8 research outputs found
Efficiency of radiotherapy during local hyperthermia in the treatment of laryngeal and laryngopharyngeal cancer
Cancer of the larynx and laryngopharynx, which is accessible to visual and instrumental examination, remains the most relevant and complicated problem among head and neck malignances as before. Investigations show that the incidence of cancer at these sites in Russia in the last decade has risen from 4.5 to 9.67 %. This is a severe and poor prognostic form of cancer, which is characterized by its nonspecific early clinical manifestations, complex anatomic and topographic structure, and a high rate of regional metastases. The mainstay of treatment for head and neck cancer involves 3 components: surgery, chemotherapy, and radiotherapy (RT), which are performed alone or in combination. The most commonly used technique is combined, frequently crippling due to organ-removing operations. The clinical introduction of current radio modifiers, local and deep hyperthermia systems, is a promising approach to improving the results of treatment, to enhancing the radiation damage of RT, and to achieving the tumor regression sufficient for surgical intervention without augmenting the early and late toxicity inherent in chemoradiation treatment. The results of the performed study of 35 patients with T2β3N0β2M0 laryngeal and laryngopharyngeal cancer proved the high efficiency of local hyperthermia in treating malignancies in this region during both preoperative (grades IIIβ IV therapeutic pathomorphism) and radical beam RT
ΠΠΠΠΠΠΠΠΠΠΠΠΠ― ΠΠΠΠΠ ΠΠΠ’ΠΠΠ¬ΠΠΠΠ Π ΠΠΠ Π Π’ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ‘Π’Π
Background. Colorectal cancer is the third most common cancer worldwide. The tendency towards increased incidence of colorectal cancer in Tomsk region correlates with World and Russian tendencies. The purpose of the study was to analyze the incidence rate of colorectal cancer in Tomsk region. Material and methods. The study was based on cancer register data collected at the Cancer Research Institute and Regional Cancer Center (Tomsk) and covered the period 2005 ΠΏΠΎ 2015. Demographic data were obtained from local authorities and government statistics. Results. In Tomsk region, colorectal cancer is the second most common cancer. During the study period (2005β15), the incidence rate of colorectal cancer increased by 39.9 %. The highest incidence rates were observed in patients aged 55 years and older. The median age of patients diagnosed with colorectal cancer in 2015 was 56.3 years. The female and male median age showed a decreasing tendency. In 2015, the colorectal cancer incidence rate in both females and males was the highest among the territories included into the Siberian Federal Region, being 30.9 per 100,000. The rate then stabilized in females, but tended to increase in males. The cumulative risk of developing cancer among the population of Tomsk region had increased, being 7.9 in 2015 compared to 6.5 % in 2005. The cumulative risk of developing cancer was higher in males than in females (10.1 % versus 6.9 %). A specialized care to patients with colorectal cancer over a 10-year period has improved, however one-year mortality rate remains high. The study has shown that screening programs based on the detection of occult blood in the stool are not specific enough. Colonoscopy using high-resolution endoscopy and narrow beam imaging (NBI) are recommended to use as a screening method for the detection of precancerous diseases of the colon.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΠΉ ΡΠ°ΠΊ (ΠΠ Π ) ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΡΠ°ΠΌΡΡ
ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΡ
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ. Π Π ΠΎΡΡΠΈΠΈ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠΎΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΡΠΈ Π½Π΅ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅. ΠΠΊΡΡΠ°Π»ΡΠ½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΈ Π΄Π»Ρ Π’ΠΎΠΌΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ, Π²Ρ
ΠΎΠ΄ΡΡΠ΅ΠΉ Π² ΡΠΎΡΡΠ°Π² Π‘ΠΈΠ±ΠΈΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΡΡΠ³Π°. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΡΠΈΡΡΠ°ΡΠΈΡ ΠΏΠΎ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌΡ ΡΠ°ΠΊΡ Π² Π’ΠΎΠΌΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ, ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠΈΡΡ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ ΠΏΠΎ Π΅Π΅ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π»ΠΈΡΡ Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2005 ΠΏΠΎ 2015 Π³. Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΡΠΈΡΠΈΠ°Π»ΡΠ½ΠΎ-ΠΎΡΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄ΠΈΡΠΏΠ°Π½ΡΠ΅ΡΠ°, Π΄Π°Π½Π½ΡΡ
Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΠ°ΡΠΈΡΡΠΈΠΊΠΈ ΠΎ Π³ΠΎΠ΄ΠΎΠ²ΠΎΠΉ ΡΠΈΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Β«ΠΠΠΠΠ‘Π’ΠΠ’Β». ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ 170 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π΅ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π° Π²ΠΈΠ΄Π΅ΠΎΠΊΠΎΠ»ΠΎΠ½ΠΎΡΠΊΠΎΠΏΠΈΡ Π·Π° 2013β2016 Π³Π³. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΡΠΈΡΠ»ΠΎ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π² Π’ΠΎΠΌΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠ²Π΅Π»ΠΈΡΠΈΠ»ΠΎΡΡ Π½Π° 39,9 %. Π ΡΡΡΡΠΊΡΡΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΎΠ±Π»Π°ΡΡΠΈ (Π±Π΅Π· ΡΡΠ΅ΡΠ° ΡΠ°ΠΊΠ° ΠΊΠΎΠΆΠΈ) ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΠΉ ΡΠ°ΠΊ Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ Π²ΡΠΎΡΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΡΡΡΡ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΡΡΠ°ΡΡΠ΅ 55 Π»Π΅Ρ. Π‘ΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ
Π² 2015 Π³. ΡΠΎΡΡΠ°Π²ΠΈΠ» 56,3 Π³ΠΎΠ΄Π°. Π Π°Π·Π»ΠΈΡΠΈΠ΅ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΌΠ΅ΠΆΠ΄Ρ Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΠΌΠΈ ΠΌΡΠΆΡΠΈΠ½Π°ΠΌΠΈ ΠΈ ΠΆΠ΅Π½ΡΠΈΠ½Π°ΠΌΠΈ β 2,6 Π³ΠΎΠ΄Π°. Π Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ
ΠΊΠ°ΠΊ Ρ ΠΌΡΠΆΡΠΈΠ½, ΡΠ°ΠΊ ΠΈ Ρ ΠΆΠ΅Π½ΡΠΈΠ½. Π 2015 Π³. ΠΠ°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΡ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ (ΠΎΠ±Π° ΠΏΠΎΠ»Π° 30,9 Π½Π° 100 ΡΡΡ. Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ) Π±ΡΠ»Π° ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΡΠ°ΠΌΡΡ
Π²ΡΡΠΎΠΊΠΈΡ
ΡΡΠ΅Π΄ΠΈ Π°Π΄ΠΌΠΈΠ½ΠΈΡΡΡΠ°ΡΠΈΠ²Π½ΡΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΉ, Π²Ρ
ΠΎΠ΄ΡΡΠΈΡ
Π² ΡΠΎΡΡΠ°Π² Π‘ΠΈΠ±ΠΈΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΡΡΠ³Π°. Π ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π»ΡΡ Ρ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠ΅ΠΉ ΠΊ ΡΠΎΡΡΡ Ρ ΠΌΡΠΆΡΠΈΠ½ ΠΈ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ Ρ ΠΆΠ΅Π½ΡΠΈΠ½. ΠΡΠΌΡΠ»ΡΡΠΈΠ²Π½ΡΠΉ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ Π Ρ ΠΆΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ» 7,9 %, ΡΡΠΎΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠ²Π΅Π»ΠΈΡΠΈΠ»ΡΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ 2005 Π³. (6,5 %). Π£ ΠΌΡΠΆΡΠΈΠ½ (10,1 %) ΠΎΠ½ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ ΠΆΠ΅Π½ΡΠΈΠ½ (6,9 %). ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ Π±ΠΎΠ»ΡΠ½ΡΠΌ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π·Π° 10-Π»Π΅ΡΠ½ΠΈΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΠ»ΡΡΡΠΈΠ»ΠΈΡΡ. ΠΠΎ ΠΎΡΡΠ°Π»Π°ΡΡ Π½ΠΈΠ·ΠΊΠΎΠΉ Π²ΡΡΠ²Π»ΡΠ΅ΠΌΠΎΡΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π½Π° ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΌΠΎΡΡΠ°Ρ
, Π·Π°ΠΏΡΡΠ΅Π½Π½ΠΎΡΡΡ ΡΠ½ΠΈΠ·ΠΈΠ»Π°ΡΡ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ, Π²ΡΡΠΎΠΊΠ° ΠΎΠ΄Π½ΠΎΠ³ΠΎΠ΄ΠΈΡΠ½Π°Ρ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΡΡΡ, ΠΌΠ΅Π½Π΅Π΅ ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Ρ Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ
Π½Π°Ρ
ΠΎΠ΄ΡΡΡΡ Π½Π° ΡΡΠ΅ΡΠ΅ 5 Π»Π΅Ρ ΠΈ Π±ΠΎΠ»Π΅Π΅. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ΠΎΠ²ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΠΊΡΡΡΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Π² ΠΊΠ°Π»Π΅, Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½Ρ. ΠΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΊΠ°ΠΊ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³Π° Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΡΠ΅Π΄ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ ΠΊΠΎΠ»ΠΎΠ½ΠΎΡΠΊΠΎΠΏΠΈΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π²ΠΈΠ΄Π΅ΠΎΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΎΠ² Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ·ΠΊΠΎΡΠΏΠ΅ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΠΈ (NBI)
EPIDEMIOLOGY OF COLORECTAL CANCER IN TOMSK REGION
Background. Colorectal cancer is the third most common cancer worldwide. The tendency towards increased incidence of colorectal cancer in Tomsk region correlates with World and Russian tendencies. The purpose of the study was to analyze the incidence rate of colorectal cancer in Tomsk region. Material and methods. The study was based on cancer register data collected at the Cancer Research Institute and Regional Cancer Center (Tomsk) and covered the period 2005 ΠΏΠΎ 2015. Demographic data were obtained from local authorities and government statistics. Results. In Tomsk region, colorectal cancer is the second most common cancer. During the study period (2005β15), the incidence rate of colorectal cancer increased by 39.9 %. The highest incidence rates were observed in patients aged 55 years and older. The median age of patients diagnosed with colorectal cancer in 2015 was 56.3 years. The female and male median age showed a decreasing tendency. In 2015, the colorectal cancer incidence rate in both females and males was the highest among the territories included into the Siberian Federal Region, being 30.9 per 100,000. The rate then stabilized in females, but tended to increase in males. The cumulative risk of developing cancer among the population of Tomsk region had increased, being 7.9 in 2015 compared to 6.5 % in 2005. The cumulative risk of developing cancer was higher in males than in females (10.1 % versus 6.9 %). A specialized care to patients with colorectal cancer over a 10-year period has improved, however one-year mortality rate remains high. The study has shown that screening programs based on the detection of occult blood in the stool are not specific enough. Colonoscopy using high-resolution endoscopy and narrow beam imaging (NBI) are recommended to use as a screening method for the detection of precancerous diseases of the colon
MEDICAL CARE FOR BREAST CANCER PATIENTS IN THE AMUR REGION FOR THE PERIOD 1999β2014
The purpose of the study was to estimate the medical care for cancer patients in the Amur region from 1999 to 2014. Material and methods. The study was based on cancer register data collected at the Oncology Dispensary of Amur region and covered the period 1999 to 2014. Results. Breast cancer is the most common cancer in women of the Amur region, accounting for 20.8 % of all cancer cases. In 2013, the breast cancer incidence rate was 52.8 per 100,000. The incidence rate for breast cancer increased by 36.4 % from 2003 to 2013, the overall rise being 2.2 %. The mortality rate decreased from 20.3 % in 2003 to 17.3 % in 2014. Cancer care in rural areas of the Amur region is worse than in Blagoveshchensk, which is the regional administrative center. The one-year mortality rate in rural areas is 1.3 times higher than that in the city. The one-year mortality rate is 1.3 times higher in rural areas than in the city, and is 1.2 times higher in the Amur region than in the Russian Federation. Conclusion. Appropriate treatment and prevention measures are recommended for further improvement of medical care for breast cancer patients in the Amur region
COMBINED MODALITY TREATMENT INCLUDING LOCAL HYPERTHERMIA IN PATIENTS WITH LOCALLY-ADVANCED LARYNGEAL AND LARYNGOPHARYNGEAL CANCER
The paper presents two-year results of combined modality treatment of patients with stage IIIβIV (T3N0β1M0) locally advanced laryngeal and laryngopharyngeal cancer. In the first phase of the treatment, all 24 patients included into the study, received preoperative RT with local hyperthermia. Preventive tracheostoma was not an obstacle for the treatment. Patients who achieved partial response or stable disease underwent surgery. In case of complete tumor regression (n=5), radiotherapy was continued up to the total dose of 66 Gy. Histological examination of surgical specimens revealed complete pathological response in all patients who received combined modality treatment. Regional metastases were revealed in 2 patients, and they subsequently underwent lymph node dissection. The overall 2-year survival rate was 100 % and 2-year metastasis-free survival was 91.7 %