NEW CONCEPT OF ETIOPATHOGENESIS OF INFANT'S CHRONIC CONSTIPATION AND TREATMENT PRINCIPLES

Basing upon the study of conjunctive tissue frame and unstriped muscles of colon from autopsy material, as well as analysis of over 2000 clinical observations the authors set forth a new concept of etiopathogenesis of infant's chronic constipations by interpreting the functional disorders as a consequence of genetically determined status of conjunctive tissue frame. principles of conservative therapy and indications to surgery correction are considered.Key words: chronic constipation, etiology and pathogenesis, treatment, lactulose, surgical intervention, children

MEDICAL AND SOCIAL PECULIARITIES OF ORTHOPEDIC PATHOLOGY FORMING IN PRE-SCHOOL CHILDREN

(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(1):177-178

LACTULOSE IN PREOPERATIVE PREPARATION OF CHILDREN WITH DECOMPENSATED TYPE OF CHRONIC COLON STASIS

This article describes the results of estimation of effectiveness of lactulose (Dupfalac) in preoperative preparation of children with decompensated type of chronic colon stasis. Proved, that administration of this medication normalizes such indices of homeostasis as acid-base balance of blood and microbiocenose of colon by 7days. Use of lactulose decreases patient complaints on nausea, vomiting, abdominal pain, weakness in 1.6 times rarely then in group of children using other laxative medications in preoperative preparation.Key words: megacolon syndrome, lactulose, dysbacteriosis, blood acid-base balance.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(1):68-71

ANTICOAGULANT THERAPY FOR CORRECTION OF HEMOREOLOGIC PARAMETERS IN CHILDREN WITH PERTHES DISEASE

The analysis of hemorheological indications at 35 children with II stage of Perthes disease in early school age was made in this paper. The correction methods of hemorheological disorders in case of Perthes disease and way of modern adequate medicament treatment that make the prognosis of disease more predictable and controllable were presented in this work. Key words: Perthes disease, hemostasis, dopplerography, treatment, children. (Pediatric Pharmacology. – 2010; 7(1):72-75

HAEMOSTASIS SYSTEM DISORDERS IN CYSTIC AND NIDAL LIVER IMPAIRMENT IN CHILDREN AND THEIR PHARMACOTHERAPY OPPORTUNITIES

In the event of a cystic and nidal liver impairment, resulting from the dysfunction of hepatocytes, there are certain haemostasis system disturbances. The article analyzes co agulograms of 75 children with cystic and nidal liver impairment in early school age (aged 6–11 year). The article reviews the diagnostic methods for detecting hemostasis disturbances in case of the given pathology and away to duly and adequately enforce the medication correction of these disorders. This method makes the illness forecast more predictable and manageable.Key words: haemostasis, liver, cystic and nidal liver impairment, children

HAEMOSTASIS SYSTEM DISORDERS IN CYSTIC AND NIDAL LIVER IMPAIRMENT IN CHILDREN AND THEIR PHARMACOTHERAPY OPPORTUNITIES

In the event of a cystic and nidal liver impairment, resulting from the dysfunction of hepatocytes, there are certain haemostasis system disturbances. The article analyzes co agulograms of 75 children with cystic and nidal liver impairment in early school age (aged 6–11 year). The article reviews the diagnostic methods for detecting hemostasis disturbances in case of the given pathology and away to duly and adequately enforce the medication correction of these disorders. This method makes the illness forecast more predictable and manageable.Key words: haemostasis, liver, cystic and nidal liver impairment, children

ADMINISTRATION OF LACTULOSE IN COMPLEX PEHABILITATION TREATMENT AFTER RADICAL AND RECONSTRUCTIVE RESTORATIVE SURGERY OF BOWELS IN CHILDREN

The results of treatment of children (n = 64) of 1,5–17 years old, receiving rehabilitation course after reconstructive — restorative surgery of bowels are presented in this article. It was shown, that prolonged (1 month and more) administration of lactulose (Duphalac) results in improvement of motor and evacuation function of bowel, and decreases «sensor inability» of reduced parts of bowel. As a result, lactulose stimulates functioning of «obturative apparatus of neoampula» (voluntary evacuation, retention of intestinal contents), that favors to increase of quality of life and social rehabilitation of children in outlying post surgical period.Key words: children, post surgical rehabilitation, «idiopathic megacolon»syndrome, Hirschsprung's disease, anorectal malformations,lactulose.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(2):34-37)</span

HEMOSTATIC SYSTEM DISORDERS IN CHILDREN WITH HYDRONEPHROSIS AND WAYS OF DRUG THERAPY

In hydronephrosis, dysplasia of connective tissue results in hemostatic system disorders manifesting themselves as hemorrhagic mesenchimal dysplasia. The article analyses the coagulograms of 63 children with renal hydronephrosis in pre-school age. The work reviews the methods of diagnosing hemostatic disorders in moderate and severe dysplasia of renal parenchyma and ways of modern adequate drug therapy for these conditions. This method makes a prognosis of the disease more predictable and manageable.Key words: hydronephrosis, dysplasia, kidneys, children

CLINICAL EFFECTIVENESS OF OSMOTIC LAXATIVE DRUGS IN EARLY POSTOPERATIVE PERIOD IN CHILDREN WITH CHRONIC COLON STASIS

The clinical effectiveness of osmotic laxative drugs based on lactulose in restoration of gastrointestinal tract function in early postoperative period after transanal interventions and laparoscopic operations in 53 children 2–17 years old was studied. All patients had non-functional (cologenic and proctogenic) constipation. Patients underwent full-thickness laparoscopic or transanal biopsy due to suspicion of gastrointestinal malformation presence. Children from base group (n = 28) used lactulose (Duphalac) from the second day of postoperative period (dose complied with the age) once daily, in the morning. The control group (n = 25) received subcutaneous or intramuscular proserinum for the stimulation of peristalsis. Blood tests with serum potassium control were performed on 2nd and 4th day. The study showed clinical effectiveness of lactulose in treatment of postoperational hypotonic constipation in children with colon malformations. Key words: children, gastrointestinal malformations, postoperative period, chronic constipation, lactulose.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(1):122-125