A triple helix model for the structure of chromatin fiber

AbstractA model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI

Diamonds, gold and crime displacement: Hatton Garden, and the evolution of organised crime in the UK

The 2015 Hatton Garden Heist was described as the ‘largest burglary in English legal history’. However, the global attention that this spectacular crime attracted to ‘The Garden’ tended to concentrate upon the value of the stolen goods and the vintage of the burglars. What has been ignored is how the burglary shone a spotlight into Hatton Garden itself, as an area with a unique ‘upperworld’ commercial profile and skills cluster that we identify as an incubator and facilitator for organised crime. The Garden is the UK’s foremost jewellery production and retail centre and this paper seeks to explore how Hatton Garden’s businesses integrated with a fluid criminal population to transition, through hosting lucrative (and bureaucratically complex) VAT gold frauds from 1980 to the early 1990s, to become a major base for sophisticated acquisitive criminal activities. Based on extensive interviews over a thirty year period, evidence from a personal research archive and public records, this paper details a cultural community with a unique criminal profile due to the particularities of its geographical location, ethnic composition, trading culture, skills base and international connections. The processes and structures that facilitate criminal markets are largely under-researched (Antonopoulos et al. 2015: 11), and this paper considers how elements of Hatton Garden’s ‘upperworld’ businesses integrated with project criminals, displaced by policing strategies, to effect this transition

DNA bending versus DNA end joining activity of HMGB1 protein is modulated in vitro by acetylation.

International audienc

Syntesis of silica xerogel

Syntesis of silica xerogel: Silica xerogel was prepared from sodium silicate by sol-gel process followed by ambient pressure drying. Sodium silicate was neutralized with citric acid to form silica gel. To prepare xerogel, first the pore water of the gel was exchanged by ethanol and then surface modification was done by aging alcogel in tetraethylorthosilicate (TEOS)/ethanol solution. Before drying, TEOS/ethanol solvent was exchanged with n-heptane. Capillary stress and shrinkages were greatly reduced due to the low surface tension of n-heptane. The prepared xerogel was a opaque and crack-free solid, with bulk density of 0.67 g.cm -3 , porosity of about 80%. The nature of surface modification and thermal stability of the aerogel was studied by FTIR and DSC/TG respectively