5 research outputs found
Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives
Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were con rmed by IR, UV, 1H-NMR, 13C-NMR, Mass spectral and analytical data. The compounds were investigated for their antimicrobial activity alongside gentamicin clinical standard. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active compound was 1H-benzo[d]imidazol-2-yl)methanamine, 10a
Microwave-assisted synthesis and antibacterial propensity of N0-s-benzylidene-2-propylquinoline- 4-carbohydrazide and N0-((s-1H-pyrrol- 2-yl)methylene)-2-propylquinoline- 4-carbohydrazide motifs
Microwave-assisted approach was utilized as green approach to access a series of 2-pro
pylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes
in highly encouraging yields. It involved four steps reaction which was initiated with ring opening
reaction of isatin in a basified environment and subsequent cross-coupling with pentan-2-one to
produce compound 7. Esterification of 7 in acid medium led to the formation of compound 8 which
was reacted with hydrazine hydrate to access 9 which upon microwave-assisted condensed with aromatic
and heteroaromatic aldehydes furnished the targeted compounds 10a-j. The structures of 10aj
were confirmed by physico-chemical, elemental analyses and spectroscopic characterization which
include UV, FT-IR, 1H and 13C NMR as well as DEPT-135. The targeted compounds 10a-j, alongside
with gentamicin clinical standard, were investigated for their antibacterial efficacies using agar
diffusion method. 2-Propyl-N0-(pyridine-3-ylmethylene) quinoline-4-carbohydrazide 10j emerged a
Functionalization of La0.33Ca0.67MnO3 with biologically active small ligand at room temperature
Wereportthestructural,morphological andopticalactivities of a paramagneticmanganite(La0.33Ca0.67MnO3) synthesized
at 900�C. A simple method of formation of complex was employed. A complex was formed between a pre-prepared
manganite dissolved in HCl and reacted with an organic ligand (ethyl 4-nitrobenzoate). The optical and antimicrobial
properties of a complex were determined. The Ultraviolet-visible and Fourier-transforminfra-red spectroscopy wereused
inmonitoringoptical activitiesof theresultingproduct. Itwasobserved toabsorb in thevisible region (205nmand256nm).
The peaks observed from the infra-red spectra indicated that the reaction occurred at the nitroso end of the ethyl 4-
nitrobenzoate. The bacterial inhibitorypropertyoftheLCMO-ethyl 4-nitrobenzoatewasdetermined against Pseudomonas
aeruginosa, Candida albican, Aspergillus niger and Staphylococcus auerus. It was observed to inhibit the growth of all the
microbes with zone of inhibitions of 60mm, 56mm, 45mm and 32mm, for Pseudomonas aeruginosa, Candida albican,
Aspergillus niger and Staphylococcus auerus, respectivel