Production of scalar KKˉK\bar K molecules in ϕ\phi radiative decays

The potentialities of the production of the scalar $K\bar K$ molecules in the $\phi$ radiative decays are considered beyond the narrow resonance width approximation. It is shown that $BR(\phi\rightarrow\gamma f_0(a_0)\rightarrow\gamma\pi\pi(\pi\eta))\approx (1\div 2)\times 10^{-5}\ ,\BR(\phi\rightarrow\gamma (f_0+a_0)\rightarrow\gamma K^+K^-)\alt 10^{-6}$and$BR(\phi\rightarrow\gamma (f_0+a_0) \to \gamma K^0\bar K^0)\alt 10^{-8}$. The mass spectra in the$\pi\pi\ ,\ \pi\eta\ ,\ K^+K^-\ ,\ K^0\bar K^0$channels are calculated. The imaginary part of the amplitude$\phi\rightarrow\gamma f_0(a_0)$is calculated analytically. It is obtained the phase of the scalar resonance production amplitude that causes the interference patterns in the reaction$e^+e^-\rightarrow\gamma \pi^+\pi^-$in the$\phi$ meson mass region.Comment: 19 pages, revtex, 4 eps files of figure

Search for the scalar a0a_0 and f0f_0 mesons in the reactions e+e−→γπ0π0(η)e^+e^-\to\gamma\pi^0\pi^0(\eta)

It is shown that the reactions $e^+e^-\to\gamma\pi^0\pi^0(\eta)$ give a good chance for observing scalar $a_0$ and $f_0$ mesons. In the photon energy region less then 100 MeV the vector meson contributions $e^+e^-\to V^0\to\pi^0 V'^0\to\gamma\pi^0\pi^0(\eta)$ are negligible in comparison with the scalar mesons $e^+e^-\to\phi\to\gamma f_0(a_0)\to\gamma\pi^0\pi^0(\eta)$ for $BR(\phi\to\gamma f_0(a_0)\to\gamma\pi^0\pi^0(\eta))$ greater than $5\cdot10^{-6}(10^{-5})$. Using two-channel treatment of the $\pi\pi$ scattering the predictions for $BR(\phi\to\gamma (f_0+\sigma)\to\gamma\pi\pi)$ are derived. The four quark model, the model of $K\bar K$ molecule and the$s\bar s$ model of scalar $f_0$ and $a_0$ mesons are discussed.Comment: 31 pages, 10 ps files of figures, minor numerical changes, Appendix corrected, to be published in Phys.Rev.

Association between food addiction and time perspective during COVID-19 isolation

Purpose: The concept of time perspective (TP) implies that a mental focus on past, present, or future affect a person makes decisions and take action. Inability to plan their life for a sufficiently long time perspective due to the COVID-19 pandemic appeared to have a pronounced impact on a human’s lifestyle influencing their thoughts, feelings, and behaviors, including eating behavior. This study tested two hypotheses: (a) that during COVID-19 isolation, the incidence rate of food addiction is increased, and (b) people with present TP are more likely exhibited signs of food addiction (FA). Methods: The final study sample included 949 people, mean age 21.8 ± 7.8 years (range: 17–71 years, women: 78.3%). Each participant indicated their personal data and completed Yale Food Addiction Scale and the Zimbardo Time Perspective Inventory. Results: There was an increased incidence rate of FA (OR = 1.678, 95% CI = 1.324, 2.148, p = 0.000) during COVID-19 isolation. Individuals with balanced, future, and past positive TP were less likely to exhibit symptoms of FA. Persons with past negative, and present hedonistic TP were more likely to exhibit signs of FA. Conclusion: There was an increased incidence rate of FA during COVID-19 isolation. Persons with shortened time horizon are more likely to exhibit symptoms of FA. Level of evidence: Level V, cross-sectional descriptive study. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG

Analogue peptides for the immunotherapy of human acute myeloid leukemia

Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies

New iterative methods for linear inequalities

New iterative methods for solving systems of linear inequalities are presented. Each step in these methods consists of finding the orthogonal projection of the current point onto a hyperplane corresponding to a surrogate constraint which is constructed through a positive combination of a group of violated constraints. Both sequential and parallel implementations are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45240/1/10957_2004_Article_BF00939954.pd

Strategies to Target Tumor Immunosuppression

The tumor microenvironment is currently in the spotlight of cancer immunology research as a key factor impacting tumor development and progression. While antigen-specific immune responses play a crucial role in tumor rejection, the tumor hampers these immune responses by creating an immunosuppressive microenvironment. Recently, major progress has been achieved in the field of cancer immunotherapy, and several groundbreaking clinical trials demonstrated the potency of such therapeutic interventions in patients. Yet, the responses greatly vary among individuals. This calls for the rational design of more efficacious cancer immunotherapeutic interventions that take into consideration the “immune signature” of the tumor. Multimodality treatment regimens that aim to enhance intratumoral homing and activation of antigen-specific immune effector cells, while simultaneously targeting tumor immunosuppression, are pivotal for potent antitumor immunity