217 research outputs found
Pharmacological evaluation polysaccharide complex flowers tansy
From flowers tansy extracted polysaccharide complex. Installed its qualitative and quantitative composition, have developed a technique standardizing the content of reducing sugars. By thin layer chromatography and high pressure liquid chromatography after acid hydrolysis installed monosaccharide composition: glucose, xylose, arabinose, galactose and mannose. It is proved that the polysaccharide has a high content of uronic acid, which allows it to include the class of pectin. The investigation of gastroprotective activity of polysaccharide in the prophylactic administration at model destruction of the gastric mucosa to indomethacin. Introduction polysaccharide prevents various types of erosive and ulcerative destruction. According to anti-ulcer activity of the drug is superior to ranitidine and comparable to omeprazol
Clinical Signs and Medical History as Predictors of Enalapril-Associated Dry Cough in Cardiovascular Patients
Angiotensin-converting enzyme inhibitors (ACEIs) are among the most prescribed and effective medicinal products for the treatment of several cardiovascular diseases. According to a number of studies, 30% of patients taking ACEIs develop adverse drug reactions (ADRs), and treatment discontinuation is often required as a result. The most common ADR associated with ACEIs is a dry (non-productive) cough. Nevertheless, the clinical signs and medical history predictive of this ADR in cardiovascular patients are still understudied.The aim of the study was to analyse the clinical signs and medical history predictive of cough in patients with cardiovascular conditions treated with enalapril.Materials and methods. The study was carried out in 2019β2022 and enrolled 224 patients with essential hypertension (grades 2 and 3) treated with enalapril at a dose of 10β20Β mg/day. The patients were assigned to 2Β groups: Group 1 included 113 patients with enalapril-associated cough, while Group 2 (control group) comprised 104Β patients without this ADR. At screening, all the patients underwent a general examination and a check of their allergy and medication history. Using the data obtained, the authors analysed the association of the clinical signs and medical history with the ADR of interest (dry cough).Results. In contrast to the control group, the group with ACEI-associated dry cough included more patients with a history of drug-induced toxicoderma (OR=5.639, CI 2.234β14.236, Ο2=15.845, and p<0.001) or type 2 diabetes mellitus (OR=3.409, CI 1.461β7.953, Ο2=8.7472, and p<0.01), a family history of bronchial asthma (OR=4.141, CI 2.066β8.299, Ο2=17.417, and p<0.001), and a close family history of severe allergic reactions (OR=3.714, CI 1.720β 8.018, Ο2=12.137, and p<0.001).Conclusions. A family history of allergy increases the probability of dry cough in patients taking ACEIs. In order to improve the safety of ACEI therapy, patients with cardiovascular conditions should be asked more detailed questions about their personal or first-degree family history of allergy
The prevalence of serological markers of viral hepatitis among labor migrants arriving in the Russian Federation
Aim. To determine of the prevalence of viral hepatitis A, E, B, C and D markers in migrant workers.Materials and methods. Blood serum samples from 1,333 migrant workers recently arrived in Russia from Uzbekistan (n = 464), Tajikistan (n = 415), Ukraine (n = 308) and Moldova (n = 146) were analyzed. Anti-HAV IgG, anti-HEV IgM and IgG, HBsAg, anti-HBV and anti-HCV were tested using commercial ELISA tests.Results. The frequency of HBsAg detection was significantly higher among migrants from Tajikistan and Uzbekistan (5,3% and 5,2%, respectively) compared to migrants from Ukraine (1,0%) and Moldova (3,4%). No anti-HDV was detected in any positive HBsAg sample. The rate of anti-HCV detection was high regardless of the country of origin: 4,5% (Uzbekistan), 4.8% (Tajikistan), 3,9% (Ukraine), 4,8% (Moldova). Anti-HEV IgG was significantly higher in migrants from Uzbekistan and Tajikistan compared to those from Ukraine and Moldova (25,4% and 43,1%, vs. 7,8% and 12,3%, respectively, p <0,05). Anti-HEV IgM, indicative of current or recent infection, was detected in migrants from Uzbekistan, Tajikistan, Ukraine and Moldova with similar frequency β 3,9%, 7,8%, 5,8% and 6,8%, respectively. AntiHAV IgG positivity rate was significantly lower in migrants from Ukraine compared to those from Moldova, Uzbekistan and Tajikistan (70,1% versus 91,8%, 98,7%, 99,8%, respectively, p <0,05).Conclusion. The high prevalence of hepatitis B and C serologic markers in labor migrants, as well as anti-HEV IgM, suggests a high probability of the importation of HCV, HBV and HEV in the Russian Federation. Thus, inclusion of hepatitis B, C and E testing into routine screening of labor migrants might be beneficial
Efficiency of treatment of laryngopharyngeal reflux with proton pump inhibitors depending on the <i>CYP2C19</i> polymorphism
Introduction. A treatment for LFR for many years, the superiority of PPIs over placebos is still controversial. Of particular clinical importance is the metabolic rate of PPIs in hepatocytes using the cytochrome P450 system with the participation of the isoenzyme CYP2C19 and partially CYP3A4Πim. We set a goal to study the efficacy of omeprazole 20 mg in the treatment of LFR symptoms without esophageal syndrome in patients with gastroesophageal reflux (GERD), depending on the polymorphism of the CYP2C19 genotype.Πaterials and ΠΌethods. After the exclusion criteria, 100 people took part in the study, 94 people completed the study.Results. According to the results, 26.6% of patients in the study group (residents of the Moscow region) with LFR symptoms without esophageal syndrome belong to fast metabolizers of CYP2C19, 4.2% to ultrafast metabolizers, 52.1% to normal metabolizers, 16% to intermediate metabolizers and 1.1% to slow CYP2C19.Conclusions. In patients with a rapid metabolism, within 1 month after discontinuation of omeprazole, it is necessary to increase the amount of omeprazole 20 mg intake up to 2 times a day in the morning and in the evening and reduce the duration of treatment to 6 weeks
ΠΠ½Π°Π»ΠΈΠ· ΡΡΡΡΠΊΡΡΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠ΅ΠΌΠΈΠΉ ΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ², Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡΡ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΈ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΡΠΊΠΎΡΠΎΠΏΠΎΠΌΠΎΡΠ½ΠΎΠΌ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ΅ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2003 ΠΏΠΎ 2021 Π³.: ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅
ΠΠΠ’Π£ΠΠΠ¬ΠΠΠ‘Π’Π¬: Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π±Π΅Π· Π°Π½Π°Π»ΠΈΠ·Π° Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊΒ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ. Π¦ΠΠΠ¬ ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ―: ΠΠ½Π°Π»ΠΈΠ· ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ Π²Π΅Π΄ΡΡΠΈΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Π±Π°ΠΊΡΠ΅ΡΠΈΠ΅ΠΌΠΈΠΉ Π²Β ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΈ ΠΈΒ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (ΠΠ ΠΠ’) Π²Β ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΒ 2003 ΠΏΠΎ 2021Β Π³. ΠΈΒ ΠΈΡ
ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊΒ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ; ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠΏΠΎΠ² ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠ°Π· ΡΒ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉΒ β Klebsiella pneumoniae ΠΈΒ Acinetobacter baumannii. ΠΠΠ’ΠΠ ΠΠΠΠ« Π ΠΠΠ’ΠΠΠ«: ΠΒ Π°Π½Π°Π»ΠΈΠ· Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π²ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΡ, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΠ΅ ΠΈΠ· ΠΊΡΠΎΠ²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π½Π°Ρ
ΠΎΠ΄ΠΈΠ²ΡΠΈΡ
ΡΡ ΠΠ ΠΠ’ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ, ΡΠ°ΡΡΡΠΈΡΠ°Π½Π½ΠΎΠΌ Π½Π° 12Β ΠΊΠΎΠ΅ΠΊ, Π²Β ΡΠΊΠΎΡΠΎΠΏΠΎΠΌΠΎΡΠ½ΠΎΠΌ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ΅ Π³.Β ΠΠΎΡΠΊΠ²Ρ Π²Β ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΒ 2003 ΠΏΠΎ 2021Β Π³. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΈΒ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊΒ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π²Β Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ Π°Π½Π°Π»ΠΈΠ·Π°ΡΠΎΡΠ΅ PHOENIX ΠΈΒ ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π΄ΠΈΡΠΊΠΎ-Π΄ΠΈΡΡΡΠ·ΠΈΠΎΠ½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ. ΠΠ΅ΡΠ΅ΠΊΡΠΈΡ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠ°Π· ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ. Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π«: ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 17Β 034 ΠΎΠ±ΡΠ°Π·ΡΠ° ΠΊΡΠΎΠ²ΠΈ, ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
Π±ΡΠ»ΠΎ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΎ 6372 ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΒ ΡΠΊΠ°Π·Π°Π½Π½ΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ Π΄ΠΎΠ»Ρ Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ²Π΅Π»ΠΈΡΠΈΠ»Π°ΡΡ ΡΒ 21,0 Π΄ΠΎ 52,8Β %, ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π·Π° ΡΡΠ΅Ρ K.Β pneumoniae (1,0β24,5Β %) ΠΈΒ A.Β baumannii (0β9,1Β %). Π£ΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΡΡΠΈΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊΒ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠ°ΠΌ ΡΒ 2008 ΠΏΠΎ 2021Β Π³. Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ»Π°ΡΡ: K.Β pneumoniaeΒ β ΡΒ 2,3 Π΄ΠΎ 70,3Β %, A.Β baumanniiΒ β ΡΒ 7,5 Π΄ΠΎ 99,5Β %. Π¨ΡΠ°ΠΌΠΌΡ K.Β pneumoniae ΠΏΡΠΎΠ΄ΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΡΠΈΠΏΡ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠ°Π·: OXA-48 (73,8Β %), KPC (6,2Β %), NDM (1,5Β %), NDMΒ +Β OXA-48 (15,4Β %), KPCΒ +Β OXA-48 (3,1Β %). ΠΡΠ΅ ΡΡΠ°ΠΌΠΌΡ A.Β baumannii ΠΏΡΠΎΠ΄ΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠ°Π·Ρ OXA-40. ΠΡΠΎΠ΄ΡΡΠ΅Π½ΡΡ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠ°Π·Ρ OXA-48 Π±ΡΠ»ΠΈ ΡΡΡΠΎΠΉΡΠΈΠ²Ρ ΠΊΒ ΠΊΠΎΠ»ΠΈΡΡΠΈΠ½Ρ ΠΈΒ ΡΠΈΠ³Π΅ΡΠΈΠΊΠ»ΠΈΠ½Ρ Π²Β 14,6 ΠΈΒ 44,8Β % ΡΠ»ΡΡΠ°Π΅Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, ΠΊΒ ΡΠ΅ΡΡΠ°Π·ΠΈΠ΄ΠΈΠΌΡ/Π°Π²ΠΈΠ±Π°ΠΊΡΠ°ΠΌΡΒ β Π²Β 4,2Β % ΡΠ»ΡΡΠ°Π΅Π². ΠΠ«ΠΠΠΠ«: Π£Π²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ Π²Β ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΡΡΠ΅Π΄ΠΈ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΡΡΠΈΡ
Π²Β Π±Π°ΠΊΡΠ΅ΡΠΈΠ΅ΠΌΠΈΠΈ Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠ΅Π½Ρ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ Π²Β ΠΠ ΠΠ’. ΠΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΡΡΠ°ΠΌΠΌΠΎΠ² K.Β pneumoniae Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡΡ ΠΈΒ ΠΎΠΊΠΎΠ»ΠΎ 10Β %Β β ΡΠΊΡΡΡΠ΅ΠΌΠ°Π»ΡΠ½ΠΎΠΉ, ΠΈΠ»ΠΈ ΠΏΠ°Π½ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡΡ. ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ A.Β baumannii ΠΎΡΠ½ΠΎΡΡΡΡΡ ΠΊΒ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΡΠΊΡΡΡΠ΅ΠΌΠ°Π»ΡΠ½ΠΎ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΠΠ€Π€ΠΠΠ’ΠΠΠΠΠ‘Π’Π¬ ΠΠ ΠΠΠΠΠΠΠΠ― ΠΠΠ ΠΠΠΠΠΠ Π‘ ΠΠΠΠΠΠΠ’ΠΠ ΠΠ Π£Π ΠΠΠΠ« ΠΠ ΠΠΠ Π’ΠΠ€ΠΠΠ
In the he article are presented the research result on effectiveness of application new form of urea on potato. New urea form is urea with urease inhibitors. This fertilities type allow to reduce losses of nitrogen in ammonium form. Field experiment was carried out in 2017 on solonetc light chestnut soils with heavy granulometric compound in the conditions of the Volgograd region in the experimental polygon of the lower Volga agricultural research Institute β branch of Federal state budgetary scientific institution "Federal scientific center for agro-ecology, integrated land reclamation and protective afforestation wounds". As an object of research used potatoes mid-early table varieties Nevsky. The advantage of a new fertilizer form is the yield increase and improvement of tubers quality. Urea UTEC application leads to formation bigger and uniform tuber size. The use of urea UTEC provide the potato yield of 56.4 t/ha, with marketable tubers fraction up to 54.82 t/ha, the total yield increase to the control β 35.6%, in monetary terms this amounted to 245887.0 RUB/ha additional profit. Under these conditions, was obtained lowest amount of non-marketable yield β 0.16 t/ha, which is 2.65 times less than in the control variant. The advantage of urea UTEC application in comparison with ammonium nitrate was the increase in the yield of marketable potatoes by 5.1 t/ha and an additional profit up to 76.8 thousand rubles/ha. The Assessment of the potato quality showed that the best treatment was also the treatment with UTEC urea, the starch content in tubers was 9.22%. Note that almost the same value of the indicator in the variant with the use of urea (option 2), and the lowest starch content was noted when using ammonium nitrate β 9.05%.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π° Ρ Π΄ΠΎΠ±Π°Π²ΠΊΠΎΠΉ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ° ΡΡΠ΅Π°Π·Ρ β UTEC Π½Π° ΠΏΠΎΡΠ°Π΄ΠΊΠ°Ρ
ΠΊΠ°ΡΡΠΎΡΠ΅Π»Ρ. ΠΠΎΠ»Π΅Π²ΠΎΠΉ ΠΎΠΏΡΡ Π±ΡΠ» Π·Π°Π»ΠΎΠΆΠ΅Π½ Π² 2017 Π³ΠΎΠ΄Ρ Π½Π° ΡΠΎΠ»ΠΎΠ½ΡΠ΅Π²Π°ΡΠΎΠΉ ΡΠ²Π΅ΡΠ»ΠΎ-ΠΊΠ°ΡΡΠ°Π½ΠΎΠ²ΠΎΠΉ ΠΏΠΎΡΠ²Π΅ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ Π³ΡΠ°Π½ΡΠ»ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΠΎΠ»Π³ΠΎΠ³ΡΠ°Π΄ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π½Π° ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠ³ΠΎΠ½Π΅ ΠΠΈΠΆΠ½Π΅-ΠΠΎΠ»ΠΆΡΠΊΠΎΠ³ΠΎ ΠΠΠΠ‘Π₯ β ΡΠΈΠ»ΠΈΠ°Π» Π€ΠΠΠΠ£ Β«Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΡΠΉ Π½Π°ΡΡΠ½ΡΠΉ ΡΠ΅Π½ΡΡ Π°Π³ΡΠΎΡΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΡ
ΠΌΠ΅Π»ΠΈΠΎΡΠ°ΡΠΈΠΉ ΠΈ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠΎΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΡ Π ΠΠΒ». Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΠ±ΡΠ΅ΠΊΡΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΊΠ°ΡΡΠΎΡΠ΅Π»Ρ ΡΡΠ΅Π΄Π½Π΅ΡΠ°Π½Π½ΠΈΠΉ ΡΡΠΎΠ»ΠΎΠ²ΡΠΉ ΡΠΎΡΡΠ° ΠΠ΅Π²ΡΠΊΠΈΠΉ. ΠΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²ΠΎ Π½ΠΎΠ²ΠΎΠΉ ΡΠΎΡΠΌΡ ΡΠ΄ΠΎΠ±ΡΠ΅Π½ΠΈΡ Π² ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠΈ ΡΡΠΎΠΆΠ°Ρ ΠΊΠ»ΡΠ±Π½Π΅ΠΉ ΠΈ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΈΡ
ΠΊΠ°ΡΠ΅ΡΡΠ²Π°. ΠΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π° UTEC ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ ΡΡΠΎΠΆΠ°ΠΉ ΠΊΠ»ΡΠ±Π½Π΅ΠΉ Ρ Π½Π°ΠΈΠ»ΡΡΡΠΈΠΌ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ°ΠΊΡΠΈΠΉ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π° UTEC ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ»ΠΎ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠΆΠ°ΠΉΠ½ΠΎΡΡΠΈ ΠΊΠ°ΡΡΠΎΡΠ΅Π»Ρ 56,4 Ρ/Π³Π°, ΠΌΠ°ΡΡΠ° ΡΠΎΠ²Π°ΡΠ½ΡΡ
ΠΊΠ»ΡΠ±Π½Π΅ΠΉ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 54,82 Ρ/Π³Π°, ΠΎΠ±ΡΠ°Ρ ΠΏΡΠΈΠ±Π°Π²ΠΊΠ° ΡΡΠΎΠΆΠ°Ρ ΠΊ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ β 35,6%, Π² Π΄Π΅Π½Π΅ΠΆΠ½ΠΎΠΌ Π²ΡΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΡΡΠΎ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 245887,0 ΡΡΠ±/Π³Π° Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΈΠ±ΡΠ»ΠΈ. Π ΡΡΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΎΡΠΌΠ΅ΡΠ΅Π½ Π½Π°ΠΈΠΌΠ΅Π½ΡΡΠΈΠΉ Π²ΡΡ
ΠΎΠ΄ ΡΡΡΠ°ΠΆΠ½ΠΎΠΉ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ 0,16 Ρ/Π³Π°, ΡΡΠΎ Π² 2,65 ΡΠ°Π· ΠΌΠ΅Π½ΡΡΠ΅, ΡΠ΅ΠΌ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΌ Π²Π°ΡΠΈΠ°Π½ΡΠ΅. ΠΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π° UTEC Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ Π°ΠΌΠΌΠΈΠ°ΡΠ½ΠΎΠΉ ΡΠ΅Π»ΠΈΡΡΠΎΠΉ, ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠΆΠ°Ρ ΡΠΎΠ²Π°ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°ΡΡΠΎΡΠ΅Π»Ρ Π½Π° 5,1 Ρ/Π³Π° ΠΈ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΈΠ±ΡΠ»ΠΈ 76,8 ΡΡΡ. ΡΡΠ±/Π³Π°. ΠΡΠ΅Π½ΠΊΠ° ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΊΠ°ΡΡΠΎΡΠ΅Π»Ρ ΠΏΠΎΠΊΠ°Π·Π°Π»Π°, ΡΡΠΎ Π½Π°ΠΈΠ»ΡΡΡΠΈΠΌ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠΌ Π±ΡΠ» ΡΠ°ΠΊΠΆΠ΅ Π²Π°ΡΠΈΠ°Π½Ρ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π° UTEC, ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π° Π² ΠΊΠ»ΡΠ±Π½ΡΡ
ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 9,22%. ΠΡΠΌΠ΅ΡΠΈΠΌ, ΡΡΠΎ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΡΠ°ΠΊΠ°Ρ ΠΆΠ΅ Π²Π΅Π»ΠΈΡΠΈΠ½Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π² Π²Π°ΡΠΈΠ°Π½ΡΠ΅ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π° (Π²Π°ΡΠΈΠ°Π½Ρ 2), Π° Π½Π°ΠΈΠΌΠ΅Π½ΡΡΠ΅Π΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π° ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π°ΠΌΠΌΠΈΠ°ΡΠ½ΠΎΠΉ ΡΠ΅Π»ΠΈΡΡΡ β 9,05%
Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis
Aim. To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial fibrillation and deep vein thrombosis.Material and methods. Patients hospitalized at Yudin State Clinical Hospital participated in the study. A total of 92 patients (50 patients received apixaban and 42 β rivaroxaban) with non-valvular atrial fibrillation and deep vein thrombosis were included. Genotyping was performed by real-time polymerase chain reaction. Direct oral anticoagulants concentrations were measured using an electrospray ionization mass spectrometer in positive ionization mode.Results. In our study we found that in patients carrying the CT+TT ABCB1 (rs4148738) C>T genotype encoding the carrier protein (P-gp), the plasma concentration of rivaroxaban was statistically significantly higher p= 0.026. In addition, we found that patients taking apixaban together with a CYP3A4/P-gp inhibitor were 3.5 times more likely to have hemorrhagic complications than those without inhibitors p = 0.004.Conclusion. Our study revealed that the plasma concentration of rivaroxaban was higher in patients carrying the ABCB1 (rs4148738) C>T polymorphism T allele. And patients taking apixaban together with CYP3A4/P-gp inhibitor had higher risk of hemorrhagic complications in comparison with patients not taking such drugs. Further studies are needed on the influence of pharmacogenetics and pharmacokinetics on the safety and efficacy profile of apixaban and rivaroxaban, taking into account the trend of systemic approach to optimization of anticoagulant therapy of direct oral anticoagulants based on pharmacokinetic, pharmacogenetic biomarkers
Π ΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ Π²Π΅Π½ΠΎΠ·Π½ΡΡ ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Ρ ΠΏΠΎΠΆΠΈΠ»ΡΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Aim. To evaluate venous thromboembolic complication risk in elderly patients admitted to trauma and orthopedics departments, prevalence of comorbidity, its impact on the risk of thrombotic events, efficacy and safety of prophylactic anticoagulant therapy.Materials and methods. Authors performed a retrospective analysis of medical records of 120 patients aged 65 years and over. Analyzed data included demographic data, main diagnosis, co-existing pathology according to International Classification of Diseases X, type of surgery and anticoagulant prophylaxis. Risk of development of venous thromboembolic complications was assessed by the Caprini scale. Potential drug-drug interactions were checked using Drug Interaction Checker available, created by company Cerner Multum according to FDA recommendations.Results. The most frequent causes of hospitalization were destructive large joint arthritis (40%) and fractures of lower extremities (21.7%). Surgeries with an average duration of 87 Β± 31.4 min were performed in 85% of patients, of which major surgery β 68.6%, minor β 31.4%. Comorbidity was detected in 90% of elderly patients admitted to hospital because of pathology of the musculoskeletal system. Pathology of musculoskeletal system most often was combined with cardiovascular diseases (81.7%). A moderate risk of venous thromboembolic complications was detected in 10% patients, high risk in 75%. Anticoagulant prophylaxis with a direct factor Xa inhibitor rivaroxaban or low-molecular weight heparin enoxaparine sodium was performed in 80% of patients.Conclusion. The study demonstrated that 75% of elderly patients with pathology of the musculoskeletal system are at high risk for the development of venous thromboembolic complications. The main risk factors include the type and duration of surgery and comorbidity.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²Π΅Π½ΠΎΠ·Π½ΡΡ
ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Ρ ΠΏΠΎΠΆΠΈΠ»ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ, ΠΈΠ·ΡΡΠΈΡΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΈ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΠΈ, Π΅Π΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠΈΡΠΊ ΡΡΠΎΠΌΠ±ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠ°ΠΌΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΈΡΡΠΎΡΠΈΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ 120 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΡΠ°ΡΡΠ΅ 65 Π»Π΅Ρ ΠΈ 64 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΌΠΎΠ»ΠΎΠΆΠ΅ 65 Π»Π΅Ρ, ΠΏΠΎΡΡΡΠΏΠΈΠ²ΡΠΈΡ
Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΎΡΡΠΎΠΏΠ΅Π΄ΠΈΠΈ ΠΌΠ½ΠΎΠ³ΠΎΠΏΡΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ°. Π£ΡΠΈΡΡΠ²Π°Π»ΠΈ Π΄Π΅ΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅, ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΠ·, ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΡΡΠ±ΡΠΈΠΊΠ°ΠΌ ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ Π₯ ΠΏΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠ°, Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ Π²Π΅Π½ΠΎΠ·Π½ΡΡ
ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. Π ΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠΎΠΌΠ±ΠΎΠ·ΠΎΠ² ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ ΡΠΊΠ°Π»Π΅ Caprini, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ β Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΈΠ½ΡΠ΅ΡΠ½Π΅Ρ-ΡΠ΅ΡΡΡΡΠ° Drug Interaction Checker Π½Π° ΡΠ°ΠΉΡΠ΅ www.drugs.com.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΌΠΈ ΠΏΡΠΈΡΠΈΠ½Π°ΠΌΠΈ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠΆΠΈΠ»ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ²Π»ΡΠ»ΠΈΡΡ Π°ΡΡΡΠΎΠ·Ρ ΠΊΡΡΠΏΠ½ΡΡ
ΡΡΡΡΠ°Π²ΠΎΠ² (40%), ΠΏΠ΅ΡΠ΅Π»ΠΎΠΌΡ ΠΏΠΎΡΡΠ½ΠΈΡΠ½ΠΎ-ΠΊΡΠ΅ΡΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° ΠΏΠΎΠ·Π²ΠΎΠ½ΠΎΡΠ½ΠΈΠΊΠ°, Π±Π΅Π΄ΡΠ΅Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠΈ ΠΈ ΠΊΠΎΡΡΠ΅ΠΉ ΡΠ°Π·Π° (21,7%). ΠΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΡΠΎ ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ (87 Β± 31,4) ΠΌΠΈΠ½ Π²ΡΠΏΠΎΠ»Π½Π΅Π½Ρ 85% Π±ΠΎΠ»ΡΠ½ΡΠΌ: Π±ΠΎΠ»ΡΡΠΈΠ΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ β 58,3%, ΠΌΠ°Π»ΡΠ΅ β 26,7%. ΠΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ Ρ 90% Π±ΠΎΠ»ΡΠ½ΡΡ
. Π§Π°ΡΠ΅ Π²ΡΠ΅Π³ΠΎ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΊΠΎΡΡΠ½ΠΎ-ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΡΠ΅ΡΠ°Π»ΠΈΡΡ Ρ Π±ΠΎΠ»Π΅Π·Π½ΡΠΌΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΡΠΎΠ²ΠΎ- ΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ (81,7%). ΠΡΡΠΎΠΊΠΈΠΉ ΡΠΈΡΠΊ Π²Π΅Π½ΠΎΠ·Π½ΡΡ
ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π²ΡΡΠ²Π»Π΅Π½ Ρ 75% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΠΉ β Ρ 10%. ΠΠ»Ρ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΡΡΠΎΠΌΠ±ΠΎΠ·ΠΎΠ² 80% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ Π½Π°Π·Π½Π°ΡΠ°Π»ΠΈ ΠΏΡΡΠΌΠΎΠΉ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡ ΡΠ°ΠΊΡΠΎΡΠ° Π₯Π° ΡΠΈΠ²Π°ΡΠΎΠΊΡΠ°Π±Π°Π½ ΠΈΠ»ΠΈ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ Π³Π΅ΠΏΠ°ΡΠΈΠ½ ΡΠ½ΠΎΠΊΡΠ°ΠΏΠ°ΡΠΈΠ½ Π½Π°ΡΡΠΈΡ. ΠΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΌΠΎΠ»ΠΎΠΆΠ΅ 65 Π»Π΅Ρ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ Π°ΡΡΡΠΎΠ·ΠΎΠ² ΠΈ ΠΏΠ΅ΡΠ΅Π»ΠΎΠΌΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π²Π½ΡΡΡΠΈΡΡΡΡΠ°Π²Π½ΡΡ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΊΠΎΠ»Π΅Π½Π°. ΠΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ (58,4 Β± 25,8) ΠΌΠΈΠ½ ΠΏΠΎΡΡΠ΅Π±ΠΎΠ²Π°Π»ΠΈΡΡ 51,6% Π±ΠΎΠ»ΡΠ½ΡΠΌ: Π±ΠΎΠ»ΡΡΠΈΠ΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ β 32,8%, ΠΌΠ°Π»ΡΠ΅ β 18,8%. ΠΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ Ρ 73,4%, Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ. ΠΡΡΠΎΠΊΠΈΠΉ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²Π΅Π½ΠΎΠ·Π½ΡΡ
ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π²ΡΡΠ²Π»Π΅Π½ Ρ 29,7%, ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΠΉ β Ρ 50,0%; 73% Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π»ΠΈ ΡΠ½ΠΎΠΊΡΠ°ΠΏΠ°ΡΠΈΠ½ Π½Π°ΡΡΠΈΡ ΠΈΠ»ΠΈ ΡΠΈΠ²Π°ΡΠΎΠΊΡΠ°Π±Π°Π½ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ (8,6 Β± 4,2) Π΄Π½Π΅ΠΉ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ 85% ΠΏΠΎΠΆΠΈΠ»ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ ΠΊΠΎΡΡΠ½ΠΎ-ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π²Π΅Π½ΠΎΠ·Π½ΡΡ
ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΡΠΈΡΠΊΠ° ΡΠ²Π»ΡΡΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΈ ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΡΡΡ
The rs11385942 and rs657152 variants are not associated with COVID-19 severity and outcomes in patients treated with favipiravir and remdesivir
Background. There is a mounting evidence in the scientific literature that susceptibility to SARS-CoV-2 infection could vary. The severity of COVID-19 symptoms can Β range from asymptomatic to severe respiratory failure, requiring prolonged artificial ventilation. The underlying causes of this range of clinical manifestations remain unclear. Identification of the risk factors that may cause this variation in clinical symptoms is important for identifying the most susceptible populations at highest risk. This should help improve prevention measures, reduce hospitalizations, and decrease the mortality rate of the disease. Previously, an association has been found between the severity of COVID-19 and the genetic markers rs11385942 G>GA and rs657152 A>C.The aim. To assess the impact of carrying polymorphic markers rs11385942 G>GA and rs657152 A>C on the severity of COVID-19 in patients undergoing specific therapy. Materials and methods. A total of 240 patients hospitalized with a coronavirus infection were included in the study. All patients received therapy with favipiravir or remdesivir. The presence of the rs11385942 G>GA and rs657152 A>C variants was determined in all patients. The study compared the length of hospital stays, frequency of patient transfers to the intensive care unit (ICU), and frequency of clinical outcomes (recovery or death) among carriers of allelic variants of the markers under investigation.Results. There were no significant associations between the carriage of variants rs11385942 G>GA and rs657152 A>C and the duration of patientsβ hospitalization, frequency of patient transfers to the ICU, and patient outcomes.Conclusion. The carriage of rs11385942 G>GA and rs657152 A>C variants did not affect the severity or type of clinical outcomes in patients with COVID-19
Drug-Induced Atrial Fibrillation / Atrial Flutter
Drug-induced atrial fibrillation / flutter (DIAF) is a serious and potentially life-threatening complication of pharmacotherapy. Purpose of the work: systematization and analysis of scientific literature data on drugs, the use of which can cause the development of DIAF, as well as on epidemiology, pathophysiological mechanisms, risk factors, clinical picture, diagnosis and differential diagnosis, treatment and prevention of DIAF. Analysis of the literature has shown that many groups of drugs can cause the development of DIAF, with a greater frequency while taking anticancer drugs, drugs for the treatment of the cardiovascular, bronchopulmonary and central nervous systems. The mechanisms and main risk factors for the development of DIAF have not been finally established and are known only for certain drugs, therefore, this section requires further study. The main symptoms of DIAF are due to the severity of tachycardia and their influence on the parameters of central hemodynamics. For diagnosis, it is necessary to conduct an electrocardiogram (ECG) and Holter monitoring of an ECG and echocardiography. Differential diagnosis should be made with AF, which may be caused by other causes, as well as other rhythm and conduction disturbances. Successful treatment of DIAF is based on the principle of rapid recognition and immediate discontinuation of drugs (if possible), the use of which potentially caused the development of adverse drug reactions (ADR). The choice of management strategy: heart rate control or rhythm control, as well as the method of achievement (medication or non-medication), depends on the specific clinical situation. For the prevention of DIAF, it is necessary to instruct patients about possible symptoms and recommend self-monitoring of the pulse. It is important for practitioners to be wary of the risk of DIAF due to the variety of drugs that can potentially cause this ADR
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