DYNAMICS OF ACUTE CORONARY SYNDROME PATIENT MANAGEMENT IN NONIVASIVE PRIMARY VASCULAR CENTER (ACCORDING TO RECORD AND RECORD-2 REGISTERS)

Aim. To study changes in acute coronary syndrome (ACS) patient hospital management in nonivasive primary vascular center in 2007-2009. Material and methods. 188 (RECORD register data) and 180 (RECORD-2 register data) patients with ACS were admitted to the emergency cardiology department in November 2007 and November 2009, respectively. Results. Thrombolytic therapy was performed in 62 patients in 2009 whereas in 2007 no one patient received this therapy because of thrombolytic drugs absence. Only 39.4% of patients were treated with unfractionated heparin in 2007. In 2009 50% of patients received unfractionated heparin, 12.5% of patients – enoxaparin and 7.4% - fondaparinux. 2.7% of ACS patients were transferred to the regional vascular center in 2007 and 3.9% -  in 2009. Conclusion. Creation of the primary vascular center led to improvement of ACS patient hospital management, and move it closer to modern guidelines. However hospital lethality did not changed (3.3% and 3.7% in 2009 and 2007, respectively)

Giant Magnetoresistance Oscillations Induced by Microwave Radiation and a Zero-Resistance State in a 2D Electron System with a Moderate Mobility

The effect of a microwave field in the frequency range from 54 to 140 $\mathrm{GHz}$ on the magnetotransport in a GaAs quantum well with AlAs/GaAs superlattice barriers and with an electron mobility no higher than $10^6$ $\mathrm{cm^2/Vs}$ is investigated. In the given two-dimensional system under the effect of microwave radiation, giant resistance oscillations are observed with their positions in magnetic field being determined by the ratio of the radiation frequency to the cyclotron frequency. Earlier, such oscillations had only been observed in GaAs/AlGaAs heterostructures with much higher mobilities. When the samples under study are irradiated with a 140-$\mathrm{GHz}$ microwave field, the resistance corresponding to the main oscillation minimum, which occurs near the cyclotron resonance, appears to be close to zero. The results of the study suggest that a mobility value lower than $10^6$ $\mathrm{cm^2/Vs}$ does not prevent the formation of zero-resistance states in magnetic field in a two-dimensional system under the effect of microwave radiation.Comment: 4 pages, 2 figur

ABOUT NITRIDE COATING OF ARTIFICIAL ARTICLES FROM COPPER–NICKEL ALLOY

Изучено ионно-плазменное напыление промышленного сплава Cu–Ni–Zn композиции (типа МНЦ15-20) комбинированной обработкой нитридами титана и циркония. Для оценки микротвердости покрытия использовалась методика, предусматривающая обязательное проникновение алмазного индентора сквозь нитридный слой. Показано, что микротвердость покрытия более чем в 6 раз превышает эти показатели для материала основы. Рассмотренные режимы напыления обеспечивают формирование нитридных слоев, полностью имитирующих эффект золочения.Ion-plasma spraying that was made by titanium and zirconium nitrides complex treatment of an industrial alloy of a Cu-Ni-Zn alloy was studied. To evaluate the microhardness of the coating we used a technique that required the compulsory penetration of the diamond indenter through the nitride layer. It is shown the microhardness of the coating is six times higher than these values for the base material. The reviewed modes of spraying provide the nitride layers formation that imitates completely the gold plating

Symmetry Influence on the Rotation of Molecules in Crystals

© 2017 American Chemical Society. It was shown that rotational mobility of molecules in crystals is affected by the symmetry of their surroundings. A hypothesis was proposed for the discovered correlation. Three cases are possible for the location of the molecules with respect to the crystallographic symmetry elements: I - the location in a general position; II - the location in special positions without symmetry disordering; III - the location in special positions with symmetry disordering. According to the experimental data, the rotation barrier heights at the location of the molecules in cases I and III are lower than in case II. This fact is explained by the amplitude and p hase shifts of the rotational energy profiles of two parts of the molecule in case I and by increasing the number of minima on the rotation barrier profile at disordering the molecules by symmetry in case III. The way is proposed for lowering the rotational barrier of molecules in crystals

Treatment of the amyotrophic lateral sclerosis using of genetically modified umbilical cord blood mononuclear cells in the preclinical studies

Development of the fundamental and clinical «regenerative medicine» is based on the progress of gene, stem cell and gene-cell biotechnologies. However, the reliable preclinical investigations on animal models and more over clinical trials stay far away from the available nowadays gene and cell constructions. Neuroscience is one of the fast growing fields of knowledge in biology and medicine. Pioneer experiments in neuroscience promises breakthrough in the innovative methods for treatment of neurodegenerative diseases in near future. This review addresses strategies for gene-cell therapy of neurodegenerative diseases by the example of amyotrophic lateral sclerosis. Precisely gene modification of mononuclear fraction of umbilical cord blood cells (UCBC) by dual cassette plasmid vectors is observed. Based on our own results of transplantation of genetically modified UCBC overexpressing recombinant neural cell adhesion molecule L1, vascular endothelial growth factor, fibroblast growth factor 2, and glial derived neurotrophic factor in different combinations we provide the experimental data for usefulness of transplantation of gene modified UCBC for treating neurodegenerative diseases. In the review we discuss the efficacy of gene modification of UCBC not only for secretion of recombinant proteins, but in increasing of transplanted cells survivability, their migration possibilities and capability to differentiate in endothelial, microglial and macroglial cell types

2,4-Diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides, their structure and S-silyl dithiophosphonic derivatives

© 2016 Taylor & Francis Group, LLC.Novel 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfideswere prepared by the reactions of tetraphosphorus decasulfide with butylphenyl ether or 3-brominephenyl-1-isoamyl ether in 1,2-dichlorobenzene. Their structures were established by X-ray single crystal diffraction. Chiral S-trimethylsilyl dithiophosphonates were prepared by the reactions of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with trimethyl silyl ethers of monoterpenols. Unsaturated S-trimethylsilyl dithiophosphonates were synthesized by the reactions of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with O-trimethylsilyl ethers of geraniol, nerol, and (R,S)-linalool. S-Esters of dithiophosphonic acids, which possessed antimicrobial activity, were prepared by the reactions of chiral S-trimethylsilyl dithiophosphonateswith orthoformiates, acetals and thioacetals

Over-expression of Oct4 and Sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo

Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis. © 2014 Elsevier Inc. All rights reserved

Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:To evaluate the treatment of spinal cord injury with glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector (AdV-GDNF group) in comparison with treatment performed using human umbilical cord blood mononuclear cells (UCB-MCs)-transduced with an adenoviral vector carrying the GDNF gene (UCB-MCs+AdV-GDNF group) in rat.Setting:Kazan, Russian Federation.Methods:We examined the efficacy of AdV-GDNF and UCB-MCs+AdV-GDNF therapy by conducting behavioral tests on the animals and morphometric studies on the spinal cord, performing immunofluorescence analyses on glial cells, investigating the survival and migration potential of UCB-MCs, and evaluating the expression of the recombinant GDNF gene.Results:At the 30th postoperative day, equal positive locomotor recovery was observed after both direct and cell-based GDNF therapy. However, after UCB-MCs-mediated GDNF therapy, the area of preserved tissue and the number of spared myelinated fibers were higher than those measured after direct GDNF gene therapy. Moreover, we observed distinct changes in the populations of glial cells; expression patterns of the specific markers for astrocytes (GFAP, S100B and AQP4), oligodendrocytes (PDGFαR and Cx47) and Schwann cells (P0) differed in various areas of the spinal cord of rats treated with AdV-GDNF and UCB-MCs+AdV-GDNF.Conclusion:The differences detected in the AdV-GDNF and UCB-MCs+AdV-GDNF groups could be partially explained by the action of UCB-MCs. We discuss the insufficiency and the advantages of these two methods of GDNF gene delivery into the spinal cord after traumatic injury.Spinal Cord advance online publication, 29 September 2015; doi:10.1038/sc.2015.161