Модификация пероксинитритом как способ улучшения цитосовместимости гидрогелей на основе альгината натрия

Sodium alginate is one of the most frequently used materials in biomedicine. However, alginate-based scaffolds have extremely low adhesive properties and have to be improved. The authors have proposed combined hydrogels of gelatin and sodium alginate which have been modified by peroxynitrite in heterophasic conditions using ethanol. It has been determined that thus modified sodium alginate contains an increased level of carbonyl, carboxyl and nitro groups. Authors have developed chemically and chemical-enzymatically cross-linked hydrogels with better adhesive properties and absence of cytotoxicity. Moreover, sodium alginate modification has a positive impact on cell morphology in comparison with control group of non-adhesive alginate-gelatin hydrogels. It allows the further improvement and application of the biomaterial which have been developed by the authors for bioengineering scaffold production and 3D culturing.Альгинат натрия – один из часто применяемых в биомедицине материалов. Однако скаффолды и гидрогели на его основе обладают крайне слабыми адгезивными свойствами и нуждаются в совершенствовании. Нами предложены комбинированные гидрогели на основе желатина и альгината натрия, модифицированного пероксинитритом в гетерофазных условиях в среде этилового спирта. Модифицированный таким образом альгинат натрия обладает увеличенным содержанием карбонильных, карбоксильных и нитрогрупп. Разработанные авторами ионно и ионно-ферментативно сшитые гидрогели обладают улучшенными адгезивными свойствами и не проявляют цитотоксичности. Кроме того, модификация альгината натрия оказывает положительное влияние на морфологию клеток по сравнению с контрольными неадгезивными альгинат-желатиновыми гидрогелями. Это делает возможным дальнейшее совершенствование и использование разработанного биоматериала для получения биоинженерных скаффолдов и 3D-культивирования

How to superize Liouville equation

So far, there are described in the literature two ways to superize the Liouville equation: for a scalar field (for $N\leq 4$) and for a vector-valued field (analogs of the Leznov--Saveliev equations) for N=1. Both superizations are performed with the help of Neveu--Schwarz superalgebra. We consider another version of these superLiouville equations based on the Ramond superalgebra, their explicit solutions are given by Ivanov--Krivonos' scheme. Open problems are offered

The preliminary study of diabetic retinopathy detection based on intensity parameters with optical coherence tomography angiography

In this study, the diagnostic abilities of intensity parameters of optical coherence tomography angiography (OCTA) images in the early detection of diabetic retinopathy (DR) were determined. 78 normal healthy eyes, 10 diabetic eyes with mild non-proliferative diabetic retinopathy (NPDR), and 10 diabetic eyes with moderate NPDR were employed. Four retinal vascular plexuses were generated by using OCTA, which included the nerve fiber layer vascular plexus (NFLVP), superficial vascular plexus (SVP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP). The parafoveal zone in each OCTA image was divided into four sectors which were the superior, temporal, inferior, and nasal sectors. Five intensity parameters including the mean, median, variance, skewness, and kurtosis of intensities were calculated for each sector. The factor of aging was evaluated among normal healthy subgroups. The diagnostic abilities of intensity parameters were evaluated between normal healthy subjects and diabetic patients with DR. Our results showed that the variance of intensities in superior sector in ICP achieved the highest AUROC value of 0.95 with the sensitivity of 0.87 and the specificity of 1.000 when comparing the diabetic patients with the mild NPDR to normal healthy subjects. The mean intensity in superior sector in ICP achieved the second highest AUROC value of 0.95 with the sensitivity of 0.90 and the specificity of 0.90 when comparing the diabetic patients with the moderate NPDR to normal healthy subjects. The proposed approach could offer a simple way to differentiate diabetic patients with early DR from normal healthy subjects without performing the relatively complicated image processing techniques.This study was supported by Zhejiang Provincial Natural Science Foundation (LY20H180009), Qianjiang Talent Plan (QJD1803009), Ningbo Science and Technology Service Industry Demonstration Project (2020F031), Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project (2023ZL647), and Ministry of Science and Higher Education of the Russian Federation as part of the Program for increasing the competitiveness of Samara University among the world's leading research and educational centers for 2013–2020

Radiative decays of light vector mesons

The new data on $\rho,\omega,\phi$ radiative decays into $\pi^0\gamma,\eta\gamma,\eta'\gamma$ from SND experiment at VEPP-2M $e^+e^-$ collider are presented.Comment: 5 pages, 2 figures, talk given at 8th International Conference on Hadron Spectroscopy (HADRON 99), Beijing, China, 24-28 Aug 199

New Data from SND Detector in Novosibirsk

The current status of experiments with SND detector at VEPP-2M e^+e^- collider in the energy range 2E_0=400-1400 MeV and recent results of data analysis for $\phi$, $\omega$ and $\rho$ decays and e^+e^- annihilation into hadrons are presented.Comment: 7 pages, 8 figures, Latex2e, uses espcrc1.sty. Talk given at 8th International Conference on Hadron Spectroscopy (HADRON 99), Beijing, China, 24-28 Aug 199

New experimental data for the decays ϕ→μ+μ−\phi\to\mu^+\mu^- and ϕ→π+π−\phi\to\pi^+\pi^- from SND detector

The processes $e^+e^-\to\mu^+\mu^-$ and $e^+e^-\to\pi^+\pi^-$ have been studied with SND detector at VEPP-2M $e^+e^-$ collider in the vicinity of $\phi(1020)$ resonance. The branching ratios $B(\phi\to\mu^+\mu^-)=(3.30\pm 0.45\pm 0.32)\times 10^{-4}$ and $B(\phi\to\pi^+\pi^-)=(0.71\pm 0.11\pm 0.09)\times 10^{-4}$ were obtained.Comment: 5 pages, 4 figures, talk given at 8th International Conference on Hadron Spectroscopy (HADRON 99), Beijing, China, 24-28 Aug 199