4,296 research outputs found
X-ray diffraction from shock-loaded polycrystals
X-ray diffraction was demonstrated from shock-compressed polycrystalline
metal on nanosecond time scales. Laser ablation was used to induce shock waves
in polycrystalline foils of Be, 25 to 125 microns thick. A second laser pulse
was used to generate a plasma x-ray source by irradiation of a Ti foil. The
x-ray source was collimated to produce a beam of controllable diameter, and the
beam was directed at the Be sample. X-rays were diffracted from the sample, and
detected using films and x-ray streak cameras. The diffraction angle was
observed to change with shock pressure. The diffraction angles were consistent
with the uniaxial (elastic) and isotropic (plastic) compressions expected for
the loading conditions used. Polycrystalline diffraction will be used to
measure the response of the crystal lattice to high shock pressures and through
phase changes
Systematic review of prognostic importance of extramural venous invasion in rectal cancer
AIM: To systematically review the survival outcomes relating to extramural venous invasion in rectal cancer. METHODS: A systematic review was conducted using PRISMA guidelines. An electronic search was carried out using MEDLINE, EMBASE, CINAHL, Cochrane library databases, Google scholar and Pubmed until October 2014. Search terms were used in combination to yield articles on extramural venous invasion in rectal cancer. Outcome measures included prevalence and 5-year survival rates. These were graphically displayed using Forest plots. Statistical analysis of the data was carried out. RESULTS: Fourteen studies reported the prevalence of extramural venous invasion (EMVI) positive patients. Prevalence ranged from 9%-61%. The pooled prevalence of EMVI positivity was 26% [Random effects: Event rate 0.26 (0.18, 0.36)]. Most studies showed that EMVI related to worse oncological outcomes. The pooled overall survival was 39.5% [Random effects: Event rate 0.395 (0.29, 0.51)]. CONCLUSION: Historically, there has been huge variation in the prevalence of EMVI through inconsistent reporting. However the presence of EMVI clearly leads to worse survival outcomes. As detection rates become more consistent, EMVI may be considered as part of risk-stratification in rectal cancer. Standardised histopathological definitions and the use of magnetic resonance imaging to identify EMVI will improve detection rates in the future
Crucial role of sidewalls in velocity distributions in quasi-2D granular gases
Our experiments and three-dimensional molecular dynamics simulations of
particles confined to a vertical monolayer by closely spaced frictional walls
(sidewalls) yield velocity distributions with non-Gaussian tails and a peak
near zero velocity. Simulations with frictionless sidewalls are not peaked.
Thus interactions between particles and their container are an important
determinant of the shape of the distribution and should be considered when
evaluating experiments on a tightly constrained monolayer of particles.Comment: 4 pages, 4 figures, Added reference, model explanation charified,
other minor change
A numerical investigation on the vortex formation and flow separation of the oscillatory flow in jet pumps
A two-dimensional computational fluid dynamics model is used to predict the
oscillatory flow through a tapered cylindrical tube section (jet pump) placed
in a larger outer tube. Due to the shape of the jet pump, there will exist an
asymmetry in the hydrodynamic end effects which will cause a time-averaged
pressure drop to occur that can be used to cancel Gedeon streaming in a
closed-loop thermoacoustic device. The performance of two jet pump geometries
with different taper angles is investigated. A specific time-domain impedance
boundary condition is implemented in order to simulate traveling acoustic wave
conditions. It is shown that by scaling the acoustic displacement amplitude to
the jet pump dimensions, similar minor losses are observed independent of the
jet pump geometry. Four different flow regimes are distinguished and the
observed flow phenomena are related to the jet pump performance. The simulated
jet pump performance is compared to an existing quasi-steady approximation
which is shown to only be valid for small displacement amplitudes compared to
the jet pump length.Comment: The following article has been accepted by the Journal of the
Acoustical Society of America. After it is published, it will be found at:
http://scitation.aip.org/JAS
Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer
BACKGROUND: Extramural venous invasion (EMVI) is a poor prognostic factor in rectal cancer and identified on magnetic resonance imaging (MRI) (mrEMVI). The clinical relevance of improvement in mrEMVI following neoadjuvant therapy is unknown. This study aimed to demonstrate that regression of mrEMVI following neoadjuvant chemoradiotherapy (CRT) results in improved outcomes and mrEMVI can be used as an imaging biomarker METHODS: Retrospective analysis of prospectively collected data was conducted examining the staging and post-treatment MRIs of patients who had presented with EMVI-positive rectal cancer. All patients had undergone neoadjuvant CRT and curative surgery. Changes in mrEMVI were graded with a new MRI-based TRG scale–mr-vTRG; and related to disease-free survival (DFS). The study fulfilled Reporting Recommendations for Tumour Marker Prognostic Studies criteria for biomarkers. RESULTS: Sixty-two patients were included. Thirty-five patients showed more than 50% fibrosis of mrEMVI (mr-vTRG 1-3); 3-year DFS 87.8% and 9% recurrence. Twenty-seven patients showed less than 50% fibrosis (mr-vTRG 4-5); 3-year DFS 45.8% with 44% recurrence – P<0.0001. On multivariate Cox-regression, only mr-vTRG 4-5 increased risk of disease recurrence – HR=5.748. CONCLUSION: Patients in whom there has been a significant response of EMVI to CRT show improved DFS. Those patients with poor response should be considered for intensive treatment. As an imaging biomarker in rectal cancer, mrEMVI can be used
Jet pumps for thermoacoustic applications: design guidelines based on a numerical parameter study
The oscillatory flow through tapered cylindrical tube sections (jet pumps) is
characterized by a numerical parameter study. The shape of a jet pump results
in asymmetric hydrodynamic end effects which cause a time-averaged pressure
drop to occur under oscillatory flow conditions. Hence, jet pumps are used as
streaming suppressors in closed-loop thermoacoustic devices. A two-dimensional
axisymmetric computational fluid dynamics model is used to calculate the
performance of a large number of conical jet pump geometries in terms of
time-averaged pressure drop and acoustic power dissipation. The investigated
geometrical parameters include the jet pump length, taper angle, waist diameter
and waist curvature. In correspondence with previous work, four flow regimes
are observed which characterize the jet pump performance and dimensionless
parameters are introduced to scale the performance of the various jet pump
geometries. The simulation results are compared to an existing quasi-steady
theory and it is shown that this theory is only applicable in a small operation
region. Based on the scaling parameters, an optimum operation region is defined
and design guidelines are proposed which can be directly used for future jet
pump design.Comment: The following article has been accepted by the Journal of the
Acoustical Society of America. After it is published, it will be found at
http://scitation.aip.org/JAS
- …