3,919 research outputs found
Antiferromagnetically Driven Electronic Correlation in Iron Pnictides and Cuprates
The iron pnictides and the cuprates represent two families of materials,
where strong antiferromagnetic correlation drives three other distinct ordering
tendencies: (1) superconducting pairing, (2) Fermi surface distortion, and (3)
orbital current order. We propose that (1)-(3) and the antiferromagnetic
correlation are the hallmarks of a class of strongly correlated materials to
which the cuprates and pnictides belong. In this paper we present the results
of the functional renormalization group studies to support the above claim. In
addition, we show that as a function of the interlayer hopping parameter, the
double layer Hubbard model nicely interpolates between the cuprate and the iron
pnictide physics. Finally, as a check, we will present the renormalization
group study of a ladder version of the iron pnictide, and compare the results
to those of the two-dimensional model.Comment: 18 pages, 20 figures, revised version, one more figure added and
references update
Online Information Privacy: Measuring the Cost-Benefit Trade-Off
Concern over information privacy is widespread and rising. However, prior research is silent about the value of information privacy and the benefit of privacy protection. We conducted a conjoint analysis to explore individualsí trade-offs between the benefits and costs of providing personal information to Websites. We find that economic incentives (monetary reward and future convenience) do affect individualsí preferences over Websites with differing privacy policies. For instance, the disallowance of secondary use of personal information is worth between 49.78. Surprisingly, we find that cost-benefit trade-offs did not vary with personal characteristics including gender, contextual knowledge, individualism, and trust propensity
Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells.
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer. Herein, we investigated the roles of FUT1 and FUT2 in breast cancer. Silencing of FUT1 or FUT2 by shRNAs inhibited cell proliferation in vitro and tumorigenicity in mice. This was associated with diminished properties of cancer stem cell (CSC), including mammosphere formation and CSC marker both in vitro and in xenografts. Silencing of FUT2, but not FUT1, significantly changed the cuboidal morphology to dense clusters of small and round cells with reduced adhesion to polystyrene and extracellular matrix, including laminin, fibronectin and collagen. Silencing of FUT1 or FUT2 suppressed cell migration in wound healing assay, whereas FUT1 and FUT2 overexpression increased cell migration and invasion in vitro and metastasis of breast cancer in vivo. A decrease in mesenchymal like markers such as fibronectin, vimentin, and twist, along with increased epithelial like marker, E-cadherin, was observed upon FUT1/2 knockdown, while the opposite was noted by overexpression of FUT1 or FUT2. As expected, FUT1 or FUT2 knockdown reduced Globo H, whereas FUT1 or FUT2 overexpression showed contrary effects. Exogenous addition of Globo H-ceramide reversed the suppression of cell migration by FUT1 knockdown but not the inhibition of cell adhesion by FUT2 silencing, suggesting that at least part of the effects of FUT1/2 knockdown were mediated by Globo H. Our results imply that FUT1 and FUT2 play important roles in regulating growth, adhesion, migration and CSC properties of breast cancer, and may serve as therapeutic targets for breast cancer
Alignment of galaxy spins in the vicinity of voids
We provide limits on the alignment of galaxy orientations with the direction
to the void center for galaxies lying near the edges of voids. We locate
spherical voids in volume limited samples of galaxies from the Sloan Digital
Sky Survey using the HB inspired void finder and investigate the orientation of
(color selected) spiral galaxies that are nearly edge-on or face-on. In
contrast with previous literature, we find no statistical evidence for
departure from random orientations. Expressed in terms of the parameter c,
introduced by Lee & Pen to describe the strength of such an alignment, we find
that c<0.11(0.13) at 95% (99.7%) confidence limit within a context of a toy
model that assumes a perfectly spherical voids with sharp boundaries.Comment: 8 pages, 4 figures; v2 discussion expanded, references fixed, matches
version accepted by JCA
Nonuniform and coherent motion of superconducting vortices in the picometer-per-second regime
We investigated vortex dynamics in a single-crystal sample of type-II
superconductor NbSe using scanning tunneling microscopy at 4.2 K. The
decay of the magnetic field at a few nT/s in our superconducting magnet induced
the corresponding motion of vortices at a few pm/s. Starting with an initial
magnetic field of 0.5 T, we continued to observe motion of vortices within a
field of view of 400400 nm subject to decay of the magnetic field
over a week. Vortices moved collectively, and maintained triangular lattices
due to strong vortex-vortex interactions during the motion. However, we
observed two peculiar characteristics of vortex dynamics in this
superconductor. First, the speed and direction of the vortex lattice motion
were not uniform in time. Second, despite the non-uniform motion, we also found
that there exists an energetically favored configuration of the moving vortices
in the single-crystal sample of NbSe based on the overlaid trajectories
and their suppressed speeds. We model the system with weak bulk pinning, strong
bulk pinning, and edge barrier effects.Comment: 6 pages, 4 figures, Physical Review B (R) in press (2011
Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways
<p>Abstract</p> <p>Background</p> <p>Organotin compounds (OTCs) have been widely used as stabilizers in the production of plastic, agricultural pesticides, antifoulant plaints and wood preservation. The toxicity of triphenyltin (TPT) compounds was known for their embryotoxic, neurotoxic, genotoxic and immunotoxic effects in mammals. The carcinogenicity of TPT was not well understood and few studies had discussed the effects of OTCs on gap junctional intercellular communication (GJIC) of cells.</p> <p>Method</p> <p>In the present study, the effects of triphenyltin chloride (TPTC) on GJIC in WB-F344 rat liver epithelial cells were evaluated, using the scrape-loading dye transfer technique.</p> <p>Results</p> <p>TPTC inhibited GJIC after a 30-min exposure in a concentration- and time-dependent manner. Pre-incubation of cells with the protein kinase C (PKC) inhibitor did not modify the response, but the specific MEK 1 inhibitor PD98059 and PI3K inhibitor LY294002 decreased substantially the inhibition of GJIC by TPTC. After WB-F344 cells were exposed to TPTC, phosphorylation of Cx43 increased as seen in Western blot analysis.</p> <p>Conclusions</p> <p>These results show that TPTC inhibits GJIC in WB-F344 rat liver epithelial cells by altering the Cx43 protein expression through both MAPK and PI3-kinase pathways.</p
Logic-based Temporal Inferences in Natural Language
This paper concerns temporal inferences in natural language. The concept of time is crucially important because of its highly frequent use in utterances. However, time can appear in numerous forms, for example,
tense or time adverbials. It also may be implicitly specified by other events associating with some temporal conjunctions, such as when, before, after, etc. A logic-based approach is adopted to represent temporal information. Situations and time adverbials can be formally represented. Lexical knowledge about time and implications of situations also expressed in terms of logical clauses. Then we propose a temporal reasoning model. Various basic types of questions such as "When did event X happen?", "How long did event X last for?", "Did event X happen at time expression T?", etc. can be interpreted into temporal queries. Finally, we also use the same framework of logic to evaluate temporal queries, carry out computation and do the further deduction
Domain Walls and Phase Transitions in the Frustrated Two-Dimensional XY Model
We study and compare the critical properties of the two-dimensional (2D) XY
model in a transverse magnetic field with magnetic filling factors f=1/3 and
f=2/5. In addition to the spin waves, the low energy excitations of the system
consist of various domain walls between degenerate ground states. The lowest
energy domain wall has a similar structure for both f=1/3 and f=2/5 and its
properties dictate the nature of the phase transition. For f=2/5 these lowest
energy walls have a negative energy for binding to each other, giving rise to a
branching domain-wall structure and leading to a first order phase transition.
For f=1/3 this binding energy is positive, resulting in a linear critical
interface. In order to make a comparison to recent experiments, we investigate
the effect of small quenched bond disorder for f=2/5. A finite-size scaling
analysis of extensive Monte Carlo simulations strongly suggests that the
critical exponents of the phase transition for f=1/3, and for f=2/5 with
disorder, fall into the universality class of the two-dimensional Ising model.Comment: 5 pages, 3 eps figures, REVTEX, revised version with new figure
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