Domain-mediated interactions for protein subfamily identification

Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu

International linkage of real interest rates: the case of East Asian countries

This paper examines linkage of real interest rates for a group of selected countries in East Asia. The countries under study include Japan, Korea, Singapore, Malaysia and Thailand. The long run relationship is tested and estimated using the conitegration analysis. We also have conducted the impulse response analysis based on unrestricted vector autoregression, using the bias-corrected wild bootstrap for statistical inference. Our results show that (1) there exists a long run equilibrium relationship, (2) there are interesting short run dynamic interactions, in which Singapore, Malaysia and Thailand play the role of equilibrating factorFinancial linkage; Real interest rate parity; Cointegration analysis; Wild bootstrap

Production of the pentaquark Θ+\Theta^+ in npnp scattering

We study $np\to \Lambda\Theta^{+}$ and $np\to \Sigma^{0}\Theta^{+}$ processes for both of the positive and negative parities of the $\Theta^{+}$. Employing the effective chiral Lagrangians for the $KNY$ and $K^*NY$ interactions, we calculate differential cross sections as well as total cross sections for the $np\to \Sigma^0 \Theta^+$ and $np\to \Lambda\Theta^+$ reactions. The total cross sections for the positive-parity $\Theta^+$ turn out to be approximately ten times larger than those for the negative parity $\Theta^+$ in the range of the CM energy $\sqrt{s}_{\rm th}\le \sqrt{s}\le 3.5 {\rm GeV}$. The results are rather sensitive to the mechanism of $K$ exchanges in the $t$ -- channel.Comment: 9 pages and 11 figure

Inclusive angular distribution of alpha and Li fragments produced in the Fe-C and Fe-Pb collisions at 1.88 GeV/u

The LS (laboratory system) emission angles theta for 2188 and 298 Li fragments, produced inclusively in relativistic Fe-C and Fe-Pb collisions, have been measured in reference to incident Fe-ion beam tracks nearby in nuclear emulsion. An empirical differential frequency formula, dN(cot theta) = exp (a + b cot theta)d(cot theta) is obtained with the constant b approx. = -0.026 at 1.88 GeV/u, which seems to be independent on the kinds of target nucleus as well as on the kinds of projectile fragments