Improving the Efficiency of Convergence of the Member States of the Eurasian Economic Union

The article is devoted to the formation, formation and development of the Eurasian Economic Union. As part of the study, a historical analysis of the formation of the Eurasian Economic Union, the main prerequisites for its origin, the stages of formation and the conditions of operation were carried out. In the work, based on the use of mathematical, statistical and comparative methods, an analysis was made of the economic indicators of the national member states of the Eurasian Economic Union, which resulted in the conclusion that the Russian Federation is the largest region that has 80% of the total potential of the Union. The paper discusses the basics of the formation of common markets for goods and services, which today are created in each field of activity of national economies. As a result of the analysis, factors that hinder the creation of common supranational systems and markets of national states were identified. The analysis made it possible to formulate proposals for further convergence of the types of economic activities of the national republics into a single supranational mechanism. At the end of the work conclusions are drawn from the results of the study

Анализ профиля экспрессии длинных некодирующих РНК у больных с идиопатическим и COVID-19-индуцированным легочным фиброзом

Introduction. Idiopathic pulmonary fibrosis (IPF) comprises an interstitial lung disease with unclear pathogenesis, rapid progression, and no effective treatment. Pulmonary fibrosis is reported to be one of the most severe complications induced by a new coronavirus infection COVID-19. The mechanisms triggering pulmonary fibrosis and leading to its rapid progression remain substantially unclear. Evidence suggests that immune and genetic factors contribute to the development of this disease. Among the latter, the role of long non-coding RNAs (dnRNAs) has been actively studied to date. Materials and methods. Considering the role of TP53TG1, LINC00342, H19, MALAT1, DNM3OS, and MEG3 dnRNAs as regulators of signaling pathways associated with fibroblast activation and epithelial-mesenchymal transition, the authors analyzed the expression level of selected dnRNAs in lung tissue and blood mononuclear cells of patients with IPF (N = 12), post-COVID-19 pulmonary fibrosis (N = 14), and in control group (N = 27). Results and discussion. Blood mononuclear cells in patients with IPF and post-COVID-19 PF revealed similar patterns of TP53TG1 and MALAT1 dnRNA expression. The level of relative expression of MALAT1 was significantly higher in patients with IPF (Fold Change=3.207, P = 0.0005) and with post-COVID-19 PF (Fold Change=9.854, P = 0.0003), while the relative expression level of TP53TG1 reduced in patients with IPF (Fold Change=0.4308, P = 0.0313) and with post-COVID-19 PF (Fold Change=0.1888, P = 0.0003 in blood mononuclear cells, Fold Change=0.1791, P = 0.0237 in lung tissue). Increased expression of DNM3OS in blood mononuclear cells (Fold Change=12.899, P = 0.0016) and lung tissue (Fold Change=9.527, P = 0.0001), LINC00342 (Fold Change=2.221, P = 0.0309) in blood mononuclear cells was revealed only in patients with IPF. Conclusion. Evaluation of the dnRNA expression profile of TP53TG1, LINC00342, MALAT1 and DNM3OS in blood mononuclei can be used as an informative and non-invasive biomarker in IPF and post COVID-19 PF.Введение. Идиопатический легочный фиброз (ИЛФ) является интерстициальным заболеванием легких с неясным патогенезом, быстропрогрессирующим и не имеющим эффективного лечения. Одним из самых грозных осложнений после перенесенной новой коронавирусной инфекции COVID-19 является легочный фиброз. Механизмы, которые запускают легочный фиброз и приводят к его быстрому прогрессированию, остаются в значительной степени неопределенными. Имеются данные о вкладе иммунных и генетических факторов в развитие данного заболевания. Среди последних на сегодня активно изучается роль длинных некодирующих РНК (днРНК). Материалы и методы. Учитывая роль днРНК TP53TG1, LINC00342, H19, MALAT1, DNM3OS и MEG3 как регуляторов сигнальных путей, связанных с активацией фибробластов и эпителиально-мезенхимального перехода, мы проанализировали уровень экспрессии выбранных днРНК в легочной ткани и мононуклеарных клетках крови больных с ИЛФ (N = 12), пост-COVID-19 легочным фиброзом (N = 14) и контрольной группе (N = 27). Результаты и обсуждение. Определены сходные паттерны экспрессии днРНК TP53TG1 и MALAT1 в мононуклеарах крови у больных с ИЛФ и пост-COVID-19 ЛФ. Уровень относительной экспрессии MALAT1 был значимо выше у больных: при ИЛФ (Fold Change = 3,207, P = 0,0005) и при пост-COVID-19 ЛФ (Fold Change = 9,854, P = 0,0003). В то время как относительный уровень экспрессии TP53TG1 был снижен: при ИЛФ (Fold Change = 0,4308, P = 0,0313) и при пост-COVID-19 ЛФ (Fold Change = 0,1888, P = 0,0003 в мононуклеарах крови, Fold Change = 0,1791, P = 0,0237 в легочной ткани). Повышение уровня экспрессии DNM3OS в мононуклеарах крови (Fold Change = 12,899, P = 0,0016) и легочной ткани (Fold Change = 9,527, P = 0,0001), LINC00342 (Fold Change = 2,221, P = 0,0309) в мононуклеарах крови было установлено только у больных ИЛФ. Заключение. Таким образом, оценка профиля экспрессии днРНК TP53TG1, LINC00342, MALAT1 и DNM3OS в мононуклеарах крови может быть использована в качестве информативного и неинвазивного биомаркера при ИЛФ и пост COVID-19 ЛФ

EXPORT POTENTIAL EVALUATION OF THE ELECTRIC POWER INDUSTRY IN THE RUSSIAN FEDERATION

Introduction. The article is devoted to the export potential analysis of the electric power industry in the Russian Federation during the convergence period of the electric power complex into the Common Electricity Market of the Eurasian Economic Union.Materials and methods. The authors review the main indicators of the electricity sectors of the Eurasian Economic Union State Members. As a result of the analysis, it is revealed that the Russian electric power industry is the most large-scale and diversified industry in comparison with other Union state members. It is substantiated that the electric power complex of the Russian Federation could be fully provided with Russian fuel and energy resources, which give additional stability and competitiveness. Results. The evaluation of the electric power industry export potential of the Russian Federation couldn’t be made without determining the electric energy competitiveness, in which, according to the authors, it is advisable to include indicators of specific reference fuel consumption, loss in grids and cost of electric energy, both on the territory of the Eurasian Economic Union State Members and in the overseas market. As a result of the competitiveness analysis, it was revealed that Russian electrical energy may have certain competitive advantages in the common market and in foreign electricity markets.Discussion and conclusions. The main conclusions about the research results are made by the authors

Sensorless method of controlling the position of the movable element of the electric machine of the reciprocating action of

The article describes a Sensorless method for determining the position of the movable element electrical machines reciprocating action. The method is implemented on the basis of the data voltages of the windings and the results of measurements of parameters of electrical machines reciprocating action

Stand for after repair tests of asynchronous motors with voltage up to 1000 V

This article deals with the issues of an objective assessment of the technical condition of asynchronous motors with voltage up to 1000 V. A stand is proposed for post-repair tests. Test stand allows you to conduct induction motor tests to form an objective conclusion about the technical condition and quality of the repair carried out automatically