167 research outputs found
Conceptual delimitations regarding the terminology used in the methods of investigating the future paper title
The authors propose the conceptual delimitation regarding the terminology used in the methods of investigating the future on the basis of a set of 7 variables. To this end, the hierarchical clusters? method will be used. The outcome of the research will be presented under the form of some clusters of terms with homogeneous meanings, almost synonyms, that would constitute the conceptual delimitation of the termsconceptual delimitation, anticipated future, cluster method
Romanian Tritium for Nuclear Fusion
The demand for tritium is expected to increase when ITER (the International Thermonuclear Experimental Reactor) begins operation in the mid-2020s. Romania is expected to detritiate its CANDU (Canada Deuterium Uranium) units at Cernavoda starting 2024, with the goal of improving radiological safety and reactor performance. Detritiation will result in a significant quantity of tritium being produced and thus Romania has an opportunity to supply tritium for fusion. In this assessment, ITER has been used as a reference device requiring tritium, as the projected tritium extraction schedule from Cernavoda aligns favourably with ITER operation. The findings suggest that Romania is capable of providing a total of 6.2 kg of tritium to ITER over its 20 year operation, generating a potential revenue of 120 M (USD) in the case of zero tritium sales. Greater involvement in future fission-fusion tritium-related activities through experience in tritium technologies is also discussed as a unique opportunity for Romania
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Bite-sized and peer-assisted video-based learning in statistics education: benefits on attainment, attitudes and preferences of university students
The use and acceptance of online learning have increased following the COVID-19 pandemic. This mixed-methods study examined learners' preferences and performance in online learning interactions in relation to two factors: 'bite-sized' learning and 'presenter status' in instructional videos. University students (N = 18) without a mathematical background utilised bite-sized online learning episodes focusing on statistics. Each episode included a 10-minute instructional video followed by an assessment. The videos implemented three alternative 'presenter-status' conditions: lecturer, student-imitating-lecturer or student-peer-tutor. Individual students completed three episodes, one from each presenter-status condition (counterbalanced). Participants presented high performance in the post-episode assessments, irrespective of presenter status. Students also reported remarkably positive views towards bite-sized learning in user-satisfaction questionnaires. Finally, qualitative analysis of open-ended responses and interviews uncovered three main themes: positive learning experiences, divergent attitudes towards video-based learning, and differential preferences for presenter status. These findings have clear implications for teaching and learning in higher education
Exploring the impact of group identity at university on psychological and behavioural outcomes
With respect to supporting student well-being and success, the current research developed a peer support scheme, built on the principles of Social Identity Theory (SIT). This was targeted towards first year undergraduate psychology students, in which measures of collective identity, sense of belonging, group efficacy, happiness and resilience were obtained, along with attendance and academic attainment. Following one academic year of being part of our peer support scheme, participants (N= 90) completed a questionnaire and consented to their attendance and attainment data to be used. It was found that studentsâ collective identity was positively related to their sense of belonging, group efficacy beliefs and happiness. Further, the sense of belonging was a reliable predictor of happiness, but not attendance or academic attainment. Therefore, there is some evidence to suggest that a SIT-driven peer support scheme can support studentsâ psychosocial well-being, although more is needed to ascertain whether this could be developed further to observe any course-related outcomes. Theoretical contributions to SIT are therefore presented, in which the insights can be applied to Higher Education beyond the UK
Rare deleterious germline variants and risk of lung cancer
Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC). Whole exome plus targeted sequencing of germline DNA was performed on 1045 LC cases and 885 controls in the discovery set. To unveil the inherited causal variants, we focused on rare and predicted deleterious variants and small indels enriched in cases or controls. Promising candidates were further validated in a series of 26,803 LCs and 555,107 controls. During discovery, we identified 25 rare deleterious variants associated with LC susceptibility, including 13 reported in ClinVar. Of the five validated candidates, we discovered two pathogenic variants in known LC susceptibility loci, ATM p.V2716A (Odds Ratio [OR] 19.55, 95%CI 5.04â75.6) and MPZL2 p.I24M frameshift deletion (OR 3.88, 95%CI 1.71â8.8); and three in novel LC susceptibility genes, POMC c.*28delT at 3ⲠUTR (OR 4.33, 95%CI 2.03â9.24), STAU2 p.N364M frameshift deletion (OR 4.48, 95%CI 1.73â11.55), and MLNR p.Q334V frameshift deletion (OR 2.69, 95%CI 1.33â5.43). The potential cancer-promoting role of selected candidate genes and variants was further supported by endogenous DNA damage assays. Our analyses led to the identification of new rare deleterious variants with LC susceptibility. However, in-depth mechanistic studies are still needed to evaluate the pathogenic effects of these specific alleles
Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer
AbstractIntroductionThe association between smoking-induced chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is well documented. Recent genome-wide association studies (GWAS) have identified 28 susceptibility loci for LC, 10 for COPD, 32 for smoking behavior, and 63 for pulmonary function, totaling 107 nonoverlapping loci. Given that common variants have been found to be associated with LC in genome-wide association studies, exome sequencing of these high-priority regions has great potential to identify novel rare causal variants.MethodsTo search for disease-causing rare germline mutations, we used a variation of the extreme phenotype approach to select 48 patients with sporadic LC who reported histories of heavy smokingâ37 of whom also exhibited carefully documented severe COPD (in whom smoking is considered the overwhelming determinant)âand 54 unique familial LC cases from families with at least three first-degree relatives with LC (who are likely enriched for genomic effects).ResultsBy focusing on exome profiles of the 107 target loci, we identified two key rare mutations. A heterozygous p.Arg696Cys variant in the coiled-coil domain containing 147 (CCDC147) gene at 10q25.1 was identified in one sporadic and two familial cases. The minor allele frequency (MAF) of this variant in the 1000 Genomes database is 0.0026. The p.Val26Met variant in the dopamine β-hydroxylase (DBH) gene at 9q34.2 was identified in two sporadic cases; the minor allele frequency of this mutation is 0.0034 according to the 1000 Genomes database. We also observed three suggestive rare mutations on 15q25.1: iron-responsive element binding protein neuronal 2 (IREB2); cholinergic receptor, nicotinic, alpha 5 (neuronal) (CHRNA5); and cholinergic receptor, nicotinic, beta 4 (CHRNB4).ConclusionsOur results demonstrated highly disruptive risk-conferring CCDC147 and DBH mutations
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