Influence of the inert and active ion bombardment on structure of the transition metal thin films

The results of the experimental research of the inert (He, Ne, Ar, Kr, Xe) and active (O, N) ion impact on the transition metal structure are presentedyesBelgorod State Universit

ASSESSMENT OF THE ECONOMIC POTENTIAL OF THE ENTERPRISE

Purpose of the study: The article deals with the problems of forming and increasing the efficiency of using the basic production assets of an enterprise. Methodology: Methods of working with physically challenged children (PCC) are described in the works by V .V.Linkov, N .N. Malofeev, N. M. Nazarov, etc. They consider various methods and techniques of organizing educational work with children having health problems. Results: The analysis of the effectiveness of the formation and use of the basic production assets of a machine-building enterprise has been carried out, and measures have been considered to improve their formation and use. Applications of this study: This research can be used for the universities, teachers, and students. Novelty/Originality of this study: In this research, the model of assessment of the economic potential of the enterprise is presented in a comprehensive and complete manner

Crystal and molecular structure of two insecticides: Amido-o, s-dimethylthiophosphate and n-acetamido- o, s-dimeth ylthiophosphate

The crystal and molecular structure of title compounds have been determined by means of X-ray analysis. The amido-O.S-dimethylthiophosphate (1) crystallizes in the monoclinic space group P21/n with cell dimensions a = 5. 374(3), b = 9. 220(4), c = 13.847(5) Å and β = 101.08(5)° at the - 100°C. The N-acetamido-O.S-dimethylthiophosphate (2) crystallizes in the monoclinic space group P21/c with cell dimensions a = 11. 547(3), b = 8. 545(2), c = 8.954(5) Å and β = 93.03(4)°. The structures were solved by direct methods and refined by least-squares to R = 0. 0493(1) and 0.0482(2). The coordination around P of the molecules (1) and (2) is distorted tetrahedrally. Molecules have nearly planar moieties HCSP=O and HNPOC (1), HCSP=O and HCC (0) NHPOC (2) with trans-orientation HCSP, CSP=O and NPOC groups. The angle between these planes is 85.3° (1) and 90.3° (2). There are intermolecular P=O … H-N hydrogen bonds in the crystal structures (1) and (2). © 1991 Taylor & Francis Group, LLC. All rights reserved

Thymosin β4 as basis for creation of a reparation preparation of new generation

On the basis of its multipurpose activities during regeneration of fabrics in various experiments on animals, Thymosin β4 has the potential for new researches, in kidneys and a liver, and also recovery of a spinal cord, bones and injury of ligaments. Besides, it can be useful in case of treatment of a wide range of other diseases, including concerning consequences of old bacterial damages and viral infection

New opportunities in the treatment of asthenic symptoms after a new coronavirus infection

Introduction. Asthenia is an urgent problem during the pandemic of new coronavirus infection (COVID-19) because of its high frequency regardless of the severity of the disease.The purpose of this subanalysis of data from the multicenter controlled randomized clinical trial TONUS was to evaluate the efficacy and safety of meldonium therapy for аsthenia in COVID-19 survivors.Materials and methods. A total of 880 patients with asthenia who underwent COVID-19 within the last 6 months were included in the analysis. The efficacy of asthenia therapy was assessed by the MFI-20 scale, Schulte tables, and the General Clinical Impression (CGI) scale. All patients were previously randomized in two parallel branches of the TONUS study, including patients without concomitant disease in TONUS-1 (who received meldonium 500 mg/day for 14 days in the main group) and patients with cardiovascular or cerebrovascular disease in TONUS-2, who received meldonium at a dose of 1000 mg/day for 42 days in the main group. In both arms of the study, the drugs in the comparison groups were multivitamin complexes.Results. For the TONUS-1 groups.In the group of patients receiving meldonium compared with the control group (p < 0.001): total MFI-20 score decreased and was 31 (25; 40); MFI-20 –35 (–46; 23); performance value –5 (–11; –2) seconds; proportion of patients with significant improvement (by CGI-I) by the end of follow-up was 92.8%. For TONUS-2 groups.In the group of patients receiving meldonium compared with the control group (p < 0.001): total MFI-20 score decreased to 35 (27; 44); MFI-20 –34 (–46; –21), performance value –5 (–11; –2), proportion of patients with significant improvement (by CGI-I) by end of follow-up – 90.8%.Conclusion. Significant positive dynamics and regression of asthenia were noted in the groups of patients receiving meldonium in comparison with the control groups

Effect of triphosphate modifications in 2′-deoxynucleoside 5′-triphosphates on their specificity towards various DNA polymerases

AbstractSome natural and glycon-modified dNTPs with β,γ-pyrophosphate substitution at the triphosphate residue were synthesized and studied to evaluate the effect of these modifications on substrate properties of dNTPs in DNA synthesis catalyzed by human placental DNA polymerases α and β, avian myeloblastosis virus reverse transcriptase, and calf thymus terminal deoxynucleotidyl transferase. Reverse transcriptase proved to be the enzyme least specific to such modifications; the substrate activity of β,γ-methylenediphosphonate substituted dTTP and 3′-azido-3′-deoxy-dTTP decreased in the following order: CF2=CHF>CBr2>CFMe≫CH2. This order is individual for each DNA polymerase. It is interesting to mention that β,γ-CBr2 substituted dTTP is neither a substrate nor an inhibitor of DNA polymerase β. This specificity distinguishes DNA polymerase β from other DNA polymerases studied

The role of digital consciousness in change management

The article deals with the problems of change management in the new conditions of superfragility of the BANI-world. Interpretations of the concepts of “transcendental thinking”, “digital consciousness”, “immersiveness” are given. The prerequisites substantiating the idea that transcendental thinking needs to be cultivated in the organisation in order to achieve effective management flexibility are presented. The latter is formed in the broader context of the digital consciousness organisational culture, without which it is impossible to set up the organisation’s staff for a positive perception of immersive management practices and the digital technologies productive use. Barriers to the transformation of organisational processes have been identified. It has been shown that the digital transformation of the organisation increases the resistance on the part of the staff by digital resistance plane, when aversion to any change correlates with a lack of ­understanding of digital opportunities. The relationship between the conceptual methodologies of digital consciousness and metacognition and the effectiveness of the formation of a change management strategy has been established