Pearson’s correlation results between regional DTI changes and changes in clinical or bio-specimen changes.

<p>Pearson’s correlation results between regional DTI changes and changes in clinical or bio-specimen changes.</p

Demographics.

<p>Demographics.</p

Surface rendered brain maps of differences in regional DTI rates between PD patients and control subjects (FDR-corrected <i>P</i>_<i>FDR</i><0.05).

<p>Color scales indicate annual percentage change form baseline, separately for decline in fractional anisotropy (FA), increase in radial diffusivity (rD) and increase in axial diffusivity (aD).</p

Sample selection process.

<p>Sample selection process.</p

Flowchart of longitudinal DTI data processing.

<p>FA = fractional anisotropy; rD = radial diffusivity; aD = axial diffusivity; WM = white matter; GW = gray matter. MNI = Montreal Neurological Institute.</p

Baseline biomarker predictors of investigator diagnosis of cognitive impairment.

<p>Baseline biomarker predictors of investigator diagnosis of cognitive impairment.</p

Biomarker availability at baseline and longitudinally.

<p>Biomarker availability at baseline and longitudinally.</p

Baseline demographic and clinical characteristics.

<p>Baseline demographic and clinical characteristics.</p