The decomposition of level-1 irreducible highest weight modules with respect to the level-0 actions of the quantum affine algebra Uq′(sl^n)U'_q(\hat{sl}_n)

We decompose the level-1 irreducible highest weight modules of the quantum affine algebra $U_q(\hat{sl}_n)$ with respect to the level-0 $U'_q (\hat{sl}_n)$--action defined in q-alg/9702024. The decomposition is parameterized by the skew Young diagrams of the border strip type.Comment: 22 pages, AMSLaTe

On irreducibility of tensor products of evaluation modules for the quantum affine algebra

Every irreducible finite-dimensional representation of the quantized enveloping algebra U_q(gl_n) can be extended to the corresponding quantum affine algebra via the evaluation homomorphism. We give in explicit form the necessary and sufficient conditions for irreducibility of tensor products of such evaluation modules.Comment: 22 pages. Some references are adde

Awaking of ferromagnetism in GaMnN through control of Mn valence

Room temperature ferromagnetism of GaMnN thin films is awaked by a mild hydrogenation treatment of samples synthesized by molecular beam epitaxy. Local environment of Mn atoms is monitored by Mn-L2,3 near edge x-ray absorption fine structure (NEXAFS) technique. Doped Mn ions are present at substitutional sites of Ga both before and after the hydrogenation. No secondary phase can be detected. Major valency of Mn changes from +3 to +2 by the hydrogenation. The present result supports the model that the ferromagnetism occurs when Mn2+ and Mn3+ are coexistent and holes in the mid- gap Mn band mediate the magnetic coupling.Comment: 12 pages, 5 figure

Strain-Rate Effects on Microstructural Deformation in Irradiated 316 SS

A series of studies have been performed to investigate the post-irradiation deformation and failure behavior of 12% cold-worked 316 stainless steel following irradiation to variety of doses and temperatures in the outer rows of the experimental breeder reactor II (EBR-II). In the current phase of these studies, three sets of samples with different radiation induced microstructures have been characterized with transmission electron microscopy (TEM) following tensile testing to failure at a ‘fast’ strain-rate (1 x 10-3 s-1) and a ‘slow’ strain-rate (1 x 10-7 s-1). The samples were irradiated to doses between 9 and 41 dpa at temperatures between 383 and 443 degrees C. Tensile tests were conducted at a temperature of 430 degrees C and only regions outside of the necked region were examined. Over the parameters tested, strain-rate had a negligible effect on the deformation microstructure. In addition, there was no clear evidence of localized deformation behavior and the deformation appeared relatively homogeneous, characterized by unfaulting and incorporation of faulted dislocation loops into the general dislocation network structure. The influence of the defect microstructures and strain-rate on deformation behavior is discussed

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies

Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but recurrently targeted by somatic chromosomal translocations to IGH and non-IG loci in B-cell neoplasms, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. In addition, cases with genomic amplification of TERT locus were identified. Tumors bearing chromosomal aberrations involving TERT showed higher TERT transcriptional expression and increased telomerase activity. These data suggest that deregulation of TERT gene by chromosomal abnormalities leading to increased telomerase activity might contribute to B-cell lymphomagenesis

Several Distinct Polycomb Complexes Regulate and Co-Localize on the INK4a Tumor Suppressor Locus

Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene. Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 and BMI1. Each complex contains a single representative of the Pc and Psc families. In primary human fibroblasts, CBX7, CBX8, MEL18 and BMI1 are present at the INK4a locus and shRNA-mediated knockdown of any one of these components results in de-repression of INK4a and proliferative arrest. Sequential chromatin immunoprecipitation (ChIP) reveals that CBX7 and CBX8 bind simultaneously to the same region of chromatin and knockdown of one of the Pc or Psc proteins results in release of the other, suggesting that the binding of PRC1 complexes is interdependent. Our findings provide the first evidence that a single gene can be regulated by several distinct PRC1 complexes and raise important questions about their configuration and relative functions