Proton magnetic resonance of the bovine spleen green heme-protein

AbstractThe ferric spleen green heme-protein exhibits hyperfine-shifted proton resonances between 90 and 20 ppm for the high-spin resting form and the chloride complex, and between 46 and −9.4 ppm for the low-spin nitrite complex. The proton NMR spectral profile of the enzyme is similar to that of lactoperoxidase, but different from those of common heme-proteins. The appearance of a resonance at 76 ppm in the ferrous enzyme shows the presence of a proximal histidine residue linked to the iron. The proton relaxation rates of bulk water indicate that chloride binds to the sixth position of the iron in the chloride complex of the enzyme

Research and Development of quantitative CBF measurement with MRI

科学研究費補助金研究成果報告書研究種目: 基盤研究(C)研究期間: 2002～2004課題番号: 14571309研究代表者: 椎野 顯彦（滋賀医科大学・医学部・教授）研究分担者: 犬伏 俊郎（滋賀医科大学・MR医学総合研究センター・教授

ウサギ肝障害モデルにおける ^<31>PーNMRによる膜リン脂質代謝動態の研究

科学研究費補助金研究成果報告書研究種目: 一般研究(C)研究期間: 1990～1990課題番号: 02807237研究代表者: 森川 茂廣（滋賀医科大学・医学部・助手）研究分担者: 犬伏 俊郎（滋賀医科大学・医学部・教授

Device development to measure cellular activity in brain

科学研究費補助金研究成果報告書研究種目: 国際学術研究研究期間: 1997～1998課題番号: 09044287研究代表者: 犬伏 俊郎（滋賀医科大学・分子神経生物学研究センター・教授）研究分担者: 森川 茂広（滋賀医科大学・分子神経生物学研究センター・助教授）研究分担者: 椎野 顯彦（滋賀医科大学・医学部・助手

NMR-spectrophotometer integrated device to monitor neuronal activity

科学研究費補助金研究成果報告書研究種目: 基盤研究(B)研究期間: 1999～2000課題番号: 11694262研究代表者: 犬伏 俊郎（滋賀医科大学・分子神経科学研究センター・教授）研究分担者: 森川 茂広（滋賀医科大学・分子神経科学研究センター・助教授）研究分担者: 椎野 顯彦（滋賀医科大学・医学部・講師

Non-invasive analyses of brain metabolic function in dementia

科学研究費補助金研究成果報告書研究種目: 基盤研究(A)研究期間: 1998～2000課題番号: 10358017研究代表者: 犬伏 俊郎（滋賀医科大学・分子神経科学研究センター・教授）研究分担者: 森川 茂広（滋賀医科大学・分子神経科学研究センター・助教授）研究分担者: 椎野 顯彦（滋賀医科大学・医学部・助手

Realization of Real-Time MR Image Guided Surgery Combined with High-Resolution 3D Image Navigation

科学研究費補助金研究成果報告書研究種目: 基盤研究(C)研究期間: 2001～2002課題番号: 13671227研究代表者: 森川 茂廣（滋賀医科大学・分子神経科学研究センター・助教授）研究分担者: 犬伏 俊郎（滋賀医科大学・分子神経科学研究センター・教授）研究分担者: 椎野 顯彦（滋賀医科大学・医学部・講師）研究分担者: 来見 良誠（滋賀医科大学・医学部・講師

Correlation between musculoskeletal structure of the hand and primate locomotion: Morphometric and mechanical analysis in prehension using the cross- and triple-ratios

Biometric ratios of the relative length of the rays in the hand have been analyzed between primate species in the light of their hand function or phylogeny. However, how relative lengths among phalanges are mechanically linked to the grasping function of primates with different locomotor behaviors remains unclear. To clarify this, we calculated cross and triple-ratios, which are related to the torque distribution, and the torque generation mode at different joint angles using the lengths of the phalanges and metacarpal bones in 52 primates belonging to 25 species. The torque exerted on the finger joint and traction force of the flexor tendons necessary for a cylindrical grip and a suspensory hand posture were calculated using the moment arm of flexor tendons measured on magnetic resonance images, and were compared among\ua0Hylobates\ua0spp.,\ua0Ateles\ua0sp., and\ua0Papio hamadryas. Finally, the torques calculated from the model were validated by a mechanical study detecting the force exerted on the phalanx by pulling the digital flexor muscles during suspension in these three species. Canonical discriminant analysis of cross and triple-ratios classified primates almost in accordance with their current classification based on locomotor behavior. The traction force was markedly reduced with flexion of the MCP joint parallel to the torque in brachiating primates; this was notably lower in the terrestrial quadrupedal primates than in the arboreal primates at mild flexion. Our mechanical study supported these features in the torque and traction force generation efficiencies. Our results suggest that suspensory or terrestrial quadrupedal primates have hand structures that can exert more torque at a suspensory posture, or palmigrade and digitigrade locomotion, respectively. Furthermore, our study suggests availability of the cross and triple-ratios as one of the indicators to estimate the hand function from the skeletal structure