A Kinematic Model for the Narrow-Line Region in NGC 4151

We present a simple kinematic model for the narrow-line region (NLR) of the Seyfert 1 galaxy NGC 4151, based on our previous observations of extended [O III] emission with the Space Telescope Imaging Spectrograph (STIS). The model is similar to a biconical radial outflow model developed for the Seyfert 2 galaxy NGC 1068, except that the bicone axis is tilted much more into our line of sight (40 degrees out of the plane of the sky instead of 5 degrees), and the maximum space velocities are lower (750 km/s instead of 1300 km/s. We find evidence for radial acceleration of the emission-line knots to a distance of 160 pc, followed by deceleration that approaches the systemic velocity at a distance of 290 pc (for a distance to NGC 4151 of 13.3 Mpc). Other similarities to the kinematics of NGC 1068 are: 1) there are a number of high-velocity clouds that are not decelerated, suggesting that the medium responsible for the deceleration is patchy, and 2) the bicone in NGC 4151 is at least partially evacuated along its axis. Together, these two Seyfert galaxies provide strong evidence for radial outflow (e.g., due to radiation and/or wind pressure) and against gravitational motion or expansion away from the radio jets as the principal kinematic component in the NLR.Comment: 31 pages, Latex, includes 11 figures in postscript, Figures 5a,5b,6a,6b in color, to appear in the Astronomical Journa

The Resolved Narrow Line Region in NGC4151

We present slitless spectra of the Narrow Line Region (NLR) in NGC4151 from the Space Telescope Imaging Spectrograph (STIS) on HST, and investigate the kinematics and physical conditions of the emission line clouds in this region. Using medium resolution (~0.5 Angstrom) slitless spectra at two roll angles and narrow band undispersed images, we have mapped the NLR velocity field from 1.2 kpc to within 13 pc (H_o=75 km/s/Mpc) of the nucleus. The inner biconical cloud distribution exhibits recessional velocities relative to the nucleus to the NE and approaching velocities to the SW of the nucleus. We find evidence for at least two kinematic components in the NLR. One kinematic component is characterized by Low Velocities and Low Velocity Dispersions (LVLVD clouds: |v| < 400 km/s, and Delta_v < 130 km/s). This population extends through the NLR and their observed kinematics may be gravitationally associated with the host galaxy. Another component is characterized by High Velocities and High Velocity Dispersions (HVHVD clouds: 400 130 km/s). This set of clouds is located within 1.1 arcsec (~70pc) of the nucleus and has radial velocities which are too high to be gravitational in origin, but show no strong correlation between velocity or velocity dispersion and the position of the radio knots. Outflow scenarios will be discussed as the driving mechanism for these HVHVD clouds.Comment: 38 pages, 14 figures, accepted by ApJ. For higher resolution images see http://www.pha.jhu.edu/~kaiser

Consistency tests of AMPCALCULATOR and chiral amplitudes in SU(3) Chiral Perturbation Theory: A tutorial based approach

Ampcalculator is a Mathematica based program that was made publicly available some time ago by Unterdorfer and Ecker. It enables the user to compute several processes at one-loop (upto $O(p^4)$) in SU(3) chiral perturbation theory. They include computing matrix elements and form factors for strong and non-leptonic weak processes with at most six external states. It was used to compute some novel processes and was tested against well-known results by the original authors. Here we present the results of several thorough checks of the package. Exhaustive checks performed by the original authors are not publicly available, and hence the present effort. Some new results are obtained from the software especially in the kaon odd-intrinsic parity non-leptonic decay sector involving the coupling $G_{27}$. Another illustrative set of amplitudes at tree level we provide is in the context of $\tau$-decays with several mesons including quark mass effects, of use to the BELLE experiment. All eight meson-meson scattering amplitudes have been checked. Kaon-Compton amplitude has been checked and a minor error in published results has been pointed out. This exercise is a tutorial based one, wherein several input and output notebooks are also being made available as ancillary files on the arXiv. Some of the additional notebooks we provide contain explicit expressions that we have used for comparison with established results. The purpose is to encourage users to apply the software to suit their specific needs. An automatic amplitude generator of this type can provide error-free outputs that could be used as inputs for further simplification, and used in varied scenarios such as applications of chiral perturbation theory at finite temperature, density and volume. This can also be used by students as a learning aid in low-energy hadron dynamics.Comment: 25 pages, plain latex, corresponds to version to appear in EPJA, additional ancillary files adde

A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4

The DNA structure-selective endonuclease Mus81-Mms4/Eme1 incises a number of nicked joint molecule substrates in vitro. 3′-flaps are an excellent in vitro substrate for Mus81-Mms4/Eme1. Mutants in MUS81 are synthetically lethal with mutations in the 5′-flap endonuclease FEN1/Rad27 in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Considering the possibility for isoenergetic interconversion between 3′- and 5′- flaps, these data are consistent with the hypothesis that Mus81-Mms4/Eme1 acts on 3′-flaps in vivo. FEN1/Rad27 prefers dually flapped substrates and cleaves in a way that allows direct ligation of the resulting nick in the product duplex. Here we test the activity of Mus81-Mms4 on dually flapped substrates and find that in contrast to FEN1/Rad27, Mus81-Mms4 activity is impaired on such substrates, resulting in cleavage products that do not allow direct religation. We conclude that Mus81-Mms4, unlike FEN1/Rad27, does not prefer dually flapped substrates and is unlikely to function as a 3′-flapase counterpart to the 5′-flapase activity of FEN1/Rad27. We further find that joint molecule incision by Mus81-Mms4 occurs in a fashion determined by the branch point, regardless of the position of an upstream duplex end. These findings underscore the significance of a nick adjacent to a branch point for Mus81-Mms4 incision

Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus

<p>Abstract</p> <p>Background</p> <p>Reactive gliosis has the potential to alter biomechanical properties of the brain, impede neuronal regeneration and affect plasticity. Determining the onset and progression of reactive astrogliosis and microgliosis due to hydrocephalus is important for designing better clinical treatments.</p> <p>Methods</p> <p>Reactive astrogliosis and microgliosis were evaluated as the severity of hydrocephalus increased with age in hydrocephalic H-Tx rats and control littermates. Previous studies have suggested that gliosis may persist after short-term drainage (shunt treatment) of the cerebrospinal fluid. Therefore shunts were placed in 15d hydrocephalic rats that were sacrificed after 6d (21d of age) or after 21d (36d of age). Tissue was processed for Western blot procedures and immunohistochemistry, and probed for the astrocytic protein, Glial Fibrillary Acidic Protein (GFAP) and for microglial protein, Isolectin B4 (ILB4).</p> <p>Results</p> <p>In the parietal cortex of untreated hydrocephalic animals, GFAP levels increased significantly at 5d and at 12d compared to age-matched control rats. There was a continued increase in GFAP levels over control at 21d and at 36d. Shunting prevented some of the increase in GFAP levels in the parietal cortex. In the occipital cortex of untreated hydrocephalic animals, there was a significant increase over control in levels of GFAP at 5d. This trend continued in the 12d animals, although not significantly. Significant increases in GFAP levels were present in 21d and in 36d animals. Shunting significantly reduced GFAP levels in the 36d shunted group. Quantitative grading of immuno-stained sections showed similar changes in GFAP stained astrocytes.</p> <p>Immuno-stained microglia were altered in shape in hydrocephalic animals. At 5d and 12d, they appeared to be developmentally delayed with a lack of processes. Older 21d and 36d hydrocephalic animals exhibited the characteristics of activated microglia, with thicker processes and enlarged cell bodies. Following shunting, fewer activated microglia were present.</p> <p>Histologic examination of the periventricular area and the periaqueductal area showed similar findings with the 21d and 36d animals having increased populations of both astrocytes and microglia which were reduced following shunting with a more dramatic reduction in the long term shunted animals.</p> <p>Conclusion</p> <p>Overall, these results suggest that reactive astrocytosis and microgliosis are associated with progressive untreated ventriculomegaly, but that shunt treatment can reduce the gliosis occurring with hydrocephalus.</p

Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration