31 research outputs found
Analysis of homocysteine and thiol-containing compounds using the heterocyclic disulfides
ΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ Π°ΠΌΠΈΠ½ΠΎΡΠΈΠΎΠ»Ρ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΠΌΠ°Π»ΠΎΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΡΠΌ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ Π² ΡΠ»ΡΡΡΠ°ΡΠΈΠΎΠ»Π΅ΡΠΎΠ²ΠΎΠΌ ΠΈ Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ, ΠΏΠΎΡΡΠΎΠΌΡ Π΄Π»Ρ ΠΈΡ
Π°Π½Π°Π»ΠΈΠ·Π° Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡ Π΄Π΅ΡΠΈΠ²Π°ΡΠΈΠ·Π°ΡΠΈΡ. ΠΠ΅ΡΠΈΠ²Π°ΡΠΈΠ·ΠΈΡΡΡΡΠΈΠΉ Π°Π³Π΅Π½Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΠ΅Ρ Ρ ΡΠΈΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ Π°Π½Π°Π»ΠΈΡΠ° Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎ ΠΏΠΎΠ³Π»ΠΎΡΠ°ΡΡΠ΅Π³ΠΎ Π² Π΄Π»ΠΈΠ½Π½ΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΏΠ΅ΠΊΡΡΠ°. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π΄Π΅ΡΠΈΠ²Π°ΡΠΈΠ·ΠΈΡΡΡΡΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² ΡΠ°ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΡΡ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π°Π½Π°Π»ΠΈΠ·Π° Ρ ΠΈΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΏΡΠΎΡΡΠΎΡΠΎΠΉ ΠΈ ΡΠΎΡΠ½ΠΎΡΡΡΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΠ΅ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ Π΄ΠΈΡΠΈΠΎΠ΄ΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½ ΠΈ 5,5β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ-(2-Π½ΠΈΡΡΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°), ΠΈΠΌΠ΅ΡΡ ΡΡΠ΄ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ², ΠΊ ΡΠΈΡΠ»Ρ ΠΊΠΎΡΠΎΡΡΡ
ΠΎΡΠ½ΠΎΡΡΡΡΡ ΡΠ·ΠΊΠΈΠΉ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ pH, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ Π½ΠΈΠ·ΠΊΠ°Ρ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ½ΠΎΡΡΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ. ΠΠΎΡΡΠΎΠΌΡ ΠΏΠΎΠΈΡΠΊ Π½ΠΎΠ²ΡΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅ΡΡΡ. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ 2,2β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Π±Π΅Π½Π·ΠΎΠΊΡΠ°Π·ΠΎΠ»] ΠΈ 8,8β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Ρ
ΠΈΠ½ΠΎΠ»ΠΈΠ½]. ΠΠ·ΡΡΠ΅Π½Π° ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½ΠΎΠΌ ΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠΌΠΈ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Π°ΠΌΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ pH Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π½ΠΈΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΠΎΡΠ½ΡΠ΅ ΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π·Π° (ΠΠ), Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΠΠΠ₯) ΠΈ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΎ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ (ΠΏΡΠ΅Π΄Π΅Π» ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° 1.1Β·10-6-7.8Β·10-6 Π, ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠ΅ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΠ΅ 1.5-4.6 %). ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΡΠ»ΡΡΠ³ΠΈΠ΄ΡΠΈΠ»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ Π² ΠΎΠ±ΡΠ°Π·ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠ½Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ 2,2β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Π±Π΅Π½Π·ΠΎΠΊΡΠ°Π·ΠΎΠ»Π°] ΠΈ 8,8β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Ρ
ΠΈΠ½ΠΎΠ»ΠΈΠ½Π°] ΠΈ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠ³ΠΎ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ 4,4β²-Π΄ΠΈΡΠΈΠΎΠ΄ΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½Π°, ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π±Π»ΠΈΠ·ΠΊΠΈ, ΡΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΠΏΡΠΈΠΌΠ΅Π½ΠΈΠΌΠΎΡΡΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² Π² Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΠ΅Π°Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ².Biological low-molecular aminothiols, such as homocysteine, are characterized by the weak absorption in the UV β visible range. Therefore, aminothiols analysis requires using thiol-specific chemosensors or derivatization procedure. Heterocyclic disulfides belong to a large group of derivatizing agents. However, the disulfides widely used in the analytical practice, such as 5,5'-dithiobis-(2-nitrobenzoic acid), have several disadvantages: limited acceptable pH range, low sensitivity, susceptibility to hydrolisys. Hence, the search for the effective derivatizing agents continues. In the current work, 2,2'-dithiobis[benzoxazole] and 8,8'-dithiobis-quinoline disulfides were used for the analysis of homocysteine. Precise and sensitive methods (homocysteine detection limit in the range of 1.1Β·10-6β7.8Β·10-6 M, relative standard deviation in the range of 1.5β4.6%) for the homocysteine determination have been developed, including spectrophotometric method, capillary electrophoresis (CE), high-performance liquid chromatography (HPLC) and kinetic method with the spectrophotometric detection. The proposed disulfides have also been successfully used in the analysis of sulfhydryl groups content in the sample of human urine
On the Opportunities of Using the Indices of Lipid Peroxidation β Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women
Background: The prevalence of varicose veins of small pelvic veins in women of reproductive age varies widely β from 5.4 to 80 %, due to the low specificity and low sensitivity of clinical diagnostic techniques, and the absence of biomarkers that can be used to identify the formation and progression of varicose veins of small pelvic veins in women.Aims: To identify changes in the levels of parameters of the system βlipid peroxidation β antioxidant protectionβ with the development of varicose veins of the pelvis in women, as well as the possibility of their diagnostic use.Materials and methods: We examined 200 women with clinical signs of varicose veins of small pelvis. Control group included 30 women without any pathology of venous system. Treatment group included 137 women with varicose veins of small pelvis: with mild degree of severity β 39 women, with moderate degree of severity β 65 women, with severe degree of severity β 33 women. We performed comparative analysis of lipid peroxidation β antioxidant defense system in women with and without varicose veins of small pelvis taking into account the severity degrees of pathological process.Results: We obtained the most informative indices for lipid peroxidation β antioxidant defense processes in blood of women with varicose veins of small pelvis: concentration of diene conjugate (DC) for the mild degree of severity of pathological process, lipid hydroperoxide (LHP), DC and malonic dialdehyde (MDA) β for the moderate and severe degree of severity, and also changes in the activity of antioxidant enzymes with increase of the severity of the disease. Assessment of the level of catalase (Cat) and glutathione peroxidase (GP) showed their highest informative value at the mild degree of severity. Concentrations of glutathione reductase (GR), glutathione S-transferase (GST) and reduced glutathione (GSH) are more statistically significant markers for severe forms of pathological process.Conclusions: Our research showed the relevance and advisability of the studying the levels of lipid peroxidation β antioxidant defense indices in women with varicose veins of small pelvis. We registered the highest diagnostic value of DC, Cat and GP in the beginning of the disease and of LHP, DC, MDA, GR, GST and GSH β at severe forms of the pathological process. We obtained reference values for DC, MDA, Cat, SOD and GP concentration that can be considered as the predictors of the development of varicose veins of small pelvis
Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against AΞ² and AΞ²-Metal Complexes Toxicity
It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of Ξ²-amyloid aggregation (AΞ²), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to AΞ² and or to AΞ²-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties
The Impact of eHealth on the Quality and Safety of Health Care: A Systematic Overview
Aziz Sheikh and colleagues report the findings of their systematic overview that assessed the impact of eHealth solutions on the quality and safety of health care
CONTEXT AND EMPIRICAL APPROACH TO FORMATION OF MATHEMATICAL COMPETENCE IN STUDENTS OF HUMANITARIAN TRAINING DIRECTIONS AT UNIVERSITY
The article deals with the formation of studentsβ mathematical competence in higher humanitarian education. The scientific literature analysis and pedagogical experience has shown that in spite of the numerous studies conducted in this area, the idea of coupling mathematical education of the humanitarians with their cultural, methodological and professional training remains. In our opinion, the design of mathematical training of the humanitarians must rely on the theory of activity, which brings together the main statements of methodology, pedagogy, psychology, such as the principles and methods of teaching, the problems of the peculiarities of studentsβ thinking, the increase of the level of their cognitive activity, the personβs education as a whole.The article presents the components of mathematical competence, criteria indicators, stages and levels of its formation. For the formation of mathematical competence it is proposed to apply context- empirical approach and developed on the basis of its organizational and pedagogical model (the main elements of this model are described in the article). In conclusion the pedagogical conditions of effective formation of mathematical competence in students in the system profile of humanitarian education are highlighted and revealed
ΠΠΠΠ ΠΠΠΠΠΠΠΠ ΠΠΠΠΠ¦ΠΠ‘Π’ΠΠΠΠ Π Π’ΠΠΠΠ‘ΠΠΠΠ ΠΠΠ©ΠΠ₯ Π‘ΠΠΠΠΠΠΠΠΠ Π‘ Π‘ΠΠΠΠ¬ΠΠΠΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ¦ΠΠΠΠΠ§ΠΠ‘ΠΠΠ₯ ΠΠΠ‘Π£ΠΠ¬Π€ΠΠΠΠ
Biological low-molecular aminothiols, such as homocysteine, are characterized by the weak absorption in the UV β visible range. Therefore, aminothiols analysis requires using thiol-specific chemosensors or derivatization procedure. Heterocyclic disulfides belong to a large group of derivatizing agents. However, the disulfides widely used in the analytical practice, such as 5,5'-dithiobis-(2-nitrobenzoic acid), have several disadvantages: limited acceptable pH range, low sensitivity, susceptibility to hydrolisys. Hence, the search for the effective derivatizing agents continues. In the current work, 2,2'-dithiobis[benzoxazole] and 8,8'-dithiobis-quinoline disulfides were used for the analysis of homocysteine. Precise and sensitive methods (homocysteine detection limit in the range of 1.1Β·10-6β7.8Β·10-6 M, relative standard deviation in the range of 1.5β4.6%) for the homocysteine determination have been developed, including spectrophotometric method, capillary electrophoresis (CE), high-performance liquid chromatography (HPLC) and kinetic method with the spectrophotometric detection. The proposed disulfides have also been successfully used in the analysis of sulfhydryl groups content in the sample of human urine.Keywords: homocysteine, aminothiols, 2,2'-dithiobis[benzoxazole], 8,8'-dithiobis-quinolineΒ DOI: http://dx.doi.org/10.15826/analitika.2022.26.3.005Β A.A. Shcherbatykh1, O. I. Askalepova1, I. A. Estrin2Β 1Southern Federal University, Department of Chemistry,Zorge St. 7, 344090, Rostov-on-Don, Russian Federation2Rostov State Transport University,Β Rostovskogo Strelkovogo Polka Narodnogo Opolcheniya Sq. 2, 344038, Rostov-on-Don, Russian FederationΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ Π°ΠΌΠΈΠ½ΠΎΡΠΈΠΎΠ»Ρ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΠΌΠ°Π»ΠΎΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΡΠΌ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ Π² ΡΠ»ΡΡΡΠ°ΡΠΈΠΎΠ»Π΅ΡΠΎΠ²ΠΎΠΌ ΠΈ Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ, ΠΏΠΎΡΡΠΎΠΌΡ Π΄Π»Ρ ΠΈΡ
Π°Π½Π°Π»ΠΈΠ·Π° Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡ Π΄Π΅ΡΠΈΠ²Π°ΡΠΈΠ·Π°ΡΠΈΡ. ΠΠ΅ΡΠΈΠ²Π°ΡΠΈΠ·ΠΈΡΡΡΡΠΈΠΉ Π°Π³Π΅Π½Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΠ΅Ρ Ρ ΡΠΈΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ Π°Π½Π°Π»ΠΈΡΠ° Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎ ΠΏΠΎΠ³Π»ΠΎΡΠ°ΡΡΠ΅Π³ΠΎ Π² Π΄Π»ΠΈΠ½Π½ΠΎΠ²ΠΎΠ»Π½ΠΎΠ²ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΏΠ΅ΠΊΡΡΠ°. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π΄Π΅ΡΠΈΠ²Π°ΡΠΈΠ·ΠΈΡΡΡΡΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² ΡΠ°ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΡΡ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π°Π½Π°Π»ΠΈΠ·Π° Ρ ΠΈΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΏΡΠΎΡΡΠΎΡΠΎΠΉ ΠΈ ΡΠΎΡΠ½ΠΎΡΡΡΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΠ΅ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ Π΄ΠΈΡΠΈΠΎΠ΄ΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½ ΠΈ 5,5β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ-(2-Π½ΠΈΡΡΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°), ΠΈΠΌΠ΅ΡΡ ΡΡΠ΄ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ², ΠΊ ΡΠΈΡΠ»Ρ ΠΊΠΎΡΠΎΡΡΡ
ΠΎΡΠ½ΠΎΡΡΡΡΡ ΡΠ·ΠΊΠΈΠΉ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ pH, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ Π½ΠΈΠ·ΠΊΠ°Ρ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ½ΠΎΡΡΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ. ΠΠΎΡΡΠΎΠΌΡ ΠΏΠΎΠΈΡΠΊ Π½ΠΎΠ²ΡΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅ΡΡΡ. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ 2,2β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Π±Π΅Π½Π·ΠΎΠΊΡΠ°Π·ΠΎΠ»] ΠΈ 8,8β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Ρ
ΠΈΠ½ΠΎΠ»ΠΈΠ½]. ΠΠ·ΡΡΠ΅Π½Π° ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½ΠΎΠΌ ΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠΌΠΈ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Π°ΠΌΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ pH Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π½ΠΈΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΠΎΡΠ½ΡΠ΅ ΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π·Π° (ΠΠ), Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΠΠΠ₯) ΠΈ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΎ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ (ΠΏΡΠ΅Π΄Π΅Π» ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° 1.1Β·10-6-7.8Β·10-6 Π, ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠ΅ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΠ΅ 1.5-4.6 %). ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Ρ ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΡΠ»ΡΡΠ³ΠΈΠ΄ΡΠΈΠ»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ Π² ΠΎΠ±ΡΠ°Π·ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠ½Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ 2,2β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Π±Π΅Π½Π·ΠΎΠΊΡΠ°Π·ΠΎΠ»Π°] ΠΈ 8,8β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Ρ
ΠΈΠ½ΠΎΠ»ΠΈΠ½Π°] ΠΈ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠ³ΠΎ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ 4,4β²-Π΄ΠΈΡΠΈΠΎΠ΄ΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½Π°, ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π±Π»ΠΈΠ·ΠΊΠΈ, ΡΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΠΏΡΠΈΠΌΠ΅Π½ΠΈΠΌΠΎΡΡΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² Π² Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΠ΅Π°Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ².ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½, Π°ΠΌΠΈΠ½ΠΎΡΠΈΠΎΠ»Ρ, 2,2β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Π±Π΅Π½Π·ΠΎΠΊΡΠ°Π·ΠΎΠ»], 8,8β²-Π΄ΠΈΡΠΈΠΎΠ±ΠΈΡ[Ρ
ΠΈΠ½ΠΎΠ»ΠΈΠ½]DOI: http://dx.doi.org/10.15826/analitika.2022.26.3.00