4 research outputs found
ΠΡΠ³ΠΈΠ½Π°Π·Π° II - Π½ΠΎΠ²Π°Ρ ΠΌΠΈΡΠ΅Π½Ρ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠΎΠ²
The article describes arginaseβs role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea. Two isoforms of arginase were found in the human organism. Arginase I is located in the cells cytoplasm and is predominantly expressed in the liver. Arginase II is a mitochondrial protein that is expressed in the kidney, prostatic gland and vascular wall. Arginase II hydrolyzes L-arginine, thereby reducing the synthesis of nitric oxide and leading to the development of endothelial dysfunction and a number of cardio-vascular disorders. Arginase is a promising pharmacological target in the treatment of endothelial dysfunction and a number of cardio-vascular diseases, though the development of highly-selective arginase II inhibitors is still a difficult task.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΡΠΎΠ»Ρ Π°ΡΠ³ΠΈΠ½Π°Π·Ρ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ ΡΡΠ΄Π° ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΡΠ³ΠΈΠ½Π°Π·Π° ΠΊΠ°ΡΠ°Π»ΠΈΠ·ΠΈΡΡΠ΅Ρ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ· L-Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π°, ΡΡΠ±ΡΡΡΠ°ΡΠ° Π΄Π»Ρ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ°, Π΄ΠΎ L-ΠΎΡΠ½ΠΈΡΠΈΠ½Π° ΠΈ ΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ. Π ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π΄Π²Π΅ ΠΈΠ·ΠΎΡΠΎΡΠΌΡ Π°ΡΠ³ΠΈΠ½Π°Π·Ρ. ΠΡΠ³ΠΈΠ½Π°Π·Π° I Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΡΠ΅ΡΡΡ Π² ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΡΠ³ΠΈΠ½Π°Π·Π° II - ΡΡΠΎ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΡΡΡ Π² ΠΏΠΎΡΠΊΠ°Ρ
, ΠΏΡΠΎΡΡΠ°ΡΠ΅, ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΡΠ΅Π½ΠΊΠ΅. ΠΡΠ³ΠΈΠ½Π°Π·Π° II Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΠΈΡΡΠ΅Ρ L-Π°ΡΠ³ΠΈΠ½ΠΈΠ½, ΡΠ½ΠΈΠΆΠ°Ρ ΡΠ΅ΠΌ ΡΠ°ΠΌΡΠΌ ΡΠΈΠ½ΡΠ΅Π· ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ°, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΠ΅Π»ΠΎΠ³ΠΎ ΡΡΠ΄Π° ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΡΠ³ΠΈΠ½Π°Π·Π° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΈΡΠ΅Π½ΡΡ Π² ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ ΡΠ΅Π»ΠΎΠ³ΠΎ ΡΡΠ΄Π° ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Π²ΡΡΠΎΠΊΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Π°ΡΠ³ΠΈΠ½Π°Π·Ρ II ΠΏΠΎ-ΠΏΡΠ΅ΠΆΠ½Π΅ΠΌΡ ΠΎΡΡΠ°Π΅ΡΡΡ ΡΡΡΠ΄Π½ΠΎΡΠ°Π·ΡΠ΅ΡΠΈΠΌΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅
Radiology methods of the sarcopenia diagnosis
One of the processes that accompany the aging of the body and the decline in the quality of life of older people is sarcopenia or loss of muscle tissue and the associated restriction of mobility. The identification of this condition in patients at the stage when there is only an initial decrease in muscle mass without a decrease in muscle strength is of great importance for determining the cause of the disease and the timely start of treatment. This review describes the capabilities of the methods of radiation diagnosis in assessing the quantity and quality of muscle tissue and their shortcomings from the standpoint of verification and dynamic observation of sarcopenia. The lack of a unified standard for the instrumental diagnosis of this pathology and the alertness of specialists regarding sarcopenia during routine examination is one of the main reasons for the insufficient detection of muscle loss in the cohort of elderly patients. This review is of interest to a wide range of clinical physicians and radiologists, who are found in their practice with patients of older age groups
Arginase II - a new target in the development of endothelium protectors
The article describes arginaseβs role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea. Two isoforms of arginase were found in the human organism. Arginase I is located in the cells cytoplasm and is predominantly expressed in the liver. Arginase II is a mitochondrial protein that is expressed in the kidney, prostatic gland and vascular wall. Arginase II hydrolyzes L-arginine, thereby reducing the synthesis of nitric oxide and leading to the development of endothelial dysfunction and a number of cardio-vascular disorders. Arginase is a promising pharmacological target in the treatment of endothelial dysfunction and a number of cardio-vascular diseases, though the development of highly-selective arginase II inhibitors is still a difficult task