2 research outputs found
ΠΠΈΡΠΎΠ²ΡΠ΅ ΡΠΌΡΠ»ΡΡΠΈΠΈ ΡΡΠ΅ΡΡΠ΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ Π² ΡΠΎΡΡΠ°Π²Π΅ ΠΏΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΈΡΠ°Π½ΠΈΡ ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Objective: to study the efficacy of third- versus secondary-generation fatty emulsions as part of parenteral nutrition in patients operated on for gastric cancer. Subjects and methods. Envelope randomization was used to make up two groups, each comprising 10 patients, operated on for gastric cancer in the scope of gastrectomy. A control group received parenteral nutrition having the following components: Lipofundin MST/LST 20%, (500 ml daily) + Nutriflex 48/150 (B. Braun) (1000 ml daily, 1744 kcal/day). The study group patients were given Lipoplus 20% (500 ml daily) + Nutriflex 48/150 (1000 ml daily, 1745 kcal/day). Parenteral nutrition was used on postoperative days 1 to 5. Results. Nutritional status evaluation revealed a significant increase in the concentration of total protein and albumin in the control and study group patients on postoperative day 6. The use of both second- and third-generation fatty emulsions caused a significant increase in the concentration of triglycerides on day 6 after surgery; no differences were found between the groups. On day 6 following surgery, there was a significant decrease in IL-4 in both groups (p<0.05). At the same time the Lipofundin MST/LST group showed a significantly lower concentration of IL-4 than did the study group (p<0.05). After termination of a parenteral nutrition course, the study and control groups showed a significant decrease in one of the major pro-inflammatory cytokines β IL-6. Conclusion. In the study group, the serum anti-inflammatory activity of IL-4 was more evident than that in the control group and the proinflammatory activity (IL-6 concentration) decreased, which can support that as compared with the second-generation fatty emulsions, third-generation ones with a balanced omega 3 to omega-6 fatty acid ratio (1:2.7) had a normalizing effect on systemic inflammatory processes and cytokine balance with increased anti-inflammatory and reduced proinflammatory activities. Key words: third-generation fatty emulsions, omega-3/omega-6 fatty acids, pro and anti-inflammatory cytokines.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ . ΠΠ·ΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΆΠΈΡΠΎΠ²ΡΡ
ΡΠΌΡΠ»ΡΡΠΈΠΉ ΡΡΠ΅ΡΡΠ΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ Π² ΡΠΎΡΡΠ°Π²Π΅ ΠΏΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΈΡΠ°Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎ ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ ΡΠ°ΠΊΠ° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΠΆΠΈΡΠΎΠ²ΡΠΌΠΈ ΡΠΌΡΠ»ΡΡΠΈΡΠΌΠΈ Π²ΡΠΎΡΠΎΠ³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ΅ΠΌ ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΊΠΎΠ½Π²Π΅ΡΡΠΎΠ² ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΎ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ ΠΏΠΎ 10 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΉ, ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎ ΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ ΡΠ°ΠΊΠ° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π² ΠΎΠ±ΡΠ΅ΠΌΠ΅ Π³Π°ΡΡΡΡΠΊΡΠΎΠΌΠΈΠΈ. Π ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΏΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΠΈΡΠ°Π½ΠΈΠ΅ Π² ΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΌ ΡΠΎΡΡΠ°Π²Π΅: Β«ΠΠΈΠΏΠΎΡΡΠ½Π΄ΠΈΠ½ ΠΠ‘Π’/ΠΠ‘Π’Β» 20% β 500 ΠΌΠ» Π² ΡΡΡΠΊΠΈ + Β«ΠΡΡΡΠΈΡΠ»Π΅ΠΊΡ 48/150Β» (B. Braun) β 1000 ΠΌΠ» Π² ΡΡΡΠΊΠΈ (1744 ΠΊΠΊΠ°Π»/ΡΡΡ). ΠΠ°ΡΠΈΠ΅Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Β«ΠΠΈΠΏΠΎΠΏΠ»ΡΡΒ» 20% β 500 ΠΌΠ» Π² ΡΡΡΠΊΠΈ + Β«ΠΡΡΡΠΈΡΠ»Π΅ΠΊΡ 48/150Β» β 1000 ΠΌΠ» Π² ΡΡΡΠΊΠΈ (1745 ΠΊΠΊΠ°Π»/ΡΡΡ). ΠΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ Ρ ΠΏΠ΅ΡΠ²ΡΡ
ΠΏΠΎ ΠΏΡΡΡΠ΅ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΡΡΠΊΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ΅Π½ΠΊΠ° Π½ΡΡΡΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° Π²ΡΡΠ²ΠΈΠ»Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΎΠ±ΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ° ΠΈ Π°Π»ΡΠ±ΡΠΌΠΈΠ½Π° Π½Π° 6-Π΅ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΡΡΠΊΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ Π³ΡΡΠΏΠΏ. ΠΡΠΌΠ΅ΡΠ΅Π½Π° Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½Π°Ρ ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΈΡΠ°Π½ΠΈΡ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
. ΠΠ°Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ ΡΠΌΡΠ»ΡΡΠΈΠΈ, ΠΊΠ°ΠΊ Π²ΡΠΎΡΠΎΠ³ΠΎ, ΡΠ°ΠΊ ΠΈ ΡΡΠ΅ΡΡΠ΅Π³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠΌ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΡΠΈΠ³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ² Π½Π° 6-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠ°Π·Π»ΠΈΡΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ. ΠΠΎΠ»ΡΡΠ΅Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ IL-4 Π½Π° 6-Π΅ ΡΡΡ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
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