Development and characterization of a copper ion-selective optical sensor based on a novel calix[4]dicyano-diimidazole thin film

International audienceA novel optical sensor for sensitive and selective determination of copper ions in aqueous solution based on a novel calix[4]dicyano-diimidazole ionophore was prepared. The newly synthesized calix[4]dicyano-diimidazole exhibited obvious absorbance enhancement at 284 nm in the presence of copper ions. At pH 6.8, the measuring range of the optode membrane for Cu2+ ions was from 1.0 × 10−8 to 1.0 × 10−4 M with a detection limit of 7.0 × 10−9 M. Furthermore, the response time of the proposed optical device was within 10 min. With the optimum condition described, the optical sensor revealed good selectivity toward Cu2+ ions in comparison with common coexisting cations (Hg2+, Pb2+, Cd2+, Ni2+ and Zn2+). Finally, the reproducibility, regeneration, reversibility and repeatability of this optical sensor were discussed

Characterization of a sensitive and selective copper optode based on β-ketoimine modified calix[4]arene derivative.

International audienceIn this paper, an optical sensor was proposed for sensitive determination of copper (II) ions in aqueous solution. The sensing membrane was prepared by coating β-ketoimine calix[4]arene derivative as ionophore on a glass plate surface. Thin β-ketoimine calix[4]arene layer was characterized by contact angle measurements showing a good surface coverage. Besides, a smooth and homogeneous morphology of the calixarene membrane was examined by atomic force microscopy (AFM). The response of the optode is based on the decrease in the absorbance signal at 309 nm upon exposure to buffer solutions containing Cu2 + ions. At a pH 6.8, the proposed sensor displays a calibration response for copper over a wide concentration range of 1.0 × 10− 7 M to 1.0 × 10− 4 M with a detection limit of 2.0 × 10− 8 M and response time of 7–10 min. This optode exhibits good selectivity toward copper ions in comparison with common ions including Hg2 + and Ag+ ions. The copper sensing film can be regenerated using 0.01 M HNO3 solution. In addition to its high stability, repeatability and reproducibility, the sensor shows operational life time of 4 weeks

Detection of heavy metals by an optical fiber sensor with a sensitive cladding including a new chromogenic calix[4]arene molecule

International audienceIndustrial processes introduce up to a million different pollutants into the atmosphere and the aquatic ecosystem. Heavy metals are one group of these substances, although not all of them are considered harmful to humans. The molecule of calixarene is a macrocycle used effectively in the complexation of the heavy metal pollutants (nickel, copper(II)...). The goal of this work is to condition a new chromogenic calix[4]arene molecule to elaborate an optical fiber sensor able to detect this type of pollutant. The light power increases when the concentration of the ion increases. The optimum pH for heavy metal ion detection is found to be 5. The influence of the unclad length on the response sensor is studied and the optimum length is found to be around 3 cm. The limit of detection reached is of the order of 1 mu M, 10(-3) mu M and 10(-4) mu M for copper(II), cobalt(II) and cadmium(II) cations respectively

Real-life experience of quality of life, treatment satisfaction, and adherence in patients receiving oral anticoagulants for atrial fibrillation

Michaël Benzimra,1 Béatrix Bonnamour,1 Martin Duracinsky,2 Christophe Lalanne,2 Jean-Pierre Aubert,2,3 Olivier Chassany,2,3 Isabelle Aubin-Auger,2,3 Isabelle Mahé1,2 1Internal Medicine Department, Hôpital Louis Mourier, APHP, Colombes, France; 2Méthodologies et Société (REMES) EA 7334, Recherche Clinique Ville-hôpital, Université Paris Diderot, Sorbonne Paris Cité, Paris, France; 3General Medicine Deparment, Université Paris 7, Paris, France Introduction: Direct oral anticoagulants (DOACs) have shown noninferiority to vitamin K antagonists (VKA) in stroke prevention in patients with atrial fibrillation. DOAC treatment may be less demanding than VKA, improving quality of life. To date, there have been no studies of the real-life experience of outpatients receiving anticoagulation therapy for atrial fibrillation in France.Methods: An observational descriptive real-life epidemiological study used three validated questionnaires (EQ-5D, PACT-Q2, and MMAS-8 French Translation) to assess quality of life, treatment satisfaction, and adherence, respectively, in 200 patients managed on an outpatient basis for atrial fibrillation who were receiving anticoagulation therapy by VKA or DOAC for at least 3 months. Patients were distributed between four groups: primary VKA (P-VKA), switch from VKA to DOAC (S-DOAC), primary DOAC (P-DOAC), and switch from DOAC to VKA (S-VKA).Results: Two hundred patients responded to the questionnaires: 89, 50, 52, and 9 in the P-VKA, S-DOAC, P-DOAC and S-VKA groups, respectively. Only the first three groups were compared statistically, because of the small size of the S-VKA group. Quality of life and satisfaction were good in all three groups, with no significant difference in quality of life but significantly greater satisfaction with respect to the “convenience” and “satisfaction” dimensions for DOACs (S-DOAC and P-DOAC groups versus P-VKA group; p<0.001, for both dimensions). Adherence did not significantly differ between groups.Conclusion: The experience of patients under oral anticoagulation therapy for atrial fibrillation managed on an outpatient basis was good, with comparable quality of life under DOACs and VKA, and significantly greater satisfaction under DOACs, without impact on adherence. Taking account of patient preference in “shared decision-making” for the choice of type of anticoagulant could improve the patients’ experience of treatment. Keywords: atrial fibrillation, direct oral anticoagulants, vitamin K antagonists, satisfaction, adherence, quality of lif