Postoperative gastric ileus

Gastric emptying was measured in healthy, trained, unanesthetized dogs before and after surgical manipulation of the intestine and/or treatment with bretylium. Gastric content was found to decline exponentially with time. The pattern of emptying could be defined by the volume remaining in the stomach 10 minutes after the start of feeding and by the slope of the exponential decline in volume of the contents (the rate of gastric emptying). Laparotomy with intestinal manipulation induced gastric retention, but laparotomy alone (sham operation) did not change the rate of gastric emptying. Bretylium, an adrenergic blocking drug, suppressed the postoperative gastric ileus without significantly altering gastric emptying in control animals. Our observations support the classical assumption of a sympathetic hyperactivity during postoperative ileus and suggest that adrenergic blocking agents may be useful in the treatment of paralytic ileus. © 1973 Medical Department Harper & Row, Publishers, Inc.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines

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6-[18F]Fluorodopamine positron emission tomographic scanning in the assessment of cardiac sympathoneural function - studies in normal humans

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Different relationships of spillover to release of norepinephrine in human heart, kidneys, and forearm

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Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes

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Differential inhibition of neuronal and extraneuronal monoamine oxidase

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