Measuring linguistic complexity in long-term L2 speakers of English and L1 attriters of German

Linguistic complexity is neither easily defined nor measured. The challenge in finding reliable ways to measure linguistic complexity is even more pronounced when the variation of contexts in which complexity is measured is taken into account. This paper therefore aims at finding measures for assessing syntactic and lexical complexity that are sensitive and non-overlapping even in a less frequently studied context: spontaneous speech of L1 attriters and highly proficient L2 English speakers. To evaluate operationalizations of syntactic and lexical complexity, several previously proposed measures are applied to a corpus of spontaneous speech and a principal component analysis is conducted. The results show which of the measures group together as underlying variables of syntactic and lexical complexity and how this can inform future operationalizations of complexity

Fracture behavior of rammed earth in historic buildings

Rammed earth is the construction system of many heritage structures and buildings in different regions of the planet, some of which are seismically active areas. For this reason, these historic buildings can sustain structural damage or have already been subjected to stresses that have led to high levels of cracking in the rammed earth walls. Therefore, knowledge of the fracture behavior of this material is essential to assess the actual state of structural safety and the remaining mechanical capacity. The number of studies on the fracture behavior of rammed earth is limited, and even fewer studies have considered lime as a stabilizer and used traditional materials. This study measured the density, ultrasonic pulse velocity, fracture energy and tensile strength of prismatic specimens with two different soil:lime dosages and found relationships between the different parameters analyzed and the dosages used. Finally, it was verified that the fracture behavior of rammed earth can be assumed to be similar to that of mass concrete from a qualitative standpoint. For this reason, rammed earth could be considered as a quasi-brittle material that follows Hillerborg's discrete crack model. © 2021 Elsevier Lt

Comparison of Bioluminescent Substrates in Natural Infection Models of Neglected Parasitic Diseases

The application of in vivo bioluminescent imaging in infectious disease research has significantly increased over the past years. The detection of transgenic parasites expressing wildtype firefly luciferase is however hampered by a relatively low and heterogeneous tissue penetrating capacity of emitted light. Solutions are sought by using codon-optimized red-shifted luciferases that yield higher expression levels and produce relatively more red or near-infrared light, or by using modified bioluminescent substrates with enhanced cell permeability and improved luminogenic or pharmacokinetic properties. In this study, the in vitro and in vivo efficacy of two modified bioluminescent substrates, CycLuc1 and AkaLumine-HCl, were compared with that of D-luciferin as a gold standard. Comparisons were made in experimental and insect-transmitted animal models of leishmaniasis (caused by intracellular Leishmania species) and African trypanosomiasis (caused by extracellular Trypanosoma species), using parasite strains expressing the red-shifted firefly luciferase PpyRE9. Although the luminogenic properties of AkaLumine-HCl and D-luciferin for in vitro parasite detection were comparable at equal substrate concentrations, AkaLumine-HCl proved to be unsuitable for in vivo infection follow-up due to high background signals in the liver. CycLuc1 presented a higher in vitro luminescence compared to the other substrates and proved to be highly efficacious in vivo, even at a 20-fold lower dose than D-luciferin. This efficacy was consistent across infections with the herein included intracellular and extracellular parasitic organisms. It can be concluded that CycLuc1 is an excellent and broadly applicable alternative for D-luciferin, requiring significantly lower doses for in vivo bioluminescent imaging in rodent models of leishmaniasis and African trypanosomiasis

Percentage of nonoverlapping corrected data

The present study proposes a modification in one of the most frequently applied effect size procedures in single-case data analysis the percent of nonoverlapping data. In contrast to other techniques, the calculus and interpretation of this procedure is straightforward and it can be easily complemented by visual inspection of the graphed data. Although the percent of nonoverlapping data has been found to perform reasonably well in N = 1 data, the magnitude of effect estimates it yields can be distorted by trend and autocorrelation. Therefore, the data correction procedure focuses on removing the baseline trend from data prior to estimating the change produced in the behavior due to intervention. A simulation study is carried out in order to compare the original and the modified procedures in several experimental conditions. The results suggest that the new proposal is unaffected by trend and autocorrelation and can be used in case of unstable baselines and sequentially related measurements