneously the experimental decay rates
from the 2, 3 and 1 states in these nuclei.Comment: RevTex, 12 pages, 4 eps figure
Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic.
'No abstract
Approximate Bisimulations for Sodium Channel Dynamics
Abstract. This paper shows that, in the context of the Iyer et al. 67-variable cardiac myocycte model (IMW), it is possible to replace the detailed 13-state continuous-time MDP model of the sodium-channel dy-namics, with a much simpler Hodgkin-Huxley (HH)-like two-state sodium-channel model, while only incurring a bounded approximation error. The technical basis for this result is the construction of an approximate bisim-ulation between the HH and IMW channel models, both of which are input-controlled (voltage in this case) continuous-time Markov chains. The construction of the appropriate approximate bisimulation, as well as the overall result regarding the behavior of this modified IMW model, in-volves: (1) The identification of the voltage-dependent parameters of the m and h gates in the HH-type channel, based on the observations of the IMW channel. (2) Proving that the distance between observations of the two channels never exceeds a given error. (3) Exploring the sensitivity of the overall IMW model to the HH-type sodium-channel approximation. Our extensive simulation results experimentally validate our findings, for varying IMW-type input stimuli
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Localisation of aminopeptidase activities in the central and peripheral nervous system of Helix aspersa by fluorescence histochemistry.
Visual detection of peptidase activity using fluorogenic substrates in a microtiter plate assay.
Biological activity and receptor binding properties of some C-terminally modified analogues of FMRFamide.
Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity
No difference indicated in electroencephalographic power spectral analysis in 3- and 6-month-old infants fed soy- or milk-based formula
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