The effect of amber acid on the productivity and chemical composition of tomatoes grown in a climatic chamber

The research was carried out in 2019 - 2020 in the department of closed artificial agroecosystems for plant growing in the Federal State Budgetary Scientific Institution "Federal Scientific Agroengineering Center VIM", Moscow. The study focused on the seeds of tomatoes (Solanum lycopersicum L.) variety “Lyana”. Amber acid was used as a biostimulating factor at the stage of pre-sowing seed treatment and with constant drip irrigation of plants throughout the entire growing season - 145 day

Symmetries and modelling functions for diffusion processes

A constructive approach to theory of diffusion processes is proposed, which is based on application of both the symmetry analysis and method of modelling functions. An algorithm for construction of the modelling functions is suggested. This algorithm is based on the error functions expansion (ERFEX) of experimental concentration profiles. The high-accuracy analytical description of the profiles provided by ERFEX approximation allows a convenient extraction of the concentration dependence of diffusivity from experimental data and prediction of the diffusion process. Our analysis is exemplified by its employment to experimental results obtained for surface diffusion of lithium on the molybdenum (112) surface pre-covered with dysprosium. The ERFEX approximation can be directly extended to many other diffusion systems.Comment: 19 pages, 8 figure

Подготовка специалистов в области электронного маркетинга: кадры для цифровой экономики Республики Беларусь

The tendencies of development of marketing in conditions of digital transformation of economy are considered in the article. The concept of electronic marketing is presented. The condition of training of specialists in the field of electronic marketing in the Republic of Belarus is described. The necessity of training of specialists in the field of e-marketing on the second stage of higher education is substantiated. The special features of this field of study are distinguished in comparison with the baccalaureate and in comparison with related directions of the master's programm. В статье рассматриваются тенденции развития маркетинга в условиях цифровой транс- формации экономики. Представлено понятие электронного маркетинга, дана характеристика состояния подготовки специалистов в области электронного маркетинга в Республике Беларусь. Обоснована необхо- димость открытия специальности «Электронный маркетинг» на II ступени высшего образования, выделены особен- ности данной специальности по сравнению с I ступенью и по сравнению со смежными направлениями подготовки магистров.

Role of Mosquitoes, <I>Culex</I> <I>pipiens</I> Complex, in West Nile Fever Virus Persistence in Urbanized Biocoenoses of Saratov

. In wiggler samples as well as in imago ones detected are WNF virus markers, which indicate the possibility of transovarial and trans-phase transmission of virus into mosquito populations, habitant in urbanized biocoenoses. It is substantiated that Culex pipiens female mosquitoes, which reproduce autogenically, provide for the persistence of the virus within the inter-epidemic period. Therewith there is a possibility of sustained, epidemically-active WNF micro-foci to be formed in the residential area landscapes, and this issue should be given proper consideration when performing assessment of the risks associated with urban population exposure to the infection

Conditions for Virus Circulation and Premises for Natural West Nile Fever Foci Formation in the Territory of the Saratov Region

Local climate change (rise of mean temperatures and amount of precipitation, prolongation of frost-free season) triggers further distribution, and increase in numbers of animals – carriers and vectors of West Nile fever virus in the territory of the Saratov region. Based on the results of ecological-epizootiological monitoring (2006–2012) traced out have been the species composition, abundance dynamics, and character of distribution of birds habitant in aquatic and anthropogenic complexes, mosquitoes and Ixodidae ticks. Investigated are possible causes of West Nile fever nosoarea expansion, related to ecology of migrating birds wintering in Africa. Persistent circulation of the virus in intra-zonal inundated biocoenosis facilitates formation of secondary natural foci of West Nile fever and factors into epidemic complications as regards this particularly dangerous vector-borne infection. On the basis of analytical data concerning hydrographic network density, fauna structure, population numbers of birds and mosquitoes – potential carriers and vectors of WNF, epizootiological and epidemiological surveillance, designed has been expectation-driven forecasting map chart which illustrates possibility of sustainable WNF foci formation in various territories of the Saratov region

Factors affecting the results of analgesic therapy. Results of the Russian multicentre study of NOTE (NSAID: Open-label Trial of Efficacy)

Non-steroidal anti-inflammatory drugs (NSAIDs) are most popular medications for the treatment of pain in common musculoskeletal diseases such as osteoarthritis (OA) and non-specific low back pain (LBP). However, the factors affecting the effectiveness of these drugs have not been determined fully. Aim: to identify factors affecting the effectiveness of NSAIDs in patients with OA and LBP. Materials and methods. An observational study was conducted to evaluate the effectiveness of a 2-week course of NSAIDs in OA and LBP in real clinical practice. The study group consisted of 3604 patients with OA and LBP (60.6% women and 39.4% men, mean age 55.0±13.4 years). According to the study design, aceclofenac (Airtal) and other NSAIDs used in the ratio 1:1. The main criterion of effectiveness was the frequency of complete pain relief after 2 weeks of therapy. In addition, the decrease of pain and general health were determined on a 10-point numerical rating scale (NRS). We compared the frequency of complete pain relief in patients who had and did not have the studied factors. The value of the studied factors was determined using OR (95% CI). Results and discussion. Most patients received aceclofenac (54.9%), as well as diclofenac (2.0%), ketoprofen (1.9%), lornoxicam (2.2%), meloxicam (13.7%), naproxen (2.1%), nimesulide (5.8%), celecoxib (5.9%), ethicoxib (7.1%) and other NSAIDs (4.4%); 56.2% of patients received muscle relaxants, mainly tolperisone (74.7%), vitamin B (10.4%), and proton pump inhibitors (42.8%). Complete pain relief was achieved in 54.8% of patients. The pain decrease and general health improvement were (for NRS) 63.9±13.4% and 61.7±14.8%, respectively. The efficacy of aceclofenac was slightly higher than in the whole group: complete pain relief was in 59.9% of patients. Adverse events in aceclofenac use were observed in 2.3% of patients, other NSAIDs-from 2.4 to 14.1%. The frequency of complete pain relief was higher in men: OR 1,239 (95% CI 1.08-1.418; p=0.002), who had the first episode of pain - OR 3.341 (95% CI 2.873-3.875; p=0.000), a good" response " to NSAIDs in history - OR 1.656 (95% CI 1.385-1.980; p=0.000) and received NSAIDs in combination with muscle relaxants - OR 1.218 (95% CI 1.067-1.390; p=0.004). The effect of therapy is lower in patients 65 years and older-OR 0,378 (95% CI 0.324-0.442; p=0,000), with body mass index >30 kg/m² - OR 0.619 (95% CI 0.529-0.723; p=0.000), with severe pain (≥7 points NRS) - OR 0.662 (95% CI 0.580-0.756; p=0.002), with pain at rest, - OR 0.515 (95% CI 0.450-0,589; p=0.000), pain at night - OR 0.581 (95% CI 0.501-0.672; p=0.000) and the presence of stiffness - OR 0.501 (95% CI 0.438-0,573; p=0.000). Treatment results are significantly worse in the cases of combination of LBP and joint pain, as well as pain in the trochanter major and pes anserinus area (

EVALUATION OF EXPRESSION OF 4 MIRNAS IN CYTOLOGICAL SAMPLES AS AN ADDITIONAL METHOD OF CERVICAL CANCER DIAGNOSIS

Introduction. Cervical cancer is the 4th most common cancer among women. The main screening method for cervical cancer is cytological examination of the cervical epithelium. This method allows to evaluate the level of cervical dysplasia (malignant potential) but it has several limitations and flaws. Development and implementation of new methods of molecular and genetic analysis in clinical practice can increase informational value of the traditional cytological examination and therefore objectivity in choosing treatment options.Objective is to develop and verify a new method of differential diagnosis of severe intraepithelial dysplasia and invasive cervical cancer.Materials and methods. The method is based on analysis of small non-coding RNA molecules (miRNAs) extracted from the material of traditional Pap smears. Based on literature search, 18 “marker” microRNA molecules were chosen and their expression levels were estimated in 166 samples of Pap smears from cervical canals with different cytological diagnoses. The analysis was performed using reverse transcription polymerase chain reaction.Results. Estimation of ratios between expression levels of miRNA pairs: 126/375; 20а/375; 126/145 allows to differentiate with high confidence borderline states of severe intraepithelial dysplasia and invasive cervical carcinoma (coefficients of quantitative interpretation of the error curve were 0.8, 0.75, 0.72, respectively).Conclusions. Analysis of miRNAs in Pap smear samples is a promising additional method of cervical cancer diagnosis. The method is objective and can be proposed as a supporting technique in cases when cytological examination doesn’t allow to differentiate between borderline pathological states of the cervical epithelium. Implementation of the method in clinical practice requires methodological optimization and additional validation using more clinical material

Studies of Biofilm Formation in Non-Pigmented and Plasmid-Deprived Mutants of <I>Yersinia pestis</I> on Biotic Surfaces, <I>in vivo</I> and <I>in vitro</I> Conditions

In non-pigmented and plasmid-deprived mutants – isogenic variants of highly virulent Yersinia pestis 231 strain – studied is the mechanism of biofilm formation on biotic surfaces, both in vitro (on the laboratory model of nematode Caenorhabdiitis elegans) and in vivo (inside the alimentary tract of Nosopsyllus laeviceps flea). It is determined that spontaneous loss of ability to form biofilms and generate pigmented colonies in the mutants is probably caused not only by the deletion of the whole chromosome pigmentation fragment, but also by a point(single base) mutation in structural hms operon. It is demonstrated that the absence of pCad, pFra or pPst plasmids does not have an impact on the ability of plasmid-deprived mutants to form biofilm on the cuticle of nematode C. elegans

Assessment of the Potential Epidemic Hazard as Regards International Public Events in Terms of the Currently Important Infectious Diseases

International public events (IPE) present some actual epidemiological problems requiring proper methodological elaboration. In this respect for the first time developed has been the scheme of assessment of their potential epidemic hazard (PEH), based on integrated evaluation of epidemiological risk as regards infectious diseases listed in the IHR (2005). On the cholera model demonstrated is the fact that high priority hazard of public events emerges when those are combined with such elements of epidemiological risk as territory and time of a threat, as well as risk factors and risk contingents. Thus the integral effect of all elements realization is manifested through high probability of infectious disease importation, which is associated with emergency situation, into the public event location and the disturbance of mass gathering progress. Reliability and functionality of the developed scheme is verified on other infections too. PEH assessment procedure allows for timely identification of priority goals, for rating means and capacities, organizational resources, methodological and technological arrays for the provision of sanitary-epidemiological welfare and biological safety when managing public event

Modern Conception of the Control over the Abundance of Carriers and Vectors of Plague in the Territory of the Russian Federation

Disinfestation and deratization remain the main ways of non-specific disease prophylaxis in natural plague foci. Modern strategies, tactics, methods and means of control over carriers and vectors of plague and associated infectious diseases are selected with due consideration to epidemiological potential of territories, epizootic activity of a foci, peculiarities of population ecology of animals that are of a medical significance, preservation of biodiversity in natural ecosystems, and the requirements for human and natural environments protection from pollutants