26 research outputs found
Flagellin-Induced Corneal Antimicrobial Peptide Production and Wound Repair Involve a Novel NF-κB–Independent and EGFR-Dependent Pathway
- Author
- A Aderem
- A Kumar
- A Kumar
- A Kumar
- A Verma
- AK Mayer
- AK Randhawa
- AM McDermott
- Ashok Kumar
- AT Gewirtz
- CJ Sanders
- CP Blobel
- E Andersen-Nissen
- E DiMango
- EA Miao
- FS Yu
- Fu-Shin Yu
- G Diamond
- H Kumar
- HC Ramos
- HP Jia
- IK Gipson
- J Du
- J Tseng
- J Yin
- J Yin
- J Zhang
- J Zhang
- Jeevan Jyot
- JG Rheinwald
- JL Koff
- K Liu
- K Roepstorff
- KD Smith
- KH Cheng
- KP Xu
- KP Xu
- KS Michelsen
- L Franchi
- L Zhu
- LD Hazlett
- LD Hazlett
- LG Burdelya
- M Feldman
- M Ni
- M Sibilia
- M Vijay-Kumar
- MT Abreu
- N McNamara
- Nan Gao
- Neeraj Vij
- R Medzhitov
- R Shaykhiev
- S Higashiyama
- S Higashiyama
- S Lyons
- S Naik
- S Uematsu
- SH Rhee
- ST Holgate
- T Weichhart
- TS Steiner
- TS Steiner
- V Feuillet
- VL Campodonico
- XL Rudner
- Y Bhattacharjee
- Y Lai
- Z Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/02/2010
- Field of study
The bacterial protein flagellin plays a major role in stimulating mucosal surface innate immune response to bacterial infection and uniquely induces profound cytoprotection against pathogens, chemicals, and radiation. This study sought to determine signaling pathways responsible for the flagellin-induced inflammatory and cytoprotective effects on human corneal epithelial cells (HCECs).Flagellin purified from Pseudomonas aeruginosa (strain PAK) or live bacteria were used to challenge cultured HCECs. The activation of signaling pathways was assessed with Western blot, and the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs) were measured with ELISA and dot blot, respectively. Effects of flagellin on wound healing were assessed in cultured porcine corneas. L94A (a site mutation in TLR5 binding region) flagellin and PAK expressing L94A flagellin were unable to stimulate NF-kappaB activation, but were potent in eliciting EGFR signaling in a TGF-alpha-related pathway in HCECs. Concomitant with the lack of NF-kappaB activation, L94A flagellin was ineffective in inducing IL-6 and IL-8 production in HCECs. Surprisingly, the secretion of two inducible AMPs, LL-37 and hBD2, was not affected by L94A mutation. Similar to wild-type flagellin, L94A induced epithelial wound closure in cultured porcine cornea through maintaining EGFR-mediated signaling.Our data suggest that inflammatory response mediated by NF-kappaB can be uncoupled from epithelial innate defense machinery (i.e., AMP expression) and major epithelial proliferation/repair pathways mediated by EGFR, and that flagellin and its derivatives may have broad therapeutic applications in cytoprotection and in controlling infection in the cornea and other mucosal tissues
Immunological Basis for the Gender Differences in Murine Paracoccidioides brasiliensis Infection
- Author
- A Cernetich
- A Dutt
- A Gonzalez
- A Restrepo
- A Restrepo
- A Sano
- AA Azenabor
- AF Flavia Popi
- AM Tobon
- Anália Sulamita Casabona-Fortunato
- AP Moreira
- Aric Gregson
- AS Karhawi
- BH Aristizabal
- BH Aristizabal
- C Fava Netto
- Camila Figueiredo Pinzan
- CC Romano
- CM Starr
- CW Roberts
- CW Roberts
- D de Mattos Grosso
- DA Stevens
- DR Rodrigues
- DS Loose
- E Brummer
- E Karpuzoglu
- E Karpuzoglu
- E Karpuzoglu
- E Karpuzoglu-Sahin
- E Karpuzoglu-Sahin
- ESM Ramos
- Fernanda Caroline Carvalho
- G Benard
- G San-Blas
- GR Hayes
- H Snider
- HG Muchmore
- HJ You
- HS Fox
- IK Vijay
- JG McEwen
- JL Burg
- JT Souto
- KC Coltri
- KC Coltri
- L Ganiko
- LC Franco M
- LM Singer-Vermes
- Luciana Pereira Ruas
- M Arango
- M Hong
- Maria-Cristina Roque-Barreira
- MC Livonesi
- ME Salazar
- MF Hannah
- NG Mota
- P D'Agostino
- P Sommer
- R Friedl
- R Giraldo
- SA Marques
- SC Wilcoxen
- SJ Oliveira
- SL Klein
- SM Liva
- SS Kashino
- SS Kashino
- TC Chao
- TC Chao
- TC Chao
- TC Chao
- VL Calich
- VL Calich
- VL Calich
- WP Benten
- Y Yamamoto
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
This study aimed to investigate the immunological mechanisms involved in the gender distinct incidence of paracoccidioidomycosis (pcm), an endemic systemic mycosis in Latin America, which is at least 10 times more frequent in men than in women. Then, we compared the immune response of male and female mice to Paracoccidioides brasiliensis infection, as well as the influence in the gender differences exerted by paracoccin, a P. brasiliensis component with carbohydrate recognition property. High production of Th1 cytokines and T-bet expression have been detected in the paracoccin stimulated cultures of spleen cells from infected female mice. In contrast, in similar experimental conditions, cells from infected males produced higher levels of the Th2 cytokines and expressed GATA-3. Macrophages from male and female mice when stimulated with paracoccin displayed similar phagocytic capability, while fungicidal activity was two times more efficiently performed by macrophages from female mice, a fact that was associated with 50% higher levels of nitric oxide production. In order to evaluate the role of sexual hormones in the observed gender distinction, we have utilized mice that have been submitted to gonadectomy followed by inverse hormonal reconstitution. Spleen cells derived from castrated males reconstituted with estradiol have produced higher levels of IFN-γ (1291±15 pg/mL) and lower levels of IL-10 (494±38 pg/mL), than normal male in response to paracoccin stimulus. In contrast, spleen cells from castrated female mice that had been treated with testosterone produced more IL-10 (1284±36 pg/mL) and less IFN-γ (587±14 pg/mL) than cells from normal female. In conclusion, our results reveal that the sexual hormones had a profound effect on the biology of immune cells, and estradiol favours protective responses to P. brasiliensis infection. In addition, fungal components, such as paracoccin, may provide additional support to the gender dimorphic immunity that marks P. brasiliensis infection
Venous endothelial injury in central nervous system diseases
- Author
- A Amberger
- A Compston
- A Ferlini
- A Hamik
- A Minagar
- A Minagar
- A Minagar
- A Rodríguez-Barbero
- AB Lee
- AC Arnold
- AI Ivanov
- Alireza Minagar
- AM Saindane
- AM Youssef
- AT Argaw
- B Ertl-Wagner
- B Schaller
- BK Lal
- C Bawdier-Commander
- C Sainte-Rose
- CC Powell
- CD Sharp
- CD Sharp
- CG Kevil
- CG Kevil
- Chaitanya Vijay Ganta
- CJ MacMillan
- CP Chang
- CW Adams
- CW Adams
- D Carden
- D Franciotta
- D Martino
- D Radak
- D Sander
- DA Hafler
- DG Karahalios
- DJ Callen
- DM Wingerchuk
- E Bazigou
- E Bazigou
- EI Traboulsi
- EL van Agtmaal
- EM Haacke
- EM Haacke
- F Ali
- F Chen
- F Schelling
- FR Haselton
- FR Haselton
- G Pascual
- GV Chaitanya
- H Das
- H Methe
- H Yu
- HG Bohlen
- HJ Kee
- HY Shin
- HY Shin
- HY Shin
- HY Shin
- I Johnston
- I Kim
- IK Koerte
- Ikuo Tsunoda
- J Bujan
- JJ Bergan
- JJ Geurts
- JO Fledderus
- Jonathan S Alexander
- JP Huddleson
- JR Hodges
- JS Alexander
- JS Alexander
- JS Alexander
- K Bouvrée
- K Miyamoto
- K Morita
- K Stefansson
- KM Parmar
- L Cao
- Leonard Prouty
- M Burek
- M Coen
- M Law
- M Liu
- M Nedelmann
- M Pirmohamed
- M Simka
- M Wachtel
- M Wall
- M Wall
- M Zakkar
- MA Anwar
- MC Brodsky
- MJ Lucarelli
- MJ Pollman
- N Kovac
- N Ohnesorge
- NE Volgina
- NG Dela Paz
- NM Akkawi
- NP Young
- P Anand
- P Sansilvestri-Morel
- P Sansilvestri-Morel
- P Sarchielli
- P Zamboni
- P Zamboni
- PJ Pappas
- PT McCollum
- R Kowalewski
- R Magid
- R Meyer-Schwickerath
- R Oklu
- R Oklu
- R Zivadinov
- RA McTaggart
- RC Hubbard
- RH Adams
- RH Adamson
- RH Mellor
- RL Swank
- S Haghjooy Javanmard
- S Lightman
- S Sen-Banerjee
- S SenBanerjee
- S Takase
- S Takase
- S Yura
- SL Lewis
- SM LeVine
- SW Rathbun
- T Engell
- T Engell
- T Fog
- T Ichiyama
- T Jacob
- T Ono
- T Putnam
- TC Lee
- TJ Kalogeris
- TJ Putnam
- TJ Putnam
- V Wong
- VH Perry
- W Craelius
- W Wu
- WG Mayhan
- X Wang
- Y Fang
- Y Ge
- Y Karmon
- Y Yang
- Z Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhandari A. V.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bianchi A.
- Bilenko I. A.
- Bilicki Maciej
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Biscans S.
- Bischi M.
- Biscoveanu Andrea Sylvia
- Bisht A.
- Bitossi M.
- Blackburn Kent
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- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bondarescu Ruxandra
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- Bossilkov V.
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- BRANCHESI Marica
- Breschi Matteo
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- Brillet A.
- Brinkmann M.
- Brockill P.
- Brooks Aidan
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- Brunett S.
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- Bryant J.
- Bucci F.
- Buchanan J.
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- Bulten H. J.
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- Burtnyk K.
- Buscicchio Riccardo
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- Bustillo J. Calderón
- Buy Christelle
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- C. Utina Andrei
- Cabourn Davies Gareth
- Cabras Giuseppe
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- Carlin Julian
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- Castaldi G.
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- Caudill S.
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- Cella Giancarlo
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- Chaibi W.
- Chalathadka Subrahmanya Shreevathsa
- Chan C.
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- Chandra K.
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- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
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- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
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- Chaty Sylvain
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- Christensen Nelson
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- Clasey Essick Reed
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- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
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- Creighton Jolien
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- d'Emilio V.
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- de rossi camilla
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- de Souza Melo S. Assis
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- Degallaix Jerome
- Del Pozzo W.
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- di giovanni Fabrizio
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- Diamond P. Z.
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- Hellman Frances
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- Watada K.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weller C. M.
- Weller Robert
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- Woehler J.
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- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
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- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
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- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zeeshan M.
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- Zerrad M.
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- Zhang Jue
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- Zhang Rui
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- Zhang Ya
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Carbohydrates of influenza virus. Structure of the oligosaccharides linked to asparagines 406 and 478 in the hemagglutinin of fowl plague virus, strain dutch
- Author
- A Kobata
- A Matsumoto
- AG Porter
- AL Tarentino
- CW Ward
- DC Wiley
- H Bj�rndal
- H Halbeek van
- H Niemann
- H Schachter
- IA Wilson
- IA Wilson
- IK Vijay
- J Conchie
- J Kocourek
- J Montreuil
- JFG Vliegenthart
- JH Elder
- K Yamashita
- MLE Bergh
- R Geyer
- R Geyer
- R Geyer
- R Geyer
- R Kornfeld
- RG Webster
- S Diabat�
- S Diabat�
- S Hakomori
- S Takasaki
- T Mizuochi
- TH Plummer
- W Garten
- W Keil
- W Keil
- Y-T Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1987
- Field of study
Effect of physical and chemical conditions on the production of colominic acid by Escherichia coli in a defined medium
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
(R&D of Chinese Firms: Characteristics and Implications)
- Author
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- G Z Albert
- H Grupp
- Hulya Ulku
- Ik Joon Moon
- Jianjun�liu Yang
- Jiatao Li
- Jina Yeo
- Jones Day
- Jonghak Eun
- Ken Shao
- Kiep ?????. 2006a
- Kiep ??????? ?11-03?
- Lenovo
- Min Suk Park
- Oecd
- Prasada Reddy
- Qingjiang Kong
- R Griffith
- Ravi Ramamurti
- S Uscc(u
- Seri(???????). 2011
- Su Yeob Na
- T S Babel
- Vijay Govindarajan
- Wei-Ning Yang
- Xiangjun Si
- Xiaoqing Feng
- Xin Fang
- Yasuyuki Todo
- Yingying Guo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ):Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
- Author
- Adasme Tatiana
- Addamo Lauren
- Addington Jean
- Adery Laura
- Agurto Carla
- Ahmed Uzair
- Ali Munaza
- Allott Kelly
- Alvarez-Jimenez Mario
- Amminger Paul
- Anticevic Alan
- Arango Celso
- Armando Marco
- Asgari-Targhi Ameneh
- Auther Andrea
- Aversa Samantha
- Baek Seon Hwa
- Baker Justin T.
- Bates Kelly
- Bathery Alyssa
- Bayer Johanna M.M.
- Bearden Carrie E.
- Beedham Rebecca
- Bilgrami Zarina
- Billah Tashrif
- Birch Sonia
- Bonoldi Ilaria
- Borders Owen
- Borgatti Renato
- Bouix Sylvain
- Broome Matthew R.
- Brown Lisa
- Bruna Alejandro
- Buccilli Kate
- Byun Andrew Jin Soo
- Cadenhead Kristin S.
- Cahill John
- Calkins Monica E.
- Cannon Tyrone D.
- Carrington Holly
- Carrión Ricardo E.
- Castillo-Passi Rolando I.
- Castro Eduardo
- Cecci Guillermo
- Cetin-Karayumak Suheyla
- Chen Eric Yu Hai
- Chen Justine
- Cheng Nicholas
- Ching Ann Ee
- Cho Kang Ik K.
- Cho Youngsun T.
- Choi Jimmy
- Chung Yoonho
- Clark Scott R.
- Clifford Chloe
- Coleman Michael J.
- Colton Beau Luke
- Contreras Pamela
- Conus Philippe
- Corcoran Cheryl M.
- Cornblatt Barbara A.
- Corral Sebastián
- Cotter David
- D'Alfonso Simon
- Damiani Stefano
- Diaz-Caneja Covadonga M.
- Do Kim
- Done Monica
- Dwyer Dominic
- Ebdrup Bjørn H.
- Ellman Lauren M.
- Ennis Michaela
- Estradé Andrés
- Etuka Brandon Asika
- Fadnavis Shreyas
- Fonteneau Clara
- Formica Melanie
- Furlan Rachel
- Fusar-Poli Paolo
- Galindo Liliana
- Gao Caroline
- Gaspar Pablo A.
- Geljic Mia
- Gerber Carla
- Germano Carmela
- Getachew Ruth
- Glenthøj Louise Birkedal
- Glynn Robert
- Goncalves Mathias
- Gupta Tina
- Gur Raquel E.
- Gur Ruben C.
- Haidar Anastasia
- Hamilton Holly K.
- Harms Michael P.
- Hartmann Jessica
- Hendricks Larry
- Hoftman Gil D.
- Horton Leslie E.
- Hui Christy Lai Ming
- Huynh Kevin
- Jacobs Grace R.
- Jarcho Johanna
- Jeffries Clark
- Ji Jie Lisa
- Jo Anna
- John Omar
- Kahn René S.
- Kambeitz Joseph
- Kambeitz-Ilankovic Lana
- Kane John M.
- Kapur Tina
- Kerins Sarah
- Kerr Melissa
- Keshavan Matcheri S.
- Kesselring Irena
- Kim Honey
- Kim Nicholas
- Kim Sung Wan
- Kinney Kyle
- Kohler Christian G.
- Kotler Elana
- Koutsouleris Nikolaos
- Krcmar Marija
- Kubicki Marek
- Kwon Jun Soo
- Lafanechere Melanie
- Lalousis Paris Alexandros
- Lane Erlend
- Langbein Kerstin
- Langholm Carsten
- Lavoie Suzie
- Lee Clarice
- Lepage Martin
- Lewandowski Kathryn E.
- Liebenthal Einat
- Light Gregory A.
- Lin Eric
- Llerena Joshua
- Mallar Chakravarty M.
- Mamah Daniel
- Mantua Valentina
- Marcy Patricia J.
- Markiewicz Christopher
- Mathalon Daniel H.
- Matnejl Priya
- Maturana Alejandro
- Mavambu Aissata
- Mayol-Troncoso Rocío
- McDonnell Amelia
- McGorry Patrick D.
- McGowan Alessia
- McIlhenny Rebecca
- McLaughlin Danielle
- McQueen Brittany
- Mebrahtu Yohannes
- Mensi Martina
- Mervis Josh
- Mittal Vijay A.
- Morrell Neal
- Murty Vishnu
- Nelson Barnaby
- Nicholas Spero C.
- Ning Lipeng
- Nordentoft Merete
- Nunez Angela
- Omar Mariam
- Partridge Alice
- Pasternak Ofer
- Pearlson Godfrey D.
- Penzel Nora
- Perez Jesus
- Perkins Diana O.
- Phassouliotis Christina
- Pichiecchio Anna
- Poldrack Russell
- Politi Pierluigi
- Polosecki Pablo
- Porter Christian
- Powers Albert R.
- Pratt Danielle N.
- Provenzani Umberto
- Prunier Nicholas
- Rabin Rachel
- Rahimi Eichi Habiballah
- Raj Jasmine
- Rathi Yogesh
- Ray Susan
- Rayner Victoria
- Reichenberg Avraham
- Reinen Jenna
- Reyes Manuel
- Reynolds Kate
- Roalf David R.
- Rogers Jack
- Rossum Inge Winter van
- Ruiz-Yu Bernalyn
- Ruparel Kosha
- Rush Sage
- Sabb Fred W.
- Salinas Cesar
- Santorelli Gennarina
- Schiffman Jason
- Scott Isabelle
- Seitz-Holland Johanna
- Shah Jai L.
- Shenton Martha E.
- Shetty Jashmina
- Smesny Stefan
- Snowball Callum
- Spark Jessica
- Srihari Vinod H.
- Srivastava Agrima
- Stone William S.
- Strauss Gregory P.
- Suen Yi Nam
- Tamayo Zailyn
- Thompson Andrew
- Tod Sophie
- Torous John
- Turetsky Bruce I.
- Turra-Fariña Gabriel
- Upthegrove Rachel
- Valle Daniela
- Vangel Mark
- Veale Simone
- Verma Swapna
- Walsh Barbara C.
- Wang Jijun
- Wannan Cassandra M.J.
- Whitford Thomas
- Whitson Sarah
- Wickham Alana
- Wigman Johanna T.W.
- Wolf Daniel H.
- Wolff Phillip
- Wong Stephanie Ming Yin
- Wood Stephen J.
- Woods Scott W.
- Yao Beier
- Youn Sarah
- Yuen Hok Pan
- Yung Alison R.
- Zamorano Francisco
- Zavaglia Elissa
- Zinberg Jamie
- Zoupou Eirini
- Publication venue
- Publication date
- 01/05/2024
- Field of study
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.</p
Enantioselective Resolution of (R,S)-Carvedilol to (S)-(−)-Carvedilol by Biocatalysts
- Author
- A Diaz-Rodriguez
- AJ Hutt
- BR Malgorzata
- BS Jyoti
- CA Enríquez-Núñez
- DSR Aline
- E Nicole
- E Swetha
- E Swetha
- EJ Elisabeth
- G Vijay
- H Jia
- H-X Jin
- HD Yan
- HJ Arpana
- HR Huang
- IK Dai
- J Maritz
- K Nakamura
- K Srisailam
- L Gagyi
- M Lourdes
- M Suar
- MB Smith
- N Layh
- PDO Carvalho
- Q Hu
- RK Venisetty
- RK Venisetty
- S Bhandarkar
- S Datta
- S Rahime
- S Sergio
- SE Milner
- SH Hu
- T Barth
- T Siodmiak
- VP Sandip
- W Adam
- W Levadoux
- YS Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study