304 research outputs found
Euclidean Gibbs states of interacting quantum anharmonic oscillators
A rigorous description of the equilibrium thermodynamic properties of an
infinite system of interacting -dimensional quantum anharmonic oscillators
is given. The oscillators are indexed by the elements of a countable set
, possibly irregular; the anharmonic potentials
vary from site to site. The description is based on the representation of the
Gibbs states in terms of path measures -- the so called Euclidean Gibbs
measures. It is proven that: (a) the set of such measures
is non-void and compact; (b) every obeys an
exponential integrability estimate, the same for the whole set
; (c) every has a
Lebowitz-Presutti type support; (d) is a singleton at
high temperatures. In the case of attractive interaction and we prove
that at low temperatures. The uniqueness of Gibbs
measures due to quantum effects and at a nonzero external field are also proven
in this case. Thereby, a qualitative theory of phase transitions and quantum
effects, which interprets most important experimental data known for the
corresponding physical objects, is developed. The mathematical result of the
paper is a complete description of the set , which refines
and extends the results known for models of this type.Comment: 60 page
Vortical Patterns in the Wake of an Oscillating Airfoil
The vortical flow patterns in the wake of a NACA 0012 airfoil pitching at small amplitudes are studied in a low speed water channel. it is shown that a great deal of control can be exercised on the structure of the wake by the control of the frequency, amplitude and also the shape of the oscillation waveform. An important observation in this study has been the existence of an axial flow along the cores of the wake vortices. Estimates of the magnitude of the axial flow suggest a linear dependence on the oscillation frequency and amplitude
Full nonperturbative QCD simulations with 2+1 flavors of improved staggered quarks
Dramatic progress has been made over the last decade in the numerical study
of quantum chromodynamics (QCD) through the use of improved formulations of QCD
on the lattice (improved actions), the development of new algorithms and the
rapid increase in computing power available to lattice gauge theorists. In this
article we describe simulations of full QCD using the improved staggered quark
formalism, ``asqtad'' fermions. These simulations were carried out with two
degenerate flavors of light quarks (up and down) and with one heavier flavor,
the strange quark. Several light quark masses, down to about 3 times the
physical light quark mass, and six lattice spacings have been used. These
enable controlled continuum and chiral extrapolations of many low energy QCD
observables. We review the improved staggered formalism, emphasizing both
advantages and drawbacks. In particular, we review the procedure for removing
unwanted staggered species in the continuum limit. We then describe the asqtad
lattice ensembles created by the MILC Collaboration. All MILC lattice ensembles
are publicly available, and they have been used extensively by a number of
lattice gauge theory groups. We review physics results obtained with them, and
discuss the impact of these results on phenomenology. Topics include the heavy
quark potential, spectrum of light hadrons, quark masses, decay constant of
light and heavy-light pseudoscalar mesons, semileptonic form factors, nucleon
structure, scattering lengths and more. We conclude with a brief look at highly
promising future prospects.Comment: 157 pages; prepared for Reviews of Modern Physics. v2: some rewriting
throughout; references update
Brane-World Gravity
The observable universe could be a 1+3-surface (the "brane") embedded in a
1+3+\textit{d}-dimensional spacetime (the "bulk"), with Standard Model
particles and fields trapped on the brane while gravity is free to access the
bulk. At least one of the \textit{d} extra spatial dimensions could be very
large relative to the Planck scale, which lowers the fundamental gravity scale,
possibly even down to the electroweak ( TeV) level. This revolutionary
picture arises in the framework of recent developments in M theory. The
1+10-dimensional M theory encompasses the known 1+9-dimensional superstring
theories, and is widely considered to be a promising potential route to quantum
gravity. At low energies, gravity is localized at the brane and general
relativity is recovered, but at high energies gravity "leaks" into the bulk,
behaving in a truly higher-dimensional way. This introduces significant changes
to gravitational dynamics and perturbations, with interesting and potentially
testable implications for high-energy astrophysics, black holes, and cosmology.
Brane-world models offer a phenomenological way to test some of the novel
predictions and corrections to general relativity that are implied by M theory.
This review analyzes the geometry, dynamics and perturbations of simple
brane-world models for cosmology and astrophysics, mainly focusing on warped
5-dimensional brane-worlds based on the Randall--Sundrum models. We also cover
the simplest brane-world models in which 4-dimensional gravity on the brane is
modified at \emph{low} energies -- the 5-dimensional Dvali--Gabadadze--Porrati
models. Then we discuss co-dimension two branes in 6-dimensional models.Comment: A major update of Living Reviews in Relativity 7:7 (2004)
"Brane-World Gravity", 119 pages, 28 figures, the update contains new
material on RS perturbations, including full numerical solutions of
gravitational waves and scalar perturbations, on DGP models, and also on 6D
models. A published version in Living Reviews in Relativit
Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression:A marker of malignant potential?
Peer reviewedPublisher PD
Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer
<p>Abstract</p> <p>Background</p> <p>Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript.</p> <p>Methods</p> <p>We measured the expression and isoform usage of seven prostate cancer candidate genes in benign and malignant prostate by real-time PCR, and correlated these factors with cancer status and genotype at the GWAS risk variants.</p> <p>Results</p> <p>We determined that levels of <it>LMTK2 </it>transcripts in prostate adenocarcinomas were only 32% of those in benign tissues (p = 3.2 Ă 10<sup>-7</sup>), and that an independent effect of genotype at variant rs6465657 on <it>LMTK2 </it>expression in benign (n = 39) and malignant tissues (n = 21) was also evident (P = 0.002). We also identified that whilst <it>HNF1B(C) </it>and <it>MSMB2 </it>comprised the predominant isoforms in benign tissues (90% and 98% of total <it>HNF1B </it>or <it>MSMB </it>expression)<it>, HNF1B(B) and MSMB1 </it>were predominant in malignant tissue (95% and 96% of total <it>HNF1B </it>or <it>MSMB </it>expression; P = 1.7 Ă 10<sup>-7 </sup>and 4 Ă 10<sup>-4 </sup>respectively), indicating major shifts in isoform usage.</p> <p>Conclusions</p> <p>Our results indicate that the amount or nature of mRNA transcripts expressed from the <it>LMTK2</it>, <it>HNF1B </it>and <it>MSMB </it>candidate genes is altered in prostate cancer, and provides further evidence for a role for these genes in this disorder. The alterations in isoform usage we detect highlights the potential importance of alternative mRNA processing and moderation of mRNA stability as potentially important disease mechanisms.</p
DHX9 Helicase promotes R-loop formation in cells with impaired RNA splicing
Unresolved R-loops can represent a threat to genome stability. Here the authors reveal that DHX9 helicase can promote R-loop formation in the absence of splicing factors SFPQ and SF3B3
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