The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: The Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

Background: The effect of diet on age-related brain atrophy is largely unproven. Objectives: We aimed to explore the effect of a Mediterranean diet (MED) higher in polyphenols and lower in red/processed meat (Green-MED diet) on age-related brain atrophy. Methods: This 18-mo clinical trial longitudinally measured brain structure volumes by MRI using hippocampal occupancy score (HOC) and lateral ventricle volume (LVV) expansion score as neurodegeneration markers. Abdominally obese/dyslipidemic participants were randomly assigned to follow 1) healthy dietary guidelines (HDG), 2) MED, or 3) Green-MED diet. All subjects received free gym memberships and physical activity guidance. Both MED groups consumed 28 g walnuts/d (+440 mg/d polyphenols). The Green-MED group consumed green tea (3-4 cups/d) and Mankai (Wolffia-globosa strain, 100 g frozen cubes/d) green shake (+800 mg/d polyphenols). Results: Among 284 participants (88% men; mean age: 51 y; BMI: 31.2 kg/m2; APOE-ε4 genotype = 15.7%), 224 (79%) completed the trial with eligible whole-brain MRIs. The pallidum (-4.2%), third ventricle (+3.9%), and LVV (+2.2%) disclosed the largest volume changes. Compared with younger participants, atrophy was accelerated among those ≥50 y old (HOC change: -1.0% ± 1.4% compared with -0.06% ± 1.1%; 95% CI: 0.6%, 1.3%; P Conclusions: A Green-MED (high-polyphenol) diet, rich in Mankai, green tea, and walnuts and low in red/processed meat, is potentially neuroprotective for age-related brain atrophy.This trial was registered at clinicaltrials.gov as NCT03020186

Possible orthoor heterotopic transplantation of cryopreserved ovarian tissue

The article presents information on the possibilities for the cryopreservation of ovarian tissue with subsequent ortho - and heterotopic transplantation in patients receiving cytotoxic therapy

Asymptotic expansions of solutions of mixed type SDE driven by fractional Brownian motions for small times

In this paper we consider n-dimensional mixed type stochastic differential equations driven by multivariate fractional Brownian motions with Hurst indices greater than 1/3, standard Brownian motions and a drift term. Using a Taylor type development we obtain an expansion of expectations Ptg = Eg(X xt) for small t, where X xt denotes the solution of the mentioned stochastic differential equation with initial value x ∈ Rn, and g: Rn → R is a sufficiently smooth functio

MANAGEMENT OF PATIENTS WITH CERVICAL INSUFFICIENCY

The article presents a literature review on methods of diagnosis, therapy and management of patients with isthmic-cervical insufficiency. Risk factors for the development of isthmic-cervical insufficiency are the acquired and congenital anomalies of the cervix. The diagnosis can be made only during pregnancy. Shortening of cervical length <25 mm before 24 weeks indicates the presence of ICN and the significant risk of miscarriage. Initial evaluation of the cervical length is from 14 weeks. When finding a shortening of the length of the closed part of the cervical canal is less than 25 mm the treatment of choice is surgical correction. When the cervical length more than 25 mm prophylactically from 19 to 32 weeks assigned to micronized progesterone 200 mg vagina. In identifying ICN after 24 weeks, the method of choice is the appointment of micronized progesterone and the installation of an unloading obstetric pessary. The use of a differentiated algorithm of management of patients with ICN reduces the chance of unexpected premature birth and neonatal morbidity and mortality

Asymptotic expansions of solutions of mixed type SDE driven by fractional Brownian motions for small times

In this paper we consider n-dimensional mixed type stochastic differential equations driven by multivariate fractional Brownian motions with Hurst indices greater than 1/3, standard Brownian motions and a drift term. Using a Taylor type development we obtain an expansion of expectations Ptg = Eg(X xt) for small t, where X xt denotes the solution of the mentioned stochastic differential equation with initial value x ∈ Rn, and g: Rn → R is a sufficiently smooth functio