Structure of human transthyretin complexed with bromophenols: a new mode of binding

The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. Both compounds bind to TTR with high affinity, in competition with the natural ligand thyroxine (

Rectification of displacement currents in an adiabatic electron pump

Rectification of ac displacement currents generated by periodic variation of two independent gate voltages of a quantum dot can lead to a dc voltage linear in the frequency. The presence of this rectified displacement current could account for the magnetic field symmetry observed in a recent measurement on an adiabatic quantum electron pump by Switkes et al. [Science 283, 1905 (1999)].Comment: 2 pages, RevTeX; 1 figur

Semiclassical theory of a quantum pump

In a quantum charge pump, the periodic variation of two parameters that affect the phase of the electronic wavefunction causes the flow of a direct current. The operating mechanism of a quantum pump is based on quantum interference, the phases of interfering amplitudes being modulated by the external parameters. In a ballistic quantum dot, there is a minimum time before which quantum interference can not occur: the Ehrenfest time. Here we calculate the current pumped through a ballistic quantum dot when the Ehrenfest time is comparable to the mean dwell time. Remarkably, we find that the pumped current has a component that is not suppressed if the Ehrenfest time is much larger than the mean dwell time.Comment: 14 pages, 8 figures. Revised version, minor change

Andreev reflection from non-centrosymmetric superconductors and Majorana bound state generation in half-metallic ferromagnets

We study Andreev reflection at an interface between a half metal and a superconductor with spin-orbit interaction. While the absence of minority carriers in the half metal makes singlet Andreev reflection impossible, the spin-orbit interaction gives rise to triplet Andreev reflection, i.e., the reflection of a majority electron into a majority hole or vice versa. As an application of our calculation, we consider a thin half metal film or wire laterally attached to a superconducting contact. If the half metal is disorder free, an excitation gap is opened that is proportional to the spin-orbit interaction strength in the superconductor. For electrons with energy below this gap a lateral half-metal--superconductor contact becomes a perfect triplet Andreev reflector. We show that the system supports localized Majorana end states in this limit.Comment: 14 pages, 3 figure

Nonequilibrium theory of Coulomb blockade in open quantum dots

We develop a non-equilibrium theory to describe weak Coulomb blockade effects in open quantum dots. Working within the bosonized description of electrons in the point contacts, we expose deficiencies in earlier applications of this method, and address them using a 1/N expansion in the inverse number of channels. At leading order this yields the self-consistent potential for the charging interaction. Coulomb blockade effects arise as quantum corrections to transport at the next order. Our approach unifies the phase functional and bosonization approaches to the problem, as well as providing a simple picture for the conductance corrections in terms of renormalization of the dot's elastic scattering matrix, which is obtained also by elementary perturbation theory. For the case of ideal contacts, a symmetry argument immediately allows us to conclude that interactions give no signature in the averaged conductance. Non-equilibrium applications to the pumped current in a quantum pump are worked out in detail.Comment: Published versio

Distributions of the Conductance and its Parametric Derivatives in Quantum Dots

Full distributions of conductance through quantum dots with single-mode leads are reported for both broken and unbroken time-reversal symmetry. Distributions are nongaussian and agree well with random matrix theory calculations that account for a finite dephasing time, $\tau_\phi$, once broadening due to finite temperature $T$ is also included. Full distributions of the derivatives of conductance with respect to gate voltage $P(dg/dV_g)$ are also investigated.Comment: 4 pages (REVTeX), 4 eps figure

Costs of compliance with EU regulations and competitiveness of the EU dairy sector

The introduction of cross-compliance mechanism in the European Union with its 2003 CAPreform might affect the costs of production and thus competitiveness of the EU. Little evidence is available to asses the costs of compliance with regulations and it implication for trade. In this study a farm level competitiveness analysis of the impacts of the Nitrate Directive and the Identification & registration Directive focuses on the dairy sector in Germany, France, Italy, Netherlands and UK (within EU), and the US and New Zealand (outside EU). The findings from this study are integrated into a trade analysis which assesses the impact of compliance costs on competitiveness of the various trading nations in global trade. Representative farm studies were used as a basis for the cost increase calculations. Best-estimates of compliance are used from the existing literature and expert judgements. The negative impact of these measures (for nitrates, and animal identification and registration) on EU imports and exports are less than 3 percent. If a smaller increase in compliance takes place, these already relatively small trade impacts will be further diminished. When the standards for nitrate pollution taken by the US and New Zealand are taken into account along with full compliance assumption in all countries analysed, this would only slightly improve the EU exports. The trade impacts obtained when no changes are assumed to happen in key competitor countries can thus be argued as providing the upper bound of the likely trade impacts

Andreev interference in adiabatic pumping

Within the scattering approach, we develop a model for adiabatic quantum pumping in hybrid normal/superconductor systems where several superconducting leads are present. This is exploited to study Andreev-interference effects on adiabatically pumped charge in a 3-arm beam splitter attached to one normal and two superconducting leads with different phases of the order parameters. We derive expressions for the pumped charge through the normal lead for different parameters for the scattering region, and elucidate the effects due to Andreev interference. In contrast to what happens for voltage-driven transport, Andreev interference does not yield in general a pumped current which is a symmetric function of the superconducting-phase difference.Comment: 4 pages, 1 figur

Interaction correction to the conductance of a ballistic conductor

In disordered metals, electron-electron interactions are the origin of a small correction to the conductivity, the "Altshuler-Aronov correction". Here we investigate the Altshuler-Aronov correction of a conductor in which the electron motion is ballistic and chaotic. We consider the case of a double quantum dot, which is the simplest example of a ballistic conductor in which the Altshuler-Aronov correction is nonzero. The fact that the electron motion is ballistic leads to an exponential suppression of the correction if the Ehrenfest time is larger than the mean dwell time or the inverse temperature.Comment: 4 pages, 2 figure

Conductance scaling at the band center of wide wires with pure non--diagonal disorder

Kubo formula is used to get the scaling behavior of the static conductance distribution of wide wires showing pure non-diagonal disorder. Following recent works that point to unusual phenomena in some circumstances, scaling at the band center of wires of odd widths has been numerically investigated. While the conductance mean shows a decrease that is only proportional to the inverse square root of the wire length, the median of the distribution exponentially decreases as a function of the square root of the length. Actually, the whole distribution decays as the inverse square root of the length except close to G=0 where the distribution accumulates the weight lost at larger conductances. It accurately follows the theoretical prediction once the free parameter is correctly fitted. Moreover, when the number of channels equals the wire length but contacts are kept finite, the conductance distribution is still described by the previous model. It is shown that the common origin of this behavior is a simple Gaussian statistics followed by the logarithm of the E=0 wavefunction weight ratio of a system showing chiral symmetry. A finite value of the two-dimensional conductance mean is obtained in the infinite size limit. Both conductance and the wavefunction statistics distributions are given in this limit. This results are consistent with the 'critical' character of the E=0 wavefunction predicted in the literature.Comment: 10 pages, 9 figures, RevTeX macr