Assessment of environmental and economic efficiency of iron ore breaking technology using emulsion explosives

Methodology for calculating parameters of drilling and blasting operations for stoping works in mines of Kryvorozhskiy basin and PJSC «Zaporizhskiy iron-ore plant» has been improved with the help of established coefficient of relative capacity for the Ukrainit-PM-2B explosive. A new technology of stoping operations for ore breaking by square-chamber methods at deposit thickness more than 5 m is proposed which assumes usage of emulsion explosives and downward drilling of production hole rings in the direction of underlying drilling horizons. Ecological and economical effectiveness of the proposed ore breaking technology implemented in the extraction chambers was estimated. Regularities of harmful substances hazard index changing were established depending on distance to the emission point when trotyl-contained and emulsion explosives are used. Implementation of the proposed technology allows decreasing prime-cost of 1 ton of ore by 15 % per one extraction unit

Optical echo in photonic crystals

The dynamics of photonic wavepacket in the effective oscillator potential is studied. The oscillator potential is constructed on a base of one dimensional photonic crystal with a period of unit cell adiabatically varied in space. The structure has a locally equidistant discrete spectrum. This leads to an echo effect, i.e. the periodical reconstruction of the packet shape. The effect can be observed in a nonlinear response of the system. Numerical estimations for porous-silicon based structures are presented for femtosecond Ti:Sapphire laser pump.Comment: 4 page

CHANGING SCHOOL-BASED ANXIETY DURING PHYSICAL EDUCATION, TAKING THE INDIVIDUAL TYPOLOGICAL APPROACH INTO ACCOUNT

Purpose of the study: The purpose of the study is to identify changes in school-based anxiety in children aged 12 – 13 during their physical education using a special Program for the individual typological approach implementation. Methodology: Two groups had been formed: reference and experimental (25 people each); three methods were used (Method for studying individual typological peculiarities of middle-school children by A. Belov, Method of Kondash's anxiety scale (1973), and Method of identifying general physical education of students); diagnostic testing of physical fitness was conducted (long jump from the spot; lifting the body in 30 sec. (press); push-up (girls); pulling up on the crossbar (boys); running 30 meters, shuttle running 3x10; bending forward from a sitting position). Main Findings: The results of the study have been statistically processed with Excel 2000 and STATISTICA 8.0, using the Student's t-test for dependent and independent samples. The M average has been found; the differences have been considered significant at p < 0.05. Applications of this study: The Program for the individual typological approach implementation has been compiled with an emphasis on reducing school-based anxiety in children aged 12 – 13; its features, objectives, indicators, criteria, content, and forms of implementation have been substantiated; a set of general physical exercises has been developed for each type of temperament, which includes the exercises for some groups of muscles of the upper shoulder girdle, back muscles, abdomen, and hips. Novelty/Originality of this study: The significant improvement in the physical fitness of students from the experimental group compared to the reference one identified during the term proves the efficiency of the implemented physical education program, taking into account the individual typological approach to the personality of adolescents with an emphasis on reducing their school-based anxiety. The results of the study have allowed formulating recommendations for improving the approaches to conducting physical education classes

Borrmann Effect in Photonic Crystals: Nonlinear Optical Consequences

Nonlinear-optical manifestations of the Borrmann effect that are consequences of the spectral dependence of the spatial distributions of the electromagnetic field in a structure are observed in one-dimensional photonic crystals. The spectrum of the light self-focusing effect corresponding to the propagation-matrix calculations has been measured near the edge of the photonic gap.Comment: 4 pages, 3 figures, published in russian at Pis'ma v Zhurnal Eksperimental'noi i Teoreticheskoi Fiziki, 2008, Vol. 87, No. 8, pp. 461-46

Standard definition of a clinical case of mumps and diagnostic effectiveness of the test systems used in the modern period

Introduction. Registration of regular epidemic outbreaks of mumps infection among young people, difficulties in the clinical diagnosis of the disease, the presence of specific clinical manifestations in adults with a severe course of infection make it necessary the improvement of the quality of diagnosis of the disease. The aim of the work is to develop a standard definition of a clinical case of mumps and to conduct a comparative assessment of the effectiveness of the diagnostic test systems used for mumps diagnostics based on the determination of their sensitivity and specificity. Materials and methods. To develop a standard definition of a clinical case of mumps based on ten combined clinical and laboratory parameters, a mathematical model was built using the logistic regression method. The study included 84 patients with mumps infection (main group) and 66 patients with non-epidemic sialoadenitis (comparison group). For a comparative evaluation of the diagnostic systems VectoParotitis-IgM, VectoParotitis-IgG, ELISA-Mumps-IgM, ELISA-Mumps-IgG, Anti-Mumps Virus ELISA-IgM, and Anti-Mumps Virus ELISA-IgG, a blood serum samples from patients (n = 41) with a diagnosis mumps? were tested in dynamics to assess their sensitivity, specificity, and diagnostic effectiveness. Results. The clinical symptom dry mouth increased the chance of diagnosing mumps by 13.7 times, the presence of bilateral lesions of the salivary glands by 6.5 times, the increase in the level of diastase in the urine by 3.2 times. The coefficient of determination R2 was 61.1; the sensitivity was 93% and the specificity 67%; p 0.001. Diagnostic effectiveness of Anti-Mumps Virus ELISA-IgG test system was 84.4%, ELISA-Mumps-IgG 87.2%, and "VectoParotitis-IgG" 88.5%. Conclusions. Based on the combination of following clinical symptoms observed simultaneously in patient, of the general weakness, dry mouth, bilateral lesions of the salivary glands, an increase in the level of diastase in the urine, it is possible to establish a clinical diagnosis of mumps with a probability of 81%. The highest diagnostic effectiveness of domestically manufactured test systems for quantitation of IgG antibodies to mumps virus in sick people has been demonstrted

IL-4 and its polymorphism (<i>IL4</i>-589C/T) in cervical neoplasia

The transition of cervical neoplasia (CIN) to cervical cancer occurs with the active participation of IL-4, for which both pro- and antitumor effects have been shown with tumors of various localizations. The expression of cytokines is regulated at the transcriptional level in the promoter region of the gene. It has been shown that the genotype IL4 (589C/T) (rs2243250) is associated with the development of gastric and breast cancer. The contribution of IL-4 genotypic variations to the development of CIN has not yet been studied. The aim of the study was to assess the risk of developing cervical neoplasia by the presence polymorphism of IL4 (589C/T) and the level of IL-4. The object of the study was circulating neutrophils, serum and genomic DNA of 36 patients with CIN and 20 women without dysplasia (comparison group). Using ELISA, the level of IL-4 was determined in neutrophil lysate and serum. Phagocytic activity and adhesive ability (CD11b) of neutrophils were assessed. Allele-specific real-time PCR using Taq-Man probes was used to analyze of the IL4 589C/T (rs2243250). Statistical processing was carried out using Statistica 13 and Jamovi 1.6.5.0. As a result of the study, it was found that the level of IL-4 in serum and circulating neutrophils in patients with CIN is significantly higher than in the comparison group. The -589C* allele of the IL4 gene and the TT genotype are more common in the group with CIN (55.5%) than in the control (25%). At the same time, a direct relationship was established between the presence of polymorphism and increased adhesive ability and with indicators of the phagocytic number of circulating neutrophils. Analysis of the incidence of IL4 C589T by the «case-control» method showed that the chances of CIN formation in carriers of the -589C allele and the TT genotype were 3.75 (95% CI: 1.013 - 13.880, Chi-square = 4.161, p = 0.042). The -589C* allele and TT IL4 genotype, neutrophil and serum IL-4 levels are associated with HPV infection. Using a binary logistic regression model, we demonstrated the possibility of using IL-4 levels in circulating neutrophils and IL-4 gene polymorphism (589C/T) for the differential diagnosis of patients with CIN (χ2 = 15.6, p = 0.001). Significant significance for their combination was assessed by ROC-curve analysis (IL-4 in neutrophils; IL4 (-589С*), 75% probability. Thus, the IL4 (589C/T) is associated with the adhesive and phagocytic activity of circulating neutrophils. In HPV-infected patients, IL4 gene polymorphism (589C/T) can serve as a marker for early detection and prognosis of CIN

Angiogenic potential of circulating peripheral blood neutrophils in kidney cancer

The role of neutrophils in kidney cancer is currently being studied. Their role in carcinogenesis is ambiguous. As one of the most abundant blood leukocytes, neutrophils play an important role in cancer progression through multiple mechanisms, including promotion of angiogenesis, immunosuppression, and cancer metastasis. Neutrophils synthesize and release pro-angiogenic factors that are able to directly or indirectly stimulate the growth and migration of endothelial cells, which in turn causes the formation of new blood vessels from pre-existing ones. The production of various factors by neutrophils, including proangiogenic ones, is mediated by the expression of the genes of these molecules. Functional heterogeneity is characterized by differences in neutrophil gene expression patterns. The aim of this study was to evaluate the angiogenic potential of circulating neutrophils in kidney cancer. The object of the study were blood neutrophils of patients with verified clear cell kidney cancer at stage I (T1N0M0G1, n = 28, median age 60), stage II (T2N0M0G2, n = 15, median age 61) and stage III (T3N0M0G2, n = 15, median age 63) before surgery. The control group consisted of apparently healthy donors (n = 15, median age 54). Serum levels of IL-8 and VEGF-A were assessed by enzyme immunoassay. Expression of the CXCL8 and VEGF-A genes in circulating neutrophils was determined by reverse transcription quantitative PCR. As a result of our study, an increase in the level of IL-8 and VEGF-A in the blood serum of patients with kidney cancer in all studied groups compared with the control group was revealed. We observed a direct correlation between serum levels of IL-8 and VEGF-A in patients with kidney cancer (r = 0.429; p = 0.016), which confirms the relationship of these angiogenic factors. A significant increase in CXCL8 gene expression by circulating neutrophils was found in patients on II (2.91, Q0.25-Q0.75: (1.296-4.99), p = 0.02) and III (1.93, Q0.25-Q0.75: (0.755-11.36, p = 0.014) stages of kidney cancer compared with the control group (1.50, Q0.25-Q0.75: (0.80-4.05)). However, VEGF-A gene expression by circulating neutrophils did not differ from those in the control group. Blood neutrophils in kidney cancer exercise their angiogenic potential through the production of IL-8

Phenotype of circulating neutrophils at different stages of cervical neoplasia

At the present time, there is no common point of view to the role of circulating neutrophils (NP) in emergence and development of neoplasia. It is suggested that due to high functional plasticity, the neutrophils may exhibit both pro- and antitumor activity. In order to study the NP phenotype at different stages of cervical neoplasia (CN), we have evaluated their absolute and relative amounts, myeloperoxidase activity, spontaneous and induced NST-test markers, and the level of intracellular cationic proteins. Spontaneous production of elastase and active forms of matrix metalloproteinases, the levels of IL-2, IL-8, IL-18, IFNy, G-CSF were determined in the NP cell lysates and in blood serum. The formation of extracellular traps (NET) was evaluated using 1-day cultures of Saccharomyces cerevisiae as an inducer. We examined 31 patients with cervical intraepithelial neoplasia (CIN) and 21 primary patients with cervical cancer (CC, Ia stage according to FIGO scale), as well as 25 practically healthy women. We revealed increased spontaneous and inducible oxygen-dependent cytolytic and phagocytic activity and spontaneous production of NET if compared to normal values, along with decreased absolute NP numbers in patients with CIN, thus suggesting the antitumor activity of NP. The levels of “pro-tumor” cytokines (MMP-9, IL-2 and G-CSF) become increased over normal levels as early as at the CIN stage, both for the neutrophils and blood plasma. High levels of regulatory IFNy and neutrophil-priming IL-8 in blood plasma do not presume any use of exogenous NP-activating factors at the stage of cervical dysplasia. At the initial stage of cervical cancer, the absolute NP amounts are significantly increased compared to normal counts. However, despite increased spontaneous oxygen-dependent cytolytic activity, the NPs have a significantly reduced activity of phagocytosis and sharply increased spontaneous production of NET, thus, generally, being characteristic to the “pro-tumorous” NP phenotype. IL-2 levels are elevated, and MMP-9 values are still increased in NP and blood plasma of patients with CC (stage Ia). Hence, the obtained results suggest some changes of NP phenotype to a pro-tumorous pattern during transition from intraepithelial dysplasia to cervical cancer. These results allowed us to design an algorithm for examining women with suspected cervical cancer, including IL-2 measurement in blood serum, and MMP-9 amounts in the NP lysates

The significance of assessing risk factors for premature ovarian failure in women with low ovarian reserve and history of abortion

The aim of the study - to study the impact of risk factors for POI in the treatment of infertility in women with low ovarian reserve and a history of abortion.Цель исследования - изучить влияние факторов риска ПНЯ при лечении бесплодия у женщин с низким овариальным резервом и прерыванием беременности по желанию в анамнезе

Intraosseous infusion of medicines with autogenous thrombocytose gel in the therapy of chronic parodontal diseases

63 patients with parodontal diseases were divided into two groups. We used standard flap surgery in the first group (32 patients, 50,8%). Complex therapy of the second group (31 patients, 49,2%) were suppelmented with intraosseous infusion of natrium hypochlorite 0,03%. The results of our investigations allow us to speak about enhancement of efficiency in the complex treatment of parodontal disease