19 research outputs found
ΠΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π²Π΅ΡΡ Π½ΠΈΡ Π΄ΡΡ Π°ΡΠ΅Π»ΡΠ½ΡΡ ΠΏΡΡΠ΅ΠΉ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ
Bronchial asthma (BA) is a systemic allergic disease and is associated with upper respiratory tract (URT) pathology. In recent years, attention was focused on allergic diseases multimorbidity, while the spectrum of URT pathology in children with BA is not characterized enough. Objective of the research - to study the structure of URT pathology in children with atopic BA. Study materials and methods: 358 children with atopic BA were examined, the average age of children was 9,91 (9,47, 10,35) years, of which 67,9% were boys (192/358), and 108 children with nasal breathing disorders, comparable in age and sex, but without BA. In addition to the standard all - clinical, allergological, functional examination, all patients underwent video endoscopic examination of the nasal cavity and nasopharynx. Results: Π°Π children with BA were diagnosed with allergic rhinitis (AR) and/ or allergic rhinosinusitis (ARS) with a predominance of persistent forms. The Β«isolatedΒ» course of AR/ARS occurred in 11,7% (42/358) of patients; other children had nasal symptoms due to a combination of AR/ARS with other variants of URT pathology. Pharyngeal tonsilhypertrophy occurred in 61,2% (219/358) of patients, hypertrophic rhinitis - in 9,2% (33/358) of children with BA, nasal architectonics disorders were diagnosed in 50% (179/358) of patients. The combination of two nosological variants of nose pathology occurred in 47,8% (117/358) of patients with BA; 40,5% (145/358) of children with BA had multimorbidity of the nasal pathology - a combination of three or more nosological units. Conclusion: for children with atopic BA and nasal symptoms often have combined and multimorbid forms of URT pathology. Verification of nasal obstruction causes allows to individualize therapy for patients with BA and minimize negative impact of URT pathology on BA course.ΠΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ° (ΠΠ) ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΌ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ ΠΈ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π° Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ Π²Π΅ΡΡ
Π½ΠΈΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ (ΠΠΠ). Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ Π°ΠΊΡΠ΅Π½ΡΠΈΡΡΠ΅ΡΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΠΌΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠΏΠ΅ΠΊΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΈΠ·ΡΡΠΈΡΡ ΡΡΡΡΠΊΡΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΠ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 358 Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΠ, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ Π΄Π΅ΡΠ΅ΠΉ ΡΠΎΡΡΠ°Π²ΠΈΠ» 9,91 (9,47; 10,35) Π»Π΅Ρ, ΠΈΠ· Π½ΠΈΡ
ΠΌΠ°Π»ΡΡΠΈΠΊΠΎΠ² 67,9% (192/358), Π° ΡΠ°ΠΊΠΆΠ΅ 108 Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΆΠ°Π»ΠΎΠ±Π°ΠΌΠΈ Π½Π° Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π½ΠΎΡΠΎΠ²ΠΎΠ³ΠΎ Π΄ΡΡ
Π°Π½ΠΈΡ, ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡΡ
ΠΏΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΡ ΠΈ ΠΏΠΎΠ»Ρ, Π½ΠΎ Π½Π΅ ΠΈΠΌΠ΅Π²ΡΠΈΡ
ΠΠ. ΠΠΎΠΌΠΈΠΌΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Π²ΠΈΠ΄Π΅ΠΎΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΡΡΠΈ Π½ΠΎΡΠ° ΠΈ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Ρ Π²ΡΠ΅Ρ
Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ Π±ΡΠ» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΈΡ (ΠΠ ) ΠΈ/ΠΈΠ»ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΈΡ (ΠΠ Π‘) Ρ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΡΠΈΡΡΠΈΡΡΡΡΠΈΡ
ΡΠΎΡΠΌ. Β«ΠΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅Β» ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΠ /ΠΠ Π‘ ΠΈΠΌΠ΅Π»ΠΎ ΠΌΠ΅ΡΡΠΎ Ρ 11,7% (42/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Ρ ΠΎΡΡΠ°Π»ΡΠ½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π½Π°Π·Π°Π»ΡΠ½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ Π±ΡΠ»ΠΈ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ΠΌ ΠΠ /ΠΠ Π‘ Ρ ΠΈΠ½ΡΠΌΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ. ΠΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡ Π³Π»ΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΌΠΈΠ½Π΄Π°Π»ΠΈΠ½Ρ ΠΈΠΌΠ΅Π»Π° ΠΌΠ΅ΡΡΠΎ Ρ 61,2% (219/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π³ΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΈΡ - Ρ 9,2% (33/358) Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ, Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π°ΡΡ
ΠΈΡΠ΅ΠΊΡΠΎΠ½ΠΈΠΊΠΈ Π½ΠΎΡΠ° Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ Ρ 50% (179/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ Π΄Π²ΡΡ
Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π½ΠΎΡΠ° ΠΈΠΌΠ΅Π»ΠΎ ΠΌΠ΅ΡΡΠΎ Ρ 47,8% (117/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ, Ρ 40,5% (145/358) Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ Π±ΡΠ»Π° ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΠΌΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΡ Π½Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ - ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΡΡΠ΅Ρ
ΠΈ Π±ΠΎΠ»Π΅Π΅ Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΅Π΄ΠΈΠ½ΠΈΡ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: Π΄Π»Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΠ ΠΈ Π½Π°Π·Π°Π»ΡΠ½ΡΠΌΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Ρ ΡΠΎΡΠ΅ΡΠ°Π½Π½ΡΠ΅ ΠΈ ΠΌΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ. ΠΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΡΠΈΡΠΈΠ½ Π½Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ ΠΈ Π½ΠΈΠ²Π΅Π»ΠΈΡΠΎΠ²Π°ΡΡ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΠ
Thymic stromal lymphopoietin as a predictor of hypertrophic changes in the nasal mucosa in children with atopic bronchial asthma and allergic rhinitis
Th2-dependent allergic inflammation in patients with bronchial asthma (BA) and allergic rhinitis (AR) can be associated with nasal mucosa remodeling, accompanied by hypertrophic and hyperplastic processes. Thymic stromal lymphopoietin (TSLP) is a key cytokine produced by epithelial cells and is actively involved in allergic inflammation. Objective of the research: to study TSLP content in nasal secretion of children with atopic BA and AR. Materials and methods: in 43 patients aged 4-17 years with atopic BA and AR, nasal mucosa state was assessed using rhino-endoscopy and TSLP content in nasal secretion by the enzyme immunoassay. Results: hypertrophic or polypouschanges in the nasal mucosa and/or paranasal sinuses were detected in 30% (13/43) of patients. TSLP content in the nasal secretion in these patients was 908, 5 [48, 9; 2098, 7] pg/mg, which is statistically significantly higher than in patients with BA and AR without sinonasal hypertrophy (132, 3 [4, 2; 325, 9] pg/mg, p=0, 036). AR exacerbation was accompanied by a statistically significant increase of TSLP content in the nasal secret compared with the remission period (p=0, 002). Conclusion: hypertrophic changes in the nasal mucosa are accompanied by a statistically significant increase of TSLP content in the nasal secret in children with atopic BA and AR, which allows to consider this biomarker as a potential non-invasive predictor of pathological airway remodeling in patients with chronic allergic airway inflammation. Β© Springer Nature Switzerland AG 2020
The effect of nasal microbiota on the level of total immunoglobulin e in blood serum of children with bronchial asthma
Objective of the research: to study the relationship between the level of total IgE in serum and the nature of the nasal microbiota composition in children with bronchial asthma (BA). Materials and methods: 332 patients with BA were examined, mean age 10,34Β±0,4 years, 72% boys (239/332), the levels of total IgE and IgA, IgM, IgG in blood serum were determined, the composition of the nasal microbiota was studied by culture method. Results: 21,7% (72/332) of children had no St. aureus and St. epidermidis and other conditionally pathogenic flora in nasal microbiota; in 74,1% (246/332) of children S. aureus or St. epidermidis was revealed, in 40,7% (135/332) of them St. aureus was isolated; in 4,2% (14/332) another conditionally pathogenic microflora was found. The level of total IgE in blood serum in patients who had St. aureus in nasal microbiota was the highest and amounted to 218 [172,5; 264,3] IU/ml (p=0,002). Conclusion: St. aureus on the nasal mucosa of the upper respiratory tract in children with BA is accompanied by a higher level of total IgE in blood serum. Β© 2020, Pediatria Ltd.. All rights reserved
Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control
Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD. All patients had AR/ARS; in 76.3% (63/82) of children, UAP had a multimorbid character with the presence of NOD. Significant correlations were found between ACQ-5 and TNSS (R=0.40, p<0.0001) and ACQ-5 and SNOT-20 (R=0.42, p<0.0001). Correlations between TNSS/ACQ-5 and SNOT-20/ACQ-5 were higher in patients who do not have a combination of AR/ARS with NOD (R=0.67, p=0.0012; R=0.50, p=0.022, resp.) than in patients who have AR/ARS combined with NOD (R=0.30, p=0.015; R=0.26, p=0.04, resp.). Thus, the association of BA control level with the expression of nasal and synonasal symptoms is higher in children who do not have multimorbid UAP. Β© 2018 T. I. Eliseeva et al
ΠΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π²Π΅ΡΡ Π½ΠΈΡ Π΄ΡΡ Π°ΡΠ΅Π»ΡΠ½ΡΡ ΠΏΡΡΠ΅ΠΉ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ
Bronchial asthma (BA) is a systemic allergic disease and is associated with upper respiratory tract (URT) pathology. In recent years, attention was focused on allergic diseases multimorbidity, while the spectrum of URT pathology in children with BA is not characterized enough. Objective of the research - to study the structure of URT pathology in children with atopic BA. Study materials and methods: 358 children with atopic BA were examined, the average age of children was 9,91 (9,47, 10,35) years, of which 67,9% were boys (192/358), and 108 children with nasal breathing disorders, comparable in age and sex, but without BA. In addition to the standard all - clinical, allergological, functional examination, all patients underwent video endoscopic examination of the nasal cavity and nasopharynx. Results: Π°Π children with BA were diagnosed with allergic rhinitis (AR) and/ or allergic rhinosinusitis (ARS) with a predominance of persistent forms. The Β«isolatedΒ» course of AR/ARS occurred in 11,7% (42/358) of patients; other children had nasal symptoms due to a combination of AR/ARS with other variants of URT pathology. Pharyngeal tonsilhypertrophy occurred in 61,2% (219/358) of patients, hypertrophic rhinitis - in 9,2% (33/358) of children with BA, nasal architectonics disorders were diagnosed in 50% (179/358) of patients. The combination of two nosological variants of nose pathology occurred in 47,8% (117/358) of patients with BA; 40,5% (145/358) of children with BA had multimorbidity of the nasal pathology - a combination of three or more nosological units. Conclusion: for children with atopic BA and nasal symptoms often have combined and multimorbid forms of URT pathology. Verification of nasal obstruction causes allows to individualize therapy for patients with BA and minimize negative impact of URT pathology on BA course.ΠΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ° (ΠΠ) ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΌ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ ΠΈ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π° Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ Π²Π΅ΡΡ
Π½ΠΈΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ (ΠΠΠ). Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ Π°ΠΊΡΠ΅Π½ΡΠΈΡΡΠ΅ΡΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΠΌΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠΏΠ΅ΠΊΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΈΠ·ΡΡΠΈΡΡ ΡΡΡΡΠΊΡΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΠ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 358 Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΠ, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ Π΄Π΅ΡΠ΅ΠΉ ΡΠΎΡΡΠ°Π²ΠΈΠ» 9,91 (9,47; 10,35) Π»Π΅Ρ, ΠΈΠ· Π½ΠΈΡ
ΠΌΠ°Π»ΡΡΠΈΠΊΠΎΠ² 67,9% (192/358), Π° ΡΠ°ΠΊΠΆΠ΅ 108 Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΆΠ°Π»ΠΎΠ±Π°ΠΌΠΈ Π½Π° Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π½ΠΎΡΠΎΠ²ΠΎΠ³ΠΎ Π΄ΡΡ
Π°Π½ΠΈΡ, ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡΡ
ΠΏΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΡ ΠΈ ΠΏΠΎΠ»Ρ, Π½ΠΎ Π½Π΅ ΠΈΠΌΠ΅Π²ΡΠΈΡ
ΠΠ. ΠΠΎΠΌΠΈΠΌΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Π²ΠΈΠ΄Π΅ΠΎΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΡΡΠΈ Π½ΠΎΡΠ° ΠΈ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Ρ Π²ΡΠ΅Ρ
Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ Π±ΡΠ» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΈΡ (ΠΠ ) ΠΈ/ΠΈΠ»ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΈΡ (ΠΠ Π‘) Ρ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΡΠΈΡΡΠΈΡΡΡΡΠΈΡ
ΡΠΎΡΠΌ. Β«ΠΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅Β» ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΠ /ΠΠ Π‘ ΠΈΠΌΠ΅Π»ΠΎ ΠΌΠ΅ΡΡΠΎ Ρ 11,7% (42/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Ρ ΠΎΡΡΠ°Π»ΡΠ½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π½Π°Π·Π°Π»ΡΠ½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ Π±ΡΠ»ΠΈ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ΠΌ ΠΠ /ΠΠ Π‘ Ρ ΠΈΠ½ΡΠΌΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ. ΠΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡ Π³Π»ΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΌΠΈΠ½Π΄Π°Π»ΠΈΠ½Ρ ΠΈΠΌΠ΅Π»Π° ΠΌΠ΅ΡΡΠΎ Ρ 61,2% (219/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π³ΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΈΡ - Ρ 9,2% (33/358) Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ, Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π°ΡΡ
ΠΈΡΠ΅ΠΊΡΠΎΠ½ΠΈΠΊΠΈ Π½ΠΎΡΠ° Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ Ρ 50% (179/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ Π΄Π²ΡΡ
Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π½ΠΎΡΠ° ΠΈΠΌΠ΅Π»ΠΎ ΠΌΠ΅ΡΡΠΎ Ρ 47,8% (117/358) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ, Ρ 40,5% (145/358) Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠ Π±ΡΠ»Π° ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΠΌΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΡ Π½Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ - ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΡΡΠ΅Ρ
ΠΈ Π±ΠΎΠ»Π΅Π΅ Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΅Π΄ΠΈΠ½ΠΈΡ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: Π΄Π»Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΠ ΠΈ Π½Π°Π·Π°Π»ΡΠ½ΡΠΌΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Ρ ΡΠΎΡΠ΅ΡΠ°Π½Π½ΡΠ΅ ΠΈ ΠΌΡΠ»ΡΡΠΈΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ. ΠΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΡΠΈΡΠΈΠ½ Π½Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ ΠΈ Π½ΠΈΠ²Π΅Π»ΠΈΡΠΎΠ²Π°ΡΡ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΠ
Connection between body mass index, relative body mass index and bronchial patency indicators in children with bronchial asthma
Objective of the study: To study the relationship between nutritional status parameters and spirometric parameters reflecting bronchial patency in children with bronchial asthma (BA). Materials and methods of research: A retrospective non-randomized single-center comparative study of 417 children, 297 boys (71,2%) and 120 girls (28,8%), age 10,5 [10,2; 10,9] years with atopic BA. All children underwent spirometry and anthropometry. Results: An increase in body weight from underweight to obesity was accompanied by a decrease in the FEV1/FVC ratio from 80,4 [48,8; 97,9]% to 73,7 [47,4; 88,1]%, p=0,003, MEF 25% (% pred) from 70,9 [19,4; 171,5]% to 55,1 [20,2; 110,0]%, p=0,003 and FEF 25-75 (% pred) from 79,2 [28,6; 173,6]% to 65,9 [24,8; 103,5]%, p=0,02; at the same time, there is an increase in FVC% pred from 104,88Β±17,26 to 112,13Β±16,22%, Ρ=0,01, which may be associated with the phenomenon of dysanapsis. The body mass index (BMI) and relative BMI values negatively correlate with the FEV1/FVC index (r=-0,20 and r=-0,19, respectively, p=0,0001). Similar data for the general cohort was collected in the cohort of boys. Conclusion: Indicators of nutritional status, as well as spirometric indicators, can be important components of an objective assessment of the condition of children with asthma for individual effective therapy of the disease. Β© 2021, Pediatria Ltd.. All rights reserved
Regression Models of AcidβBase Properties of Peat Swamps as Operational Criteria for Their Chemical Classification
Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control
Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD. All patients had AR/ARS; in 76.3% (63/82) of children, UAP had a multimorbid character with the presence of NOD. Significant correlations were found between ACQ-5 and TNSS (R=0.40, p<0.0001) and ACQ-5 and SNOT-20 (R=0.42, p<0.0001). Correlations between TNSS/ACQ-5 and SNOT-20/ACQ-5 were higher in patients who do not have a combination of AR/ARS with NOD (R=0.67, p=0.0012; R=0.50, p=0.022, resp.) than in patients who have AR/ARS combined with NOD (R=0.30, p=0.015; R=0.26, p=0.04, resp.). Thus, the association of BA control level with the expression of nasal and synonasal symptoms is higher in children who do not have multimorbid UAP. Β© 2018 T. I. Eliseeva et al