MObile Technology for Improved Family Planning: update to randomised controlled trial protocol.

BACKGROUND: This update outlines changes to the MObile Technology for Improved Family Planning study statistical analysis plan and plans for long-term follow-up. These changes result from obtaining additional funding and the decision to restrict the primary analysis to participants with available follow-up data. The changes were agreed prior to finalising the statistical analysis plan and sealing the dataset. METHODS/DESIGN: The primary analysis will now be restricted to subjects with data on the primary outcome at 4-month follow-up. The extreme-case scenario, where all those lost to follow-up are counted as non-adherent, will be used in a sensitivity analysis. In addition to the secondary outcomes outlined in the protocol, we will assess the effect of the intervention on long-acting contraception (implant, intra-uterine device and permanent methods).To assess the long-term effect of the intervention, we plan to conduct additional 12-month follow-up by telephone self-report for all the primary and secondary outcomes used at 4 months. All participants provided informed consent for this additional follow-up when recruited to the trial. Outcome measures and analysis at 12 months will be similar to those at the 4-month follow-up. The primary outcomes of the trial will be the use of an effective modern contraceptive method at 4 months and at 12 months post-abortion. Secondary outcomes will include long-acting contraception use, self-reported pregnancy, repeat abortion and contraception use over the 12-month post-abortion period. DISCUSSION: Restricting the primary analysis to those with follow-up data is the standard approach for trial analysis and will facilitate comparison with other trials of interventions designed to increase contraception uptake or use. Undertaking 12-month trial follow-up will allow us to evaluate the long-term effect of the intervention. TRIAL REGISTRATION: ClinicalTrials.gov NCT01823861

Poisson noise induced switching in driven micromechanical resonators

We study Poisson-noise induced switching between coexisting vibrational states in driven nonlinear micromechanical resonators. In contrast to Gaussian noise induced switching, the measured logarithm of the switching rate is proportional not to the reciprocal noise intensity, but to its logarithm, for fixed pulse area. We also find that the switching rate logarithm varies as a square root of the distance to the bifurcation point, instead of the conventional scaling with exponent 3/2.Comment: accepted by PR

Activation barrier scaling and crossover for noise-induced switching in a micromechanical parametric oscillator

We explore fluctuation-induced switching in a parametrically-driven micromechanical torsional oscillator. The oscillator possesses one, two or three stable attractors depending on the modulation frequency. Noise induces transitions between the coexisting attractors. Near the bifurcation points, the activation barriers are found to have a power law dependence on frequency detuning with critical exponents that are in agreement with predicted universal scaling relationships. At large detuning, we observe a crossover to a different power law dependence with an exponent that is device specific.Comment: 5 pages, 5 figure

A Proton Magnetic Resonance Study of the Association of Lysozyme with Monosaccharide Inhibitors

It has been shown that the acetamido methyl protons of N-acetyl-d-glucosamine undergo a chemical shift to higher fields in their proton magnetic resonance spectrum when the inhibitor is bound to lysozyme. The observed chemical shift in the presence of the enzyme is different for the agr- and ß-anomeric forms of 2-acetamido-2-deoxy-d-glucopyranose indicating either a difference in the affinity of the anomeric forms for lysozyme or different magnetic environments for the methyl protons in their enzyme-bound state. That the agr- and ß-anomeric forms of GlcAc bind to lysozyme in a competitive fashion was indicated by observing the proton magnetic resonance spectra in the presence of 2-acetamido-d3-2-deoxy-agr-d-glucopyranose. The methyl glycosides, methyl-agr-GlcAc and methyl-ß-GlcAc, were also shown to bind competitively with both anomers of GlcAc. Quantitative analysis of the chemical shift data observed for the association of GlcAc with lysozyme was complicated by the mutarotation of GlcAc between its agr- and ß-anomeric forms. However, in the case of the methyl glucosides, where the conformation of each anomer is frozen, it was possible to analyze the chemical shift data in a straightforward manner, and the dissociation constant as well as the chemical shift of the acetamido methyl protons of the enzyme-inhibitor complex was determined for both anomers. The results indicate that the two anomers of methyl-GlcAc bind to lysozyme with slightly different affinities but that the acetamido methyl groups of both anomers experience identical magnetic environments in the enzyme-inhibitor complex

Pairing mechanism in Fe pnictide superconductors

By applying an exact unitary transformation to a two-band hamiltonian which also includes the effects due to large pnictogen polarizabilities, we show that an attractive spin-mediated Hubbard term appears in the $d_{xz}$, $d_{yz}$ nearest-neighbour channel. This pairing mechanism implies a singlet superconducting order parameter in iron pnictides.Comment: 4 pages, 3 figure

Gravastars and Black Holes of Anisotropic Dark Energy

Dynamical models of prototype gravastars made of anisotropic dark energy are constructed, in which an infinitely thin spherical shell of a perfect fluid with the equation of state $p = (1-\gamma)\sigma$ divides the whole spacetime into two regions, the internal region filled with a dark energy fluid, and the external Schwarzschild region. The models represent "bounded excursion" stable gravastars, where the thin shell is oscillating between two finite radii, while in other cases they collapse until the formation of black holes. Here we show, for the first time in the literature, a model of gravastar and formation of black hole with both interior and thin shell constituted exclusively of dark energy. Besides, the sign of the parameter of anisotropy ($p_t - p_r$) seems to be relevant to the gravastar formation. The formation is favored when the tangential pressure is greater than the radial pressure, at least in the neighborhood of the isotropic case ($\omega=-1$).Comment: 16 pages, 8 figures. Accepted for publication in Gen. Rel. Gra

Q-band electron nuclear double resonance (ENDOR) and X-band EPR of the sulfobetaine 12 heat-treated cytochrome c oxidase complex

Heat treatment of the bovine cytochrome c oxidase complex in the zwitterionic detergent sulfobetaine 12 (SB-12) results in loss of subunit III and the appearance of a type II copper center as characterized by electron paramagnetic resonance (EPR) spectroscopy. Previous authors (Nilsson, T., Copeland, R. A., Smith, P. A., and Chan, S. I. (1988) Biochemistry 27, 8254-8260) have interpreted this type II copper center as a modified version of the CuA site. By using electron nuclear double resonance spectroscopy, it is found that the CuA proton and nitrogen resonances remain present in the SB-12 heat-treated enzyme and that three new nitrogen resonances appear having hyperfine coupling constants consistent with histidine ligation. These hyperfine coupling constants correlate well with those recently found for the CuB histidines from the cytochrome aa3-600 quinol oxidase from Bacillus subtilis (Fann, Y. C., Ahmed, I., Blackburn, N. J., Boswell, J. S., Verkhovskaya, M. L., Hoffman, B. M., and Wikström, M. (1995) Biochemistry 34, 10245-10255). In addition, the total EPR-detectable copper concentration per enzyme molecule approximately doubles upon SB-12 heat treatment. Finally, the observed type II copper EPR spectrum is virtually indistinguishable from the EPR spectrum of CuB of the as-isolated cytochrome bo3 complex from Escherichia coli. These data indicate that the type II copper species that appears results from a breaking of the strong antiferromagnetic coupling of the heme a3-CuB binuclear center

More is Less: Perfectly Secure Oblivious Algorithms in the Multi-Server Setting

The problem of Oblivious RAM (ORAM) has traditionally been studied in a single-server setting, but more recently the multi-server setting has also been considered. Yet it is still unclear whether the multi-server setting has any inherent advantages, e.g., whether the multi-server setting can be used to achieve stronger security goals or provably better efficiency than is possible in the single-server case. In this work, we construct a perfectly secure 3-server ORAM scheme that outperforms the best known single-server scheme by a logarithmic factor. In the process, we also show, for the first time, that there exist specific algorithms for which multiple servers can overcome known lower bounds in the single-server setting.Comment: 36 pages, Accepted in Asiacrypt 201

Measurables of CPCP Violation in Bd→DCP0KSB_d\to D^0_{CP}K_S at a BB-meson Factory

In the context of the standard electroweak model, we emphasize that $B_d\rightarrow D^0_{CP}K_S$ ($D^0_{CP}$ denotes a $CP$ eigenstate of $D^0$ or $\bar{D}^0$) can compete with $B_d\rightarrow \pi^+\pi^-$ in studying $CP$ violation and probing the Cabibbo-Kobayashi-Maskawa unitarity triangle. We discuss the measurables of direct and indirect $CP$ asymmetries in $B^0_d$ vs $\bar{B}^0_d\rightarrow D^0_{CP}K_S$ under the circumstance of an asymmetric $B$-meson factory running on the $\Upsilon(4S)$ resonance, and show that both the weak and strong phases are experimentally determinable even in the presence of unknown final-state interactions.Comment: 6 Postscript pages, accepted for publication in IL Nuovo Cimento A as a "Note Brevi

Supernarrow spectral peaks near a kinetic phase transition in a driven, nonlinear micromechanical oscillator

We measure the spectral densities of fluctuations of an underdamped nonlinear micromechanical oscillator. By applying a sufficiently large periodic excitation, two stable dynamical states are obtained within a particular range of driving frequency. White noise is injected into the excitation, allowing the system to overcome the activation barrier and switch between the two states. While the oscillator predominately resides in one of the two states for most excitation frequencies, a narrow range of frequencies exist where the occupations of the two states are approximately equal. At these frequencies, the oscillator undergoes a kinetic phase transition that resembles the phase transition of thermal equilibrium systems. We observe a supernarrow peak in the power spectral densities of fluctuations of the oscillator. This peak is centered at the excitation frequency and arises as a result of noise-induced transitions between the two dynamical states.Comment: 4 pages, 4 figure