7,597 research outputs found
Dual task measures in older adults with and without cognitive impairment: Response to simultaneous cognitive-exercise training and minimal clinically important difference estimates
BACKGROUND: Responsiveness and minimal clinically important difference (MCID) are critical indices to understand whether observed improvement represents a meaningful improvement after intervention. Although simultaneous cognitive-exercise training (SCET; e.g., performing memory tasks while cycling) has been suggested to enhance the cognitive function of older adults, responsiveness and MCID have not been established. Hence, we aimed to estimate responsiveness and MCIDs of two dual task performance involving cognition and hand function in older adults with and without cognitive impairment and to compare the differences in responsiveness and MCIDs of the two dual task performance between older adults with and without cognitive impairment.
METHODS: A total of 106 older adults completed the Montreal Cognitive Assessment and two dual tasks before and after SCET. One dual task was a combination of Serial Sevens Test and Box and Block Test (BBT), and the other included frequency discrimination and BBT. We used effect size and standardized response mean to indicate responsiveness and used anchor- and distribution-based approaches to estimating MCID ranges. When conducting data analysis, all participants were classified into two cognitive groups, cognitively healthy (Montreal Cognitive Assessment ≥ 26) and cognitively impaired (Montreal Cognitive Assessment \u3c 26) groups, based on the scores of the Montreal Cognitive Assessment before SCET.
RESULTS: In the cognitively healthy group, Serial Seven Test performance when tasked with BBT and BBT performance when tasked with Serial Seven Test were responsive to SCET (effect size = 0.18-0.29; standardized response mean = 0.25-0.37). MCIDs of Serial Seven Test performance when tasked with BBT ranged 2.09-2.36, and MCIDs of BBT performance when tasked with Serial Seven Test ranged 3.77-5.85. In the cognitively impaired group, only frequency discrimination performance when tasked with BBT was responsive to SCET (effect size = 0.37; standardized response mean = 0.47). MCIDs of frequency discrimination performance when tasked with BBT ranged 1.47-2.18, and MCIDs of BBT performance when tasked with frequency discrimination ranged 1.13-7.62.
CONCLUSIONS: Current findings suggest that a change in Serial Seven Test performance when tasked with BBT between 2.09 and 2.36 corrected number (correct responses - incorrect responses) should be considered a meaningful change for older adults who are cognitively healthy, and a change in frequency discrimination performance when tasked with BBT between 1.47 and 2.18 corrected number (correct responses - incorrect responses) should be considered a meaningful change for older adults who are cognitively impaired. Clinical practitioners may use these established MCIDs of dual tasks involving cognition and hand function to interpret changes following SCET for older adults with and without cognitive impairment.
TRIAL REGISTRATION: NCT04689776, 30/12/2020
CaS: A key medium for C-O-S-Ca cycles in Earth
Oldhamite (CaS) is a rare mineral, which is only observed naturally in
enstatite meteorites.No occurrence of CaS has been documented from other groups
of meteorites and terrestrial samples. However, in experiments at 1.5 GPa/1510
K and 0.5 GPa/1320 K, when the lgfo2 is lower than -10.57 (FMQ-0.52), CaS was
produced in this study by a two-melt mechanism involving the reaction between
molten pyrrhotite-pentlandite-bearing orthopyroxenite and molten CaCO3. CaS can
be easily oxidized to form CaSO4 or hydrolyzed to produce calcium hydroxide,
which may explain why it has never been found in geological samples from Earth.
We speculate that part of the anhydrite and gypsum in black smokers along
mid-ocean ridges are related to the oxidation or hydrolysis of CaS in the
underlying mantle. CaS can be produced when the Siberian mantle plume intruded
into the lithosphere.Comment: The third versio
Observation of interlayer phonon modes in van der Waals heterostructures
We have investigated the vibrational properties of van der Waals
heterostructures of monolayer transition metal dichalcogenides (TMDs),
specifically MoS2/WSe2 and MoSe2/MoS2 heterobilayers as well as twisted MoS2
bilayers, by means of ultralow-frequency Raman spectroscopy. We discovered
Raman features (at 30 ~ 40 cm-1) that arise from the layer-breathing mode (LBM)
vibrations between the two incommensurate TMD monolayers in these structures.
The LBM Raman intensity correlates strongly with the suppression of
photoluminescence that arises from interlayer charge transfer. The LBM is
generated only in bilayer areas with direct layer-layer contact and atomically
clean interface. Its frequency also evolves systematically with the relative
orientation between of the two layers. Our research demonstrates that LBM can
serve as a sensitive probe to the interface environment and interlayer
interactions in van der Waals materials
Classification and Analysis of Regulatory Pathways Using Graph Property, Biochemical and Physicochemical Property, and Functional Property
Given a regulatory pathway system consisting of a set of proteins, can we predict which pathway class it belongs to? Such a problem is closely related to the biological function of the pathway in cells and hence is quite fundamental and essential in systems biology and proteomics. This is also an extremely difficult and challenging problem due to its complexity. To address this problem, a novel approach was developed that can be used to predict query pathways among the following six functional categories: (i) “Metabolism”, (ii) “Genetic Information Processing”, (iii) “Environmental Information Processing”, (iv) “Cellular Processes”, (v) “Organismal Systems”, and (vi) “Human Diseases”. The prediction method was established trough the following procedures: (i) according to the general form of pseudo amino acid composition (PseAAC), each of the pathways concerned is formulated as a 5570-D (dimensional) vector; (ii) each of components in the 5570-D vector was derived by a series of feature extractions from the pathway system according to its graphic property, biochemical and physicochemical property, as well as functional property; (iii) the minimum redundancy maximum relevance (mRMR) method was adopted to operate the prediction. A cross-validation by the jackknife test on a benchmark dataset consisting of 146 regulatory pathways indicated that an overall success rate of 78.8% was achieved by our method in identifying query pathways among the above six classes, indicating the outcome is quite promising and encouraging. To the best of our knowledge, the current study represents the first effort in attempting to identity the type of a pathway system or its biological function. It is anticipated that our report may stimulate a series of follow-up investigations in this new and challenging area
Anyon in External Electromagnetic Field: Hamiltonian and Lagrangian Formulations
We propose a simple model for a free relativistic particle of fractional spin
in 2+1 dimensions which satisfies all the necessary conditions. The canonical
quantization of the system leads to the description of one- particle states of
the Poincare group with arbitrary spin. Using the Hamil- tonian formulation
with the set of constraints, we introduce the electro- magnetic interaction of
a charged anyon and obtain the Lagrangian. The Casimir operator of the extended
algebra, which is the first-class constraint, is obtained and gives the
equation of motion of the anyon. In particular, from the latter it follows that
the gyromagnetic ratio for a charged anyon is two due to the parallelness of
spin and momentum of the particle in 2+1 dimensions. The canonical quantization
is also considered in this case.Comment: 9 pages, Latex, HU-SEFT R 1993-1
Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder
Classical Dynamics of Anyons and the Quantum Spectrum
In this paper we show that (a) all the known exact solutions of the problem
of N-anyons in oscillator potential precisely arise from the collective degrees
of freedom, (b) the system is pseudo-integrable ala Richens and Berry. We
conclude that the exact solutions are trivial thermodynamically as well as
dynamically.Comment: 19 pages, ReVTeX, IMSc/93/0
Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells
The sensitivity of non-small cell lung cancer (NSCLC) patients to EGFR tyrosine kinase inhibitors (TKIs) is strongly associated with activating EGFR mutations. Although not as sensitive as patients harboring these mutations, some patients with wild-type EGFR (wtEGFR) remain responsive to EGFR TKIs, suggesting that the existence of unexplored mechanisms renders most of wtEGFR-expressing cancer cells insensitive.Here, we show that acquired resistance of wtEGFR-expressing cancer cells to an EGFR TKI, gefitinib, is associated with elevated expression of breast cancer resistance protein (BCRP/ABCG2), which in turn leads to gefitinib efflux from cells. In addition, BCRP/ABCG2 expression correlates with poor response to gefitinib in both cancer cell lines and lung cancer patients with wtEGFR. Co-treatment with BCRP/ABCG2 inhibitors enhanced the anti-tumor activity of gefitinib.Thus, BCRP/ABCG2 expression may be a predictor for poor efficacy of gefitinib treatment, and targeting BCRP/ABCG2 may broaden the use of gefitinib in patients with wtEGFR
Perturbative Renormalizations of Anyon Quantum Mechanics
In bosonic end perturbative calculations for quantum mechanical anyon systems
a regularization and renormalization procedure, analogous to those used in
field theory, is necessary. I examine the reliability and the physical
interpretation of the most commonly used bosonic end regularization procedures.
I then use the regularization procedure with the most transparent physical
interpretation to derive some bosonic end perturbation theory results on anyon
spectra, including a 3-anyon ground state energy.Comment: 19 pages, Plain LaTex, MIT-CTP-232
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