Dissipation control in cavity QED with oscillating mode structures

We demonstrate how a time-dependent dissipative environment may be used as a tool for controlling the quantum state of a two-level atom. In our model system the frequency and coupling strength associated with microscopic reservoir modes are modulated, while the principal features of the reservoir structure remain fixed in time. Physically, this may be achieved by containing a static atom-cavity system inside an oscillating external bath. We show that it is possible to dynamically decouple the atom from its environment, despite the fact that the two remain resonant at all times. This can lead to Markovian dynamics, even for a strong atom-bath coupling, as the atomic decay becomes inhibited into all but a few channels; the reservoir occupation spectrum consequently acquires a sideband structure, with peaks separated by the frequency of the environmental modulation. The reduction in the rate of spontaneous emission using this approach can be significantly greater than could be achieved with an oscillatory atom-bath detuning using the same parameters

Robust creation of arbitrary-sized Dicke states using a single laser pulse

We propose a novel technique for the creation of maximally entangled symmetric Dicke states in an ion trap using adiabatic passage, which requires only a pair of chirped pulses from a single laser and is applicable to any number of ions and excitations. By utilising a particular factorisation of the Hilbert space for multi-level ladders we show that the problem can be reduced to `bow-tie' configuration energy-level crossings. This technique is naturally robust against fluctuations in the laser intensity and the chirp rate. Even when realistic heating rates are considered, we estimate that the overall fidelity should remain high (e.g. 98% for a ten-ion Dicke state), which represents a significant improvement over traditional approaches.Comment: 5 pages, 4 figures. Minor changes. Journal Ref Adde

Scalable quantum search using trapped ions

We propose a scalable implementation of Grover's quantum search algorithm in a trapped-ion quantum information processor. The system is initialized in an entangled Dicke state by using simple adiabatic techniques. The inversion-about-average and the oracle operators take the form of single off-resonant laser pulses, addressing, respectively, all and half of the ions in the trap. This is made possible by utilizing the physical symmetrie of the trapped-ion linear crystal. The physical realization of the algorithm represents a dramatic simplification: each logical iteration (oracle and inversion about average) requires only two physical interaction steps, in contrast to the large number of concatenated gates required by previous approaches. This does not only facilitate the implementation, but also increases the overall fidelity of the algorithm.Comment: 6 pages, 2 figure

Decoherence-free preparation of Dicke states of trapped ions by collective stimulated Raman adiabatic passage

We propose a simple technique for the generation of arbitrary-sized Dicke states in a chain of trapped ions. The method uses global addressing of the entire chain by two pairs of delayed but partially overlapping laser pulses to engineer a collective adiabatic passage along a multi-ion dark state. Our technique, which is a many-particle generalization of stimulated Raman adiabatic passage (STIRAP), is decoherence-free with respect to spontaneous emission and robust against moderate fluctuations in the experimental parameters. Furthermore, because the process is very rapid, the effects of heating are almost negligible under realistic experimental conditions. We predict that the overall fidelity of synthesis of a Dicke state involving ten ions sharing two excitations should approach 98% with currently achievable experimental parameters.Comment: 14 pages, 8 figure

Control of atomic decay rates via manipulation of reservoir mode frequencies

We analyse the problem of a two-level atom interacting with a time-dependent dissipative environment modelled by a bath of reservoir modes. In the model of this paper the principal features of the reservoir structure remain constant in time, but the microscopic structure does not. In the context of an atom in a leaky cavity this corresponds to a fixed cavity and a time-dependent external bath. In this situation we show that by chirping the reservoir modes sufficiently fast it is possible to inhibit, or dramatically enhance the decay of the atomic system, even though the gross reservoir structure is fixed. Thus it is possible to extract energy from a cavity-atom system faster than the empty cavity rate. Similar, but less dramatic effects are possible for moderate chirps where partial trapping of atomic population is also possible.Comment: 12 pages, 9 figure

Robust control of quantized motional states of a chain of trapped ions by collective adiabatic passage

A simple technique for robust generation of vibrational Fock states in a chain of trapped ions is proposed. The method is fast and easy to implement, since only a single chirped laser pulse, simultaneously addressing all of the ions, is required. Furthermore, because the approach uses collective adiabatic passage, significant fluctuations in the intensity or frequency of the laser pulse can be tolerated, and the technique performs well even on the border of the Lamb-Dicke regime. We also demonstrate how this technique may be extended in order to create non-classical superposition states of the ions' collective motion and Greenberger-Horne-Zeilinger states of their internal states. Because only a single laser pulse is required, heating effects arising under realistic experimental conditions are negligibly small.Comment: 9 pages, 7 figures. Discussion of performance outside Lamb-Dicke regime added. Some refs adde

Passive experimental autoimmune encephalomyelitis in C57BL/6 with MOG: evidence of involvement of B cells

Experimental autoimmune encephalomyelitis (EAE) is the most relevant animal model to study demyelinating diseases such as multiple sclerosis. EAE can be induced by active (active EAE) or passive (at-EAE) transfer of activated T cells in several species and strains of rodents. However, histological features of at-EAE model in C57BL/6 are poorly described. The aim of this study was to characterize the neuroinflammatory and neurodegenerative responses of at-EAE in C57BL/6 mice by histological techniques and compare them with that observed in the active EAE model. To develop the at-EAE, splenocytes from active EAE female mice were harvested and cultured in presence of MOG 35-55 and IL-12, and then injected intraperitoneally in recipient female C57BL6/J mice. In both models, the development of EAE was similar except for starting before the onset of symptoms and presenting a higher EAE cumulative score in the at-EAE model. Spinal cord histological examination revealed an increased glial activation as well as more extensive demyelinating areas in the at-EAE than in the active EAE model. Although inflammatory infiltrates composed by macrophages and T lymphocytes were found in the spinal cord and brain of both models, B lymphocytes were significantly increased in the at-EAE model. The co-localization of these B cells with IgG and their predominant distribution in areas of demyelination would suggest that IgG-secreting B cells are involved in the neurodegenerative processes associated with at-EAE

Additivity and non-additivity of multipartite entanglement measures

We study the additivity property of three multipartite entanglement measures, i.e. the geometric measure of entanglement (GM), the relative entropy of entanglement and the logarithmic global robustness. First, we show the additivity of GM of multipartite states with real and non-negative entries in the computational basis. Many states of experimental and theoretical interests have this property, e.g. Bell diagonal states, maximally correlated generalized Bell diagonal states, generalized Dicke states, the Smolin state, and the generalization of D\"{u}r's multipartite bound entangled states. We also prove the additivity of other two measures for some of these examples. Second, we show the non-additivity of GM of all antisymmetric states of three or more parties, and provide a unified explanation of the non-additivity of the three measures of the antisymmetric projector states. In particular, we derive analytical formulae of the three measures of one copy and two copies of the antisymmetric projector states respectively. Third, we show, with a statistical approach, that almost all multipartite pure states with sufficiently large number of parties are nearly maximally entangled with respect to GM and relative entropy of entanglement. However, their GM is not strong additive; what's more surprising, for generic pure states with real entries in the computational basis, GM of one copy and two copies, respectively, are almost equal. Hence, more states may be suitable for universal quantum computation, if measurements can be performed on two copies of the resource states. We also show that almost all multipartite pure states cannot be produced reversibly with the combination multipartite GHZ states under asymptotic LOCC, unless relative entropy of entanglement is non-additive for generic multipartite pure states.Comment: 45 pages, 4 figures. Proposition 23 and Theorem 24 are revised by correcting a minor error from Eq. (A.2), (A.3) and (A.4) in the published version. The abstract, introduction, and summary are also revised. All other conclusions are unchange

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.

Tuberculosis (TB) is responsible for enormous global morbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use for more than 40 years. Owing to widespread resistance to these therapies, new drugs are desperately needed to control the TB disease burden. Herein, we describe the rapid synthesis of analogues of the sansanmycin uridylpeptide natural products that represent promising new TB drug leads. The compounds exhibit potent and selective inhibition of Mycobacterium tuberculosis, the etiological agent of TB, both in vitro and intracellularly. The natural product analogues were also shown to be nanomolar inhibitors of Mtb phospho-MurNAc-pentapeptide translocase, the enzyme responsible for the synthesis of lipid I in mycobacteria. This work lays the foundation for the development of uridylpeptide natural product analogues as new TB drug candidates that operate through the inhibition of peptidoglycan biosynthesis

Cerebrospinal Fluid Dendritic Cells Infiltrate the Brain Parenchyma and Target the Cervical Lymph Nodes under Neuroinflammatory Conditions

BACKGROUND: In many neuroinflammatory diseases, dendritic cells (DCs) accumulate in several compartments of the central nervous system (CNS), including the cerebrospinal fluid (CSF). Myeloid DCs invading the inflamed CNS are thus thought to play a major role in the initiation and perpetuation of CNS-targeted autoimmune responses. We previously reported that, in normal rats, DCs injected intra-CSF migrated outside the CNS and reached the B-cell zone of cervical lymph nodes. However, there is yet no information on the migratory behavior of CSF-circulating DCs under neuroinflammatory conditions. METHODOLOGY/PRINCIPAL FINDINGS: To address this issue, we performed in vivo transfer experiments in rats suffering from experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. EAE or control rats were injected intra-CSF with bone marrow-derived myeloid DCs labeled with the fluorescent marker carboxyfluorescein diacetate succinimidyl ester (CFSE). In parallel experiments, fluorescent microspheres were injected intra-CSF to EAE rats in order to track endogenous antigen-presenting cells (APCs). Animals were then sacrificed on day 1 or 8 post-injection and their brain and peripheral lymph nodes were assessed for the presence of microspheres(+) APCs or CFSE(+) DCs by immunohistology and/or FACS analysis. Data showed that in EAE rats, DCs injected intra-CSF substantially infiltrated several compartments of the inflamed CNS, including the periventricular demyelinating lesions. We also found that in EAE rats, as compared to controls, a larger number of intra-CSF injected DCs reached the cervical lymph nodes. This migratory behavior was accompanied by an accentuation of EAE clinical signs and an increased systemic antibody response against myelin oligodendrocyte glycoprotein, a major immunogenic myelin antigen. CONCLUSIONS/SIGNIFICANCE: Altogether, these results indicate that CSF-circulating DCs are able to both survey the inflamed brain and to reach the cervical lymph nodes. In EAE and maybe multiple sclerosis, CSF-circulating DCs may thus support the immune responses that develop within and outside the inflamed CNS