66 research outputs found

    COMPUTER ANALYSIS OF THE UNDERLYING EQUILIBRIUM MODELS WITH PUBLIC GOOD

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    This article discusses an option of the mathematical model of economic situations with public goods consumed by several market participants simultaneously. Computer analysis of this model was performed by using the MATHCAD package which allows toillustrate some techniques of determining of market balance. It was assumed that the participants, considering the choice of the other is equal to their previous decision, comes to the agreed result in finish

    Risk factors for anemia in newborns

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    The objective was to assess clinical and anamnestic indicators and characteristics of blood erythrocytes in newborns according to the severity of anemia. Materials and methods: we examined the 65 case records of newborns with anemia who received medical treatment in pathology department of Rostov Research Institute of Obstetrics and Pediatrics from November, 2015 to March, 2016. All newborns were divided into 3 groups depending on the severity of anemia: I group included 40 newborns with mild case of anemia, II group – 8 infants with medium-heavy anemia, III group – 17 newborns with heavy extent of disease. Results. The most common risk factors of severe anemia on the distaff side are obesity (35.3%), anemia (100%), threatened miscarriage (65,%), cytomegalovirus infection (41%), gestational diabetes (or 41.2%). Conclusion: The risk factors of anemia in newborns are unfavorable for the antenatal period complicated by anemia, threatened miscarriage, gestational diabetes mellitus, cytomegalovirus infection, presence of respiratory distress syndrome, cerebral ischemia II degree in combination with hemolytic disease of the newborn

    Climate changes in East Siberia (Russia) in the Holocene based on diatom, chironomid and pollen records from the sediments of Lake Kotokel

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    We analysed a 620-cm-long sediment record from Lake Kotokel located in East Siberia (Russia) for subfossil diatoms, chironomids and pollen to provide a reconstruction of the climate history of the area for the last 12. 2 kyr. The subfossil records show differing time lags in their responses to climate change; diatoms and chironomids were more sensitive to climate change than the pollen record. Changes in the biogenic proxies seem related with changes in insolation, the temperature of the North Atlantic and solar activity. The chironomids Chironomus plumosus-type and Einfeldia carbonaria-type and the diatom Aulacoseira granulata were interpreted as markers of warm climate condition. The proxy records were divided into four periods (A, B, C and D) suggesting differing climate in East Siberia during the Holocene. Period D (12. 2-9. 5 kyr BP) at the beginning of the Holocene, according to chironomid and diatom records, was characterized by warm climate with summer temperatures close to modern. However, forest vegetation had not become fully established yet. During Period C (9. 5-5. 8 kyr BP), the climate seemed to gradually become colder and wetter from the beginning of Period C to 7 kyr BP. From 7 to 5. 8 kyr BP, the climate seemed to remain cold, but aridity increased. Period B (5. 8-1. 7 kyr BP) was characterised by frequent and sharp alternations between warm and cold conditions. Unstable conditions during this time are also registered in records from Lakes Baikal, Khubsugul and various other shallow lakes of the region. Optimal warm and wet conditions seemed to occur ca. 4 kyr BP. During Period A (the last 1. 5 kyr) the diatom and chironomid records show evidence of cold conditions at 1. 5-1 kyr BP, but the forest vegetation did not change significantly. Β© 2012 Springer Science+Business Media B.V

    A case of hyperplasia of the adrenal cortex in the newborn child

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    Clinical observation of a hyperplasia of the adrenal cortex in the newborn is presented. Main feature of this observation is the complicated course of this disease in the newborn against hypoxemic defeat of the central nervous system and neonatal jaundice. Now treatment of this congenital disease has to begin with the first week of life and includes complete hormonal and infusion therapy. In this observation child’s clinical improvement is noted

    Radiomics in the Diagnosis of Thyroid Nodules

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    The thyroid nodules (TNs) are widespread throughout the world: according to the pathological studies, they can be found in 50–60% of adults. Currently, ultrasound, computed tomography, magnetic resonance imaging and radionuclide diagnostics, such as positron emission tomography with computed tomography, are usually used to diagnose TNs in clinic. These techniques are mainly used to diagnose the nodile benignity and malignancy, the degree of invasion into adjacent tissues and metastases to lymph nodes. Thanks to the development of artificial intelligence, machine learning and the improvement of medical imaging equipment, radiomics has become a popular area of research in recent years. It allowes to obtain various quantitative characteristics from medical images, highlighting invisible features and significantly expanding the possibilities of identifying and predicting. Radiomics has a high potential in detecting and predicting TNs. We present the information on the development and workflow of radiomics. The article summarizes the application of various imaging techniques to identify benign and malignant TNs, determine invasiveness and metastases to lymph nodes, as well as some new advances in the field of molecular level and deep learning. The disadvantages of radiomics method are also given as well as prospects for its further development

    ΠŸΡ€ΠΎ Π·Π°Ρ…Π²ΠΎΡ€ΡŽΠ²Π°Π½Ρ–ΡΡ‚ΡŒ Π½Π° злоякісні новоутворСння Ρ‰Π΅Π»Π΅ΠΏΠ½ΠΎ-Π»ΠΈΡ†Π΅Π²ΠΎΡ— ділянки насСлСння ΠŸΠΎΠ»Ρ‚Π°Π²ΡΡŒΠΊΠΎΡ— області

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    ΠžΡ€Π³Π°Π½Ρ–Π·Π°Ρ†Ρ–Ρ якісної ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎΡ— Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΈ Ρ‚Π° ΠΏΡ€ΠΎΡ„Ρ–Π»Π°ΠΊΡ‚ΠΈΠΊΠ° злоякісних Π½ΠΎΠ²ΠΎΡƒΡ‚Π²ΠΎΡ€Π΅Π½ΡŒ Π½Π° ΡΡŒΠΎΠ³ΠΎΠ΄Π½Ρ– Π·Π°Π»ΠΈΡˆΠ°ΡŽΡ‚ΡŒΡΡ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΠΌΠΈ Π² Π΄Π΅Ρ€ΠΆΠ°Π²Ρ–. Ця Π³Ρ€ΡƒΠΏΠ° Π·Π°Ρ…Π²ΠΎΡ€ΡŽΠ²Π°Π½ΡŒ Π²ΠΏΡ€ΠΎΠ΄ΠΎΠ²ΠΆ останніх Ρ€ΠΎΠΊΡ–Π² стійко Π·Π°ΠΉΠΌΠ°Ρ” Π΄Ρ€ΡƒΠ³Π΅ місцС Π² структурі смСртності насСлСння, насампСрСд ΠΏΡ€Π°Ρ†Π΅Π·Π΄Π°Ρ‚Π½ΠΎΠ³ΠΎ Π²Ρ–ΠΊΡƒ, ΠΏΠΎΡΡ‚ΡƒΠΏΠ°ΡŽΡ‡ΠΈΡΡŒ Ρ‚Ρ–Π»ΡŒΠΊΠΈ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³Ρ–Ρ— сСрцСво-судинної систСми.; ΠžΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΡ качСствСнной онкологичСской ΠΏΠΎΠΌΠΎΡ‰ΠΈ ΠΈ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠ° злокачСствСнных Π½ΠΎΠ²ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π½Π° сСгодня ΠΎΡΡ‚Π°ΡŽΡ‚ΡΡ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π² государствС. Π­Ρ‚Π° Π³Ρ€ΡƒΠΏΠΏΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π½Π° протяТСнии послСдних Π»Π΅Ρ‚ устойчиво Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ‚ Π²Ρ‚ΠΎΡ€ΠΎΠ΅ мСсто Π² структурС смСртности насСлСния, ΠΏΡ€Π΅ΠΆΠ΄Π΅ всСго трудоспособного возраста, уступая Ρ‚ΠΎΠ»ΡŒΠΊΠΎ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ сСрдСчно-сосудистой систСмы.; The organization of high-quality oncological care and prevention of malignant neoplasms remains relevant in the country today. This group of diseases in recent years has consistently taken second place in the structure of mortality, especially working age, yielding only pathology of the cardiovascular system

    Π˜ΠΌΠΌΡƒΠ½ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½ G4-ассоциированноС Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ Π»Π΅Π³ΠΊΠΈΡ… Ρƒ подростка

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    Immunoglobulin G4-related disease is a recently recognized systemic immune-mediated condition characterized by lymphoplasmacytic infiltrate in various organs with IgG4 positive plasma cells. Isolated lung involvement is rare, difficult to diagnose and can mimic primary lung malignancy on imaging. We report the case of an isolated IgG4-related interstitial lung disease in a 16-year-old asymptomatic male adolescent with incidentally found bilateral nodular lesions by chest radiograph. The patient underwent surgical interventions for assumption of malignancy. Serum IgG4 levels was normal. Нistological examination revealed significant lymphoplasmacytic infiltrate with lymphoid follicle formation, peribronchial fibrosis, vascular obliteration. Prominent interstitial IgG4 positive plasma cell infiltrate was identified by immunohistochemistry. Isolated IgG4-related lung disease should be taken into account as a possible differential diagnosis of mass-forming lesions, even when no other organ manifestation is clinically apparent at the time of diagnosis.Π’Ρ‹Π΄Π΅Π»Π΅Π½Π½Ρ‹Π΅ Π½Π΅Π΄Π°Π²Π½ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½ (Ig) G4-ассоциированныС заболСвания (IgG4-АЗ) ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΡŽΡ‚ собой иммунозависимоС состояниС, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ характСризуСтся ΠΈΠ½Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΠ΅ΠΉ ΠΏΠΎΡ€Π°ΠΆΠ΅Π½Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½ΠΎΠ² IgG4 ΠΏΠΎΠ·ΠΈΡ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ плазматичСскими ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ. Π˜Π·ΠΎΠ»ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ΅ Π²ΠΎΠ²Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π»Π΅Π³ΠΊΠΈΡ… Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ Ρ€Π΅Π΄ΠΊΠΎ, ΠΏΡ€ΠΈ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΎΠ½ΠΎ ΠΌΠΎΠΆΠ΅Ρ‚ ΠΈΠΌΠΈΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ злокачСствСнноС Π½ΠΎΠ²ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ прСдставляСт Π½Π΅ΠΌΠ°Π»Ρ‹Π΅ трудности ΠΏΡ€ΠΈ диагностикС. Π’ ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΌ клиничСском наблюдСнии продСмонстрирован случай ΠΈΠ·ΠΎΠ»ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ IgG4-АЗ Π»Π΅Π³ΠΊΠΈΡ… Ρƒ 16-Π»Π΅Ρ‚Π½Π΅Π³ΠΎ подростка со случайно ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π½Ρ‹ΠΌΠΈ двусторонними ΡƒΠ·Π»ΠΎΠ²Ρ‹ΠΌΠΈ измСнСниями Π½Π° Ρ€Π΅Π½Ρ‚Π³Π΅Π½ΠΎΠ³Ρ€Π°ΠΌΠΌΠ΅ ΠΎΡ€Π³Π°Π½ΠΎΠ² Π³Ρ€ΡƒΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ ΠΏΡ€ΠΈ отсутствии симптомов. Π’ связи с ΠΏΠΎΠ΄ΠΎΠ·Ρ€Π΅Π½ΠΈΠ΅ΠΌ Π½Π° Π·Π»ΠΎΠΊΠ°Ρ‡Π΅ΡΡ‚Π²Π΅Π½Π½ΡƒΡŽ ΠΏΡ€ΠΈΡ€ΠΎΠ΄Ρƒ выявлСнных ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Ρ‹ хирургичСскиС Π²ΠΌΠ΅ΡˆΠ°Ρ‚Π΅Π»ΡŒΡΡ‚Π²Π°, ΠΏΡ€ΠΈ этом ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ IgG4 Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ Π±Ρ‹Π» Π² ΠΏΡ€Π΅Π΄Π΅Π»Π°Ρ… Π½ΠΎΡ€ΠΌΡ‹. ГистологичСски выявлСна Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Π°Ρ лимфоплазмоцитарная ΠΈΠ½Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΡ с ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Ρ… Ρ„ΠΎΠ»Π»ΠΈΠΊΡƒΠ»ΠΎΠ², ΠΏΠ΅Ρ€ΠΈΠ±Ρ€ΠΎΠ½Ρ…ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΉ Ρ„ΠΈΠ±Ρ€ΠΎΠ·, облитСрация сосудов. По Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ иммуногистохимичСского исслСдования ΠΏΠΎΠΊΠ°Π·Π°Π½Π° ΠΈΠ½Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΡ интСрстиция IgG4-ΠΏΠΎΠ·ΠΈΡ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ плазматичСскими ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ. На основании ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ клиничСского наблюдСния сдСлан Π²Ρ‹Π²ΠΎΠ΄, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈ Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ диагностикС ΠΈ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΈΠΈ нодулярных ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ‚ постановки Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΈΠ·ΠΎΠ»ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ΅ IgG4-АЗ Π»Π΅Π³ΠΊΠΈΡ… Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°Ρ‚ΡŒ Π΄Π°ΠΆΠ΅ ΠΏΡ€ΠΈ отсутствии клиничСских симптомов со стороны Π΄Ρ€ΡƒΠ³ΠΈΡ… ΠΎΡ€Π³Π°Π½ΠΎΠ²

    Π—Π°Ρ…Π²ΠΎΡ€ΡŽΠ²Π°Π½Ρ–ΡΡ‚ΡŒ Π½Π° ΠΏΠ΅Ρ€Π΅Π΄Π°ΠΊΠΎΠ²Ρ– стани слизової ΠΎΠ±ΠΎΠ»ΠΎΠ½ΠΊΠΈ ΠΏΠΎΡ€ΠΎΠΆΠ½ΠΈΠ½ΠΈ Ρ€ΠΎΡ‚Π° Π² ΠŸΠΎΠ»Ρ‚Π°Π²ΡΡŒΠΊΡ–ΠΉ області Π·Π° 2003-2009 Ρ€Ρ€.

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    Злоякісні новоутворСння Ρ” ΠΎΠ΄Π½Ρ–Ρ”ΡŽ Π· Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΡ… ΠΌΠ΅Π΄ΠΈΠΊΠΎ-Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΈΡ… Ρ‚Π° ΡΠΎΡ†Ρ–Π°Π»ΡŒΠ½ΠΎ-Π΅ΠΊΠΎΠ½ΠΎΠΌΡ–Ρ‡Π½ΠΈΡ… ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ Π² Π£ΠΊΡ€Π°Ρ—Π½Ρ–. УраТСння насСлСння Ρ†Ρ–Ρ”ΡŽ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³Ρ–Ρ”ΡŽ зростає, ΡΠΌΠ΅Ρ€Ρ‚Π½Ρ–ΡΡ‚ΡŒ Π½Π΅ ΠΌΠ°Ρ” Ρ‚Π΅Π½Π΄Π΅Π½Ρ†Ρ–Ρ— Π΄ΠΎ змСншСння [2,9]. ΠŸΡ–Π΄Π²ΠΈΡ‰Π΅Π½Π½Ρ ΠΊΠ°Π½Ρ†Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ навантаТСння Π½Π° насСлСння Π£ΠΊΡ€Π°Ρ—Π½ΠΈ ΠΎΠ±ΡƒΠΌΠΎΠ²Π»Π΅Π½Π΅ високим Ρ€Ρ–Π²Π½Π΅ΠΌ Π°Π½Ρ‚Ρ€ΠΎΠΏΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ забруднСння довкілля, Π·ΠΌΡ–Π½Π°ΠΌΠΈ способу Тиття насСлСння (куріння, зловТивання алкоголю, ΡΠ΅ΠΊΡΡƒΠ°Π»ΡŒΠ½Π° Ρ‚Π° Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈΠ²Π½Π° ΠΏΠΎΠ²Π΅Π΄Ρ–Π½ΠΊΠ° Ρ‚Π° Ρ–Π½..), сприяє Π·Π±Ρ–Π»ΡŒΡˆΠ΅Π½Π½ΡŽ кумулятивного Ρ€ΠΈΠ·ΠΈΠΊΡƒ Π·Π°Ρ…Π²ΠΎΡ€Ρ–Ρ‚ΠΈ Π½Π° Ρ€Π°ΠΊ; ЗлокачСствСнныС новообразования ΡΠ²Π»ΡΡŽΡ‚ΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π΄ΠΈΠΊΠΎ-биологичСских ΠΈ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-экономичСских ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ Π² Π£ΠΊΡ€Π°ΠΈΠ½Π΅. ΠŸΠΎΡ€Π°ΠΆΠ΅Π½ΠΈΠ΅ насСлСния этой ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ возрастаСт, ΡΠΌΠ΅Ρ€Ρ‚Π½ΠΎΡΡ‚ΡŒ Π½Π΅ ΠΈΠΌΠ΅Π΅Ρ‚ Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΠΈ ΠΊ ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΡŽ [2,9]. ΠŸΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠ°Π½Ρ†Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π½Π°Π³Ρ€ΡƒΠ·ΠΊΠΈ Π½Π° насСлСниС Π£ΠΊΡ€Π°ΠΈΠ½Ρ‹ обусловлСно высоким ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Π°Π½Ρ‚Ρ€ΠΎΠΏΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ загрязнСния ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰Π΅ΠΉ срСды, измСнСния ΠΎΠ±Ρ€Π°Π·Π° ΠΆΠΈΠ·Π½ΠΈ насСлСния (ΠΊΡƒΡ€Π΅Π½ΠΈΠ΅, Π·Π»ΠΎΡƒΠΏΠΎΡ‚Ρ€Π΅Π±Π»Π΅Π½ΠΈΠ΅ алкоголя, ΡΠ΅ΠΊΡΡƒΠ°Π»ΡŒΠ½Π°Ρ ΠΈ Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈΠ²Π½ΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ Π΄Ρ€ ..), способствуСт ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΡŽ кумулятивного риска Π·Π°Π±ΠΎΠ»Π΅Ρ‚ΡŒ Ρ€Π°ΠΊΠΎΠΌ; Malignant neoplasms are one of the most urgent medical and biological and socio-economic problems in Ukraine. Affected by this pathology, the mortality rate does not tend to decrease [2,9]. Increasing the carcinogenic burden on the population of Ukraine is conditioned by a high level of anthropogenic pollution of the environment, changes in the lifestyle of the population (smoking, alcohol abuse, sexual and reproductive behavior, etc.), increases the cumulative risk of cancer

    ВяТСлый ΠΎΠ±Π»ΠΈΡ‚Π΅Ρ€ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΉ Π±Ρ€ΠΎΠ½Ρ…ΠΎΠ±Ρ€ΠΎΠ½Ρ…ΠΈΠΎΠ»ΠΈΡ‚, ассоциированный с синдромом БтивСнса–ДТонсона

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    Pulmonary complications in StevensΒ Johnson syndrome (SJS) or toxic epidermal Β ecrolysis (TEN) are rare and mostly manifest as bronchoΒ bron chiolitis obliterans with poor prognosis. Recently, there is no effective therapy for this condition in patients with SJS / TEN. We described a case of SJS with progressive hypercapnic respiratory failure in 4.5 year boy who died despite an intensive treatment. herefore, lung transplantation should be considered at the early stage of this disease.Π›Π΅Π³ΠΎΡ‡Π½Ρ‹Π΅ ослоТнСния ΠΏΡ€ΠΈ синдромС БтивСнса–ДТонсона (Π‘Π‘Π”) ΠΈΠ»ΠΈ токсичСском ΡΠΏΠΈΠ΄Π΅Ρ€ΠΌΠ°Π»ΡŒΠ½ΠΎΠΌ Π½Π΅ΠΊΡ€ΠΎΠ»ΠΈΠ·Π΅ (ВЭН) ΡΠ²Π»ΡΡŽΡ‚ΡΡ Ρ€Π΅Π΄ΠΊΠΎΡΡ‚ΡŒΡŽ, прСдставлСны Π² основном ΠΎΠ±Π»ΠΈΡ‚Π΅Ρ€ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌ Π±Ρ€ΠΎΠ½Ρ…ΠΈΡ‚ΠΎΠΌ ΠΈΠ»ΠΈ Π±Ρ€ΠΎΠ½Ρ…ΠΈΠΎΠ»ΠΈΡ‚ΠΎΠΌ; ΠΏΡ€ΠΎΠ³Π½ΠΎΠ· ΠΏΡ€ΠΈ ΠΈΡ… Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ нСблагоприятСн. Π’ настоящСС врСмя эффСктивной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ этих состояний ΠΏΡ€ΠΈ Π‘Π‘Π” / ВЭН Π½Π΅ сущСствуСт. ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½ случай развития Π‘Π‘Π” Ρƒ ΠΌΠ°Π»ΡŒΡ‡ΠΈΠΊΠ° 4,5 Π»Π΅Ρ‚. НСсмотря Π½Π° интСнсивноС Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΎΠ±Π»ΠΈΡ‚Π΅Ρ€ΠΈΡ€ΡƒΡŽΡ‰Π΅Π³ΠΎ Π±Ρ€ΠΎΠ½Ρ…ΠΈΠΎΠ»ΠΈΡ‚Π°, Ρ€Π΅Π±Π΅Π½ΠΎΠΊ ΠΏΠΎΠ³ΠΈΠ± вслСдствиС ΠΏΡ€ΠΎΠ³Ρ€Π΅ΡΡΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΉ гипСркапничСской Π΄Ρ‹Ρ…Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ нСдостаточности. Показано, Ρ‡Ρ‚ΠΎ вопрос ΠΎ Π»Π΅Π³ΠΎΡ‡Π½ΠΎΠΉ трансплантации Π΄ΠΎΠ»ΠΆΠ΅Π½ Π±Ρ‹Ρ‚ΡŒ рассмотрСн ΡƒΠΆΠ΅ Π½Π° Ρ€Π°Π½Π½Π΅ΠΉ стадии заболСвания
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