4 research outputs found
ΠΡΠ»ΡΡΠΈΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΡΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Π±Π΅Π· Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ°Π³Π°
The purpose of the study was to evaluate the method of combined modality treatment of patients with metastases of melanoma without detectable primary tumor. Metastases of melanoma of unknown primary origin were diagnosed in 21 (6 %) of 346 patients. Of them, 16 patients had metastases in lymph nodes, 4 in soft tissues and 1 in bones. To choose the treatment method, the general health status of the patient, location of metastases and the extent of tumor involvement were considered. The combined modality treatment of patients with metastases of melanoma with unknown primary site had allowed 10 patients to survive more than 3 years with no evidence of disease progression. The complete response was achieved in 10 (47,6 %) patients, partial response in 8 (38,1 %) patients and disease progression in 3 (14,3 %) patients. The 5-year survival rate was 46,1 Β± 12,0 % and the median follow-up time was 52,0 Β± 11,2 months.Π¦Π΅Π»Ρ β ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Π±Π΅Π· Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ°Π³Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π»ΡΡΠ΅Π²ΠΎΠΉ ΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»: ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Ρ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Π±Π΅Π· ΠΠΠ Π±ΡΠ»ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Ρ Ρ 21 (6 %) ΠΈΠ· 346 Π±ΠΎΠ»ΡΠ½ΡΡ
. Π Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ·Π»Ρ β Ρ 16, Π² ΠΌΡΠ³ΠΊΠΈΠ΅ ΡΠΊΠ°Π½ΠΈ β Ρ 4, Π² ΠΊΠΎΡΡΠΈ β Ρ 1 Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ. ΠΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠΈΡΡΠ²Π°Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅Π΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ, Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ², ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°, ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΠ°Ρ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ°Π³Π°. ΠΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Π±Π΅Π· ΠΠΠ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ 10 Π±ΠΎΠ»ΡΠ½ΡΠΌ ΠΏΡΠΎΠΆΠΈΡΡ Π±ΠΎΠ»Π΅Π΅ 3 Π»Π΅Ρ Π±Π΅Π· ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠΈ ΡΡΠΎΠΌ ΠΏΠΎΠ»Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡ Ρ 10 (47,6 %), ΡΠ°ΡΡΠΈΡ- Π½ΡΠΉ β Ρ 8 (38,1 %), ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ Ρ 3 (14,3 %). ΠΡΡΠΈΠ»Π΅ΡΠ½ΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 46,1 Β± 12,0 %, ΠΌΠ΅Π΄ΠΈΠ°Π½Π° Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ β52,0 Β± 11,2 ΠΌΠ΅Ρ
Π‘ΠΈΡΡΠ΅ΠΌΠ½Π°Ρ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ Ρ ΡΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠΌ ΡΠΎΡΠΎΠ»ΠΎΠ½ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ ΡΠ΅Π³ΠΈΠΎΠ½Π°ΡΠ½ΡΠΌΠΈ ΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ
Β The results of photodynamic therapy (PDT) in 76 patients with tumors of different sites and with regional or distant metastases are represented. Sixty three patients were under combined or multimodal therapy, 13 patients had systemic PDT as monotherapy. The technique of PDT was as follows: the solution of photosensitizer photolon was administered intravenously at dose of 0.8β1.4 mg/ kg body weight. Laser blood irradiation was performed simultaneously (wavelength of 662 nm, output power of 20 mW, irradiation time of 50 min). Stabilization of the disease defined as the absence of new tumor foci was observed in 55% of treated patients: among them in 47% of patients with disseminated melanoma during 6β10 months after treatment, in 65% patients with breast cancer β for 3β6 years after treatment, and also in 100% of patients with cancer of other sites (colorectal, pancreatic, cervical, ovarian, lung and stomach cancer, retroperitoneal neuroblastoma) β for 10β12 months after treatment. According to ultrasound data the shrinkage of most of metastases up to its complete disappearance was observed. The authors consider that effects of systemic PDT are due to decrease of circulating tumor cells in blood and also due to beneficial impact of this modal of treatment on immune status of cancer patient. Intravenous PDT was shown to improve treatment results and quality of life in patients with metastases of malignant tumors. The approved technique is of considerable interest and requires further investigation of its efficiency including its combination with methods of combined and multimodal treatment.Β ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (Π€ΠΠ’) Ρ 76 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΏΡΡ
ΠΎΠ»ΡΠΌΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΡΠ΅Π³ΠΈΠΎΠ½Π°ΡΠ½ΡΡ
ΠΈΠ»ΠΈ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ². Π¨Π΅ΡΡΡΠ΄Π΅ΡΡΡ ΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΠ»ΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, 13 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ ΡΠΈΡΡΠ΅ΠΌΠ½Π°Ρ Π€ΠΠ’ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΊΠ°ΠΊ ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π€ΠΠ’ Π·Π°ΠΊΠ»ΡΡΠ°Π»Π°ΡΡ Π² ΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΌ: Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠ°ΡΡΠ²ΠΎΡ ΡΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠ° ΡΠΎΡΠΎΠ»ΠΎΠ½ Π² Π΄ΠΎΠ·Π΅ 0,8β1,4 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. ΠΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π»Π°Π·Π΅ΡΠ½ΠΎΠ΅ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ (Π΄Π»ΠΈΠ½Π° Π²ΠΎΠ»Π½Ρ 662 Π½ΠΌ, ΠΌΠΎΡΠ½ΠΎΡΡΡ Π»Π°Π·Π΅ΡΠ° Π½Π° Π²ΡΡ
ΠΎΠ΄Π΅ 20 ΠΌΠΡ, Π²ΡΠ΅ΠΌΡ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ 50 ΠΌΠΈΠ½). Π‘ΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π² Π²ΠΈΠ΄Π΅ ΠΎΡΡΡΡΡΡΠ²ΠΈΡ Π½ΠΎΠ²ΡΡ
ΠΎΡΠ°Π³ΠΎΠ² ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Ρ 55% ΠΏΡΠΎΠ»Π΅ΡΠ΅Π½Π½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²: Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ 47% Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠΎΠΉ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 6β10 ΠΌΠ΅Ρ. ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ, Ρ 65% Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ β Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 3β6 Π»Π΅Ρ ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ 100% Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ Π΄ΡΡΠ³ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ (ΡΠ°ΠΊ ΠΏΡΡΠΌΠΎΠΉ ΠΈ ΠΎΠ±ΠΎΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΊΠΈΡΠΊΠΈ, ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ, ΡΠΈΡΠ½ΠΈΠΊΠΎΠ², Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΈ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π½Π΅ΠΉΡΠΎΠ±Π»Π°ΡΡΠΎΠΌΠ° Π·Π°Π±ΡΡΡΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π°) β Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 10β12 ΠΌΠ΅Ρ. ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ Π£ΠΠ, ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΠΎΠ² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΠ°ΡΡΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ°Π³ΠΎΠ² Π²ΠΏΠ»ΠΎΡΡ Π΄ΠΎ ΠΈΡ
ΠΏΠΎΠ»Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ΅Π·Π½ΠΎΠ²Π΅Π½ΠΈΡ. ΠΠ²ΡΠΎΡΡ ΡΡΠΈΡΠ°ΡΡ, ΡΡΠΎ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΡΡΠ΅ΠΊΡΠΎΠ² ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ Π€ΠΠ’ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ Π·Π° ΡΡΠ΅Ρ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΡ
Π² ΠΊΡΠΎΠ²ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π²ΠΈΠ΄Π° Π»Π΅ΡΠ΅Π½ΠΈΡ Π½Π° ΠΈΠΌΠΌΡΠ½Π½ΡΠΉ ΡΡΠ°ΡΡΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎΠΉ Π€ΠΠ’ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ»ΡΡΡΠΈΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠΏΡΠΎΠ±ΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ, ΡΡΠΎ ΡΡΠ΅Π±ΡΠ΅Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅, Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ.
MULTIDISCIPLINARY APPROACH TO THE TREATMENT OF PATIENTS WITH METASTASES OF MELANOMA WITHOUT DETECTABLE PRIMARY TUMOR
The purpose of the study was to evaluate the method of combined modality treatment of patients with metastases of melanoma without detectable primary tumor. Metastases of melanoma of unknown primary origin were diagnosed in 21 (6 %) of 346 patients. Of them, 16 patients had metastases in lymph nodes, 4 in soft tissues and 1 in bones. To choose the treatment method, the general health status of the patient, location of metastases and the extent of tumor involvement were considered. The combined modality treatment of patients with metastases of melanoma with unknown primary site had allowed 10 patients to survive more than 3 years with no evidence of disease progression. The complete response was achieved in 10 (47,6 %) patients, partial response in 8 (38,1 %) patients and disease progression in 3 (14,3 %) patients. The 5-year survival rate was 46,1 Β± 12,0 % and the median follow-up time was 52,0 Β± 11,2 months
Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases
Β The results of photodynamic therapy (PDT) in 76 patients with tumors of different sites and with regional or distant metastases are represented. Sixty three patients were under combined or multimodal therapy, 13 patients had systemic PDT as monotherapy. The technique of PDT was as follows: the solution of photosensitizer photolon was administered intravenously at dose of 0.8β1.4 mg/ kg body weight. Laser blood irradiation was performed simultaneously (wavelength of 662 nm, output power of 20 mW, irradiation time of 50 min). Stabilization of the disease defined as the absence of new tumor foci was observed in 55% of treated patients: among them in 47% of patients with disseminated melanoma during 6β10 months after treatment, in 65% patients with breast cancer β for 3β6 years after treatment, and also in 100% of patients with cancer of other sites (colorectal, pancreatic, cervical, ovarian, lung and stomach cancer, retroperitoneal neuroblastoma) β for 10β12 months after treatment. According to ultrasound data the shrinkage of most of metastases up to its complete disappearance was observed. The authors consider that effects of systemic PDT are due to decrease of circulating tumor cells in blood and also due to beneficial impact of this modal of treatment on immune status of cancer patient. Intravenous PDT was shown to improve treatment results and quality of life in patients with metastases of malignant tumors. The approved technique is of considerable interest and requires further investigation of its efficiency including its combination with methods of combined and multimodal treatment.Β </p