Localization problem of the quasiperiodic system with the spin orbit interaction

We study one dimensional quasiperiodic system obtained from the tight-binding model on the square lattice in a uniform magnetic field with the spin orbit interaction. The phase diagram with respect to the Harper coupling and the Rashba coupling are proposed from a number of numerical studies including a multifractal analysis. There are four phases, I, II, III, and IV in this order from weak to strong Harper coupling. In the weak coupling phase I all the wave functions are extended, in the intermediate coupling phases II and III mobility edges exist, and accordingly both localized and extended wave functions exist, and in the strong Harper coupling phase IV all the wave functions are localized. Phase I and Phase IV are related by the duality, and phases II and III are related by the duality, as well. A localized wave function is related to an extended wave function by the duality, and vice versa. The boundary between phases II and III is the self-dual line on which all the wave functions are critical. In the present model the duality does not lead to pure spectra in contrast to the case of Harper equation.Comment: 10 pages, 11 figure

A Solution for Little Hierarchy Problem and b --> s gamma

We show that all the parameters which destabilize the weak scale can be taken around the weak scale in the MSSM without conflicting with the SM Higgs mass bound set by LEP experiment. The essential point is that if the lightest CP-even Higgs h in the MSSM has only a small coupling to Z boson, g_{ZZh}, LEP cannot generate the Higgs sufficiently. In the scenario, the SM Higgs mass bound constrains the mass of the heaviest CP-even Higgs H which has the SM like g_{ZZH} coupling. However, it is easier to make the heaviest Higgs heavy by the effect of off-diagonal elements of the mass matrix of the CP-even Higgs because the larger eigenvalue of 2 times 2 matrix becomes larger by introducing off-diagonal elements. Thus, the smaller stop masses can be consistent with the LEP constraints. Moreover, the two excesses observed at LEP Higgs search can naturally be explained as the signals of the MSSM Higgs h and H in this scenario. One of the most interesting results in the scenario is that all the Higgs in the MSSM have the weak scale masses. For example, the charged Higgs mass should be around 130 GeV. This looks inconsistent with the lower bound obtained by the b --> s gamma process as m_{H^\pm}>350GeV. However, we show that the amplitude induced by the charged Higgs can naturally be compensated by that of the chargino if we take the mass parameters by which the little hierarchy problem can be solved. The point is that the both amplitudes have the same order of magnitudes when all the fields in the both loops have the same order of masses.Comment: 14 pages, 5 figures, input parameter slightly changed, figures replaced, references correcte

Safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus and impaired renal function: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM)

STELLA-LONG TERM, a 3-year post-marketing surveillance study, evaluated the safety and effectiveness of the sodiumglucose cotransporter 2 inhibitor ipragliflozin in Japanese type 2 diabetes mellitus (T2DM) patients. Final results in the safety (n = 6697) and effectiveness populations (n = 5625) were analyzed by stratifying patients by baseline estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) into four subgroups (≥90, 60 to <90, 45 to <60, and <45) and two subgroups (≥60 and <60). Adverse drug reaction (ADR) incidence, and changes from baseline in glycosylated hemoglobin (HbA1c), bodyweight, and eGFR were assessed. The percentage of patients experiencing ADRs and serious ADRs was similar across most eGFR subgroups. Polyuria/pollakiuria was the most common ADR. Renal disorders and volume depletion ADRs were more frequent in the subgroups with more severe renal impairment at baseline than in those with an eGFR of 60 to <90 or ≥90 mL/min/1.73 m2. Bodyweight and HbA1c decreased in all subgroups, the latter by − 0.91% to − 0.40% (P <0.05 vs. baseline). eGFR increased in the 45 to <60 mL/min/1.73 m2 subgroup (+ 1.42 ± 8.77 mL/min/1.73 m2; P = 0.006). It decreased in the ≥90 and 60 to <90 mL/min/1.73 m2 subgroups (− 8.27 ± 13.73 and − 1.22 ± 10.34 mL/min/1.73 m2; P <0.001), but not to <60 mL/min/1.73 m2. In conclusion, there were no new or unexpected safety findings in Japanese patients treated with ipragliflozin for T2DM, and long-term sustained improvements in HbA1c and bodyweight were observed regardless of the presence of renal impairment

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

Various biological responses stimulated by insulin have been thought to be regulated by phosphatidylinosi-tol 3-kinase, including glucose transport, glycogen syn-thesis, and protein synthesis. However, the molecular link between phosphatidylinositol 3-kinase and these biological responses has been poorly understood. Re-cently, it has been shown that protein kinase B (PKB/c-Akt/ Rac) lies immediately downstream from phosphati-dylinositol 3-kinase. Here, we show that expression of a constitutively active form of PKB induced glucose up-take, glycogen synthesis, and protein synthesis in L6 myotubes downstream of phosphatidylinositol 3-kinase and independent of Ras and mitogen-activated protein kinase activation. Introduction of constitutively active PKB induced glucose uptake and protein synthesis but not glycogen synthesis in 3T3L-1 adipocytes, which lack expression of glycogen synthase kinase 3 different from L6 myotubes. Furthermore, we show that deactivation of glycogen synthase kinase 3 and activation of rapamy-cin- sensitive serine/threonine kinase by PKB in L6 myo-tubes might be involved in the enhancement of glycogen synthesis and protein synthesis, respectively. These re-sults suggest that PKB acts as a key enzyme linking phosphatidylinositol 3-kinase activation to multiple bi-ological functions of insulin through regulation of downstream kinases in skeletal muscle, a major target tissue of insulin

Higgs boson mass limits in perturbative unification theories

Motivated in part by recent demonstrations that electroweak unification into a simple group may occur at a low scale, we detail the requirements on the Higgs mass if the unification is to be perturbative. We do this for the Standard Model effective theory, minimal supersymmetry, and next-to-minimal supersymmetry with an additional singlet field. Within the Standard Model framework, we find that perturbative unification with sin2(thetaW)=1/4 occurs at Lambda=3.8 TeV and requires mh<460 GeV, whereas perturbative unification with sin2(thetaW)=3/8 requires mh<200 GeV. In supersymmetry, the presentation of the Higgs mass predictions can be significantly simplified, yet remain meaningful, by using a single supersymmetry breaking parameter Delta_S. We present Higgs mass limits in terms of Delta_S for the minimal supersymmetric model and the next-to-minimal supersymmetric model. We show that in next-to-minimal supersymmetry, the Higgs mass upper limit can be as large as 500 GeV even for moderate supersymmetry masses if the perturbative unification scale is low (e.g., Lambda=10 TeV).Comment: 20 pages, latex, 6 figures, references adde

Precision Gauge Unification from Extra Yukawa Couplings

We investigate the impact of extra vector-like GUT multiplets on the predicted value of the strong coupling. We find in particular that Yukawa couplings between such extra multiplets and the MSSM Higgs doublets can resolve the familiar two-loop discrepancy between the SUSY GUT prediction and the measured value of alpha_3. Our analysis highlights the advantages of the holomorphic scheme, where the perturbative running of gauge couplings is saturated at one loop and further corrections are conveniently described in terms of wavefunction renormalization factors. If the gauge couplings as well as the extra Yukawas are of O(1) at the unification scale, the relevant two-loop correction can be obtained analytically. However, the effect persists also in the weakly-coupled domain, where possible non-perturbative corrections at the GUT scale are under better control.Comment: 26 pages, LaTeX. v6: Important early reference adde

The Orbital Order Parameter in La0.95Sr0.05MnO3 probed by Electron Spin Resonance

The temperature dependence of the electron-spin resonance linewidth in La0.95Sr0.05MnO3 has been determined and analyzed in the paramagnetic regime across the orbital ordering transition. From the temperature dependence and the anisotropy of linewidth and $g$-value the orbital order can be unambiguously determined via the mixing angle of the wave functions of the $e_{\rm g}$-doublet. The linewidth shows a similar evolution with temperature as resonant x-ray scattering results

Yukawa unification in SO(10) with light sparticle spectrum

We investigate supersymmetric SO(10) GUT model with \mu<0. The requirements of top-bottom-tau Yukawa unification, correct radiative electroweak symmetry breaking and agreement with the present experimental data may be met when the soft masses of scalars and gauginos are non-universal. We show how appropriate non-universalities can easily be obtained in the SO(10) GUT broken to the Standard Model. We discuss how values of BR(b-->s \gamma) and (g-2)_\mu simultaneously in a good agreement with the experimental data can be achieved in SO(10) model with \mu<0. In the region of the parameter space preferred by our analysis there are two main mechanisms leading to the LSP relic abundance consistent with the WMAP results. One is the co-annihilation with the stau and the second is the resonant annihilation via exchange of the Z boson or the light Higgs scalar. A very interesting feature of SO(10) models with negative \mu is that they predict relatively light sparticle spectra. Even the heaviest superpartners may easily have masses below 1.5 TeV in contrast to multi-TeV particles typical for models with positive \mu.Comment: 23 pages, 5 figure

Unitarity bounds on low scale quantum gravity

We study the unitarity of models with low scale quantum gravity both in four dimensions and in models with a large extra-dimensional volume. We find that models with low scale quantum gravity have problems with unitarity below the scale at which gravity becomes strong. An important consequence of our work is that their first signal at the Large Hadron Collider would not be of a gravitational nature such as graviton emission or small black holes, but rather linked to the mechanism which fixes the unitarity problem. We also study models with scalar fields with non minimal couplings to the Ricci scalar. We consider the strength of gravity in these models and study the consequences for inflation models with non-minimally coupled scalar fields. We show that a single scalar field with a large non-minimal coupling can lower the Planck mass in the TeV region. In that model, it is possible to lower the scale at which gravity becomes strong down to 14 TeV without violating unitarity below that scale.Comment: 15 page

Solving the mu problem with a heavy Higgs boson

We discuss the generation of the mu-term in a class of supersymmetric models characterized by a low energy effective superpotential containing a term lambda S H_1 H_2 with a large coupling lambda~2. These models generically predict a lightest Higgs boson well above the LEP limit of 114 GeV and have been shown to be compatible with the unification of gauge couplings. Here we discuss a specific example where the superpotential has no dimensionful parameters and we point out the relation between the generated mu-term and the mass of the lightest Higgs boson. We discuss the fine-tuning of the model and we find that the generation of a phenomenologically viable mu-term fits very well with a heavy lightest Higgs boson and a low degree of fine-tuning. We discuss experimental constraints from collider direct searches, precision data, thermal relic dark matter abundance, and WIMP searches finding that the most natural region of the parameter space is still allowed by current experiments. We analyse bounds on the masses of the superpartners coming from Naturalness arguments and discuss the main signatures of the model for the LHC and future WIMP searches.Comment: Extended discussion of the LHC phenomenology, as published on JHEP plus an addendum on the existence of further extremal points of the potential. 47 pages, 16 figure