THE CYCLICAL NATURE OF POLITICS AND THE U.S. FOOD SYSTEM

Agricultural and Food Policy, Political Economy,

Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis

This article is available open access through the publisher’s website. Copyright @ 2009 Oxford University Press.Background - Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world. Historically, susceptibility to IA has been associated with prolonged neutropenia; however, IA has now become a major problem in patients on calcineurin inhibitors and allogenic hematopoetic stem cell transplant patients following engraftment. These observations suggest complex cellular mechanisms govern immunity to IA. Methods - To characterize the key early events that govern outcome from infection with Aspergillus fumigatus we performed a comparative immunochip microarray analysis of the pulmonary transcriptional response to IA between cyclophosphamide-treated mice and immunocompetent mice at 24 h after infection. Results - We demonstrate that death due to infection is associated with a failure to generate an incremental interferon-γ response, increased levels of interleukin-5 and interleukin-17a transcript, coordinated expression of a network of tumor necrosis factor–α-related genes, and increased levels of tumor necrosis factor–α. In contrast, clearance of infection is associated with increased expression of a number genes encoding proteins involved in innate pathogen clearance, as well as apoptosis and control of inflammation. Conclusion - This first organ-level immune response transcriptional analysis for IA has enabled us to gain new insights into the mechanisms that govern fungal immunity in the lung.The BBSRC, CGD Research Trust, and the MRC

Case-Building Behavior, Persistence, and Emergence Success of \u3ci\u3ePycnopsyche Guttifer\u3c/i\u3e (Walker) (Trichoptera: Limnephilidae) in Laboratory and \u3ci\u3ein situ\u3c/i\u3e Environments: Potential Trade-Offs of Material Preference

When removed from their cases in a non-flow laboratory environment, 5th instar Pycnopsyche guttifer (Walker) larvae were always successful in constructing a new case within 24 h when woody debris was present as a material choice. Most were successful within 1 h. Larvae were never successful at case building in the absence of wood in a non-flow environment. These laboratory-constructed ‘emergency cases’ were flimsy, lacking in shape, and larger than field cases. Laboratory case size, shape, and material preference remained constant after repeated daily evacuations over a series of 10 days. Larvae could be induced to construct a case composed of mineral particles only in the absence of wood and when placed in a laboratory stream with simulated flow conditions, or in situ in a natural stream. The emergence success of P. guttifer specimens induced to build these mineral cases, however, was significantly higher than that of larvae remaining in their field cases or of larvae that built wood cases. This result is likely due to a fungal infection that affected only larvae in wood cases. Our results demonstrate a scenario where a clearly non-preferred case construction material appears to increase survival

Computation of incompressible viscous flows through artificial heart devices with moving boundaries

The extension of computational fluid dynamics techniques to artificial heart flow simulations is illustrated. Unsteady incompressible Navier-Stokes equations written in 3-D generalized curvilinear coordinates are solved iteratively at each physical time step until the incompressibility condition is satisfied. The solution method is based on the pseudo compressibility approach and uses an implicit upwind differencing scheme together with the Gauss-Seidel line relaxation method. The efficiency and robustness of the time accurate formulation of the algorithm are tested by computing the flow through model geometries. A channel flow with a moving indentation is computed and validated with experimental measurements and other numerical solutions. In order to handle the geometric complexity and the moving boundary problems, a zonal method and an overlapping grid embedding scheme are used, respectively. Steady state solutions for the flow through a tilting disk heart valve was compared against experimental measurements. Good agreement was obtained. The flow computation during the valve opening and closing is carried out to illustrate the moving boundary capability

Research Factsheet: Woodfuel experiment - North Thurlbar, Newton Rigg

An experiment has been set up to assess the economic viability and environmental impacts of woodfuel harvesting in North Thurlbar, a small wood land on the University of Cumbria Newton Rigg campus estate. This factsheet describes the aim of the study and the experiment design

Does environment affect the star formation histories of early-type galaxies?

Differences in the stellar populations of galaxies can be used to quantify the effect of environment on the star formation history. We target a sample of early-type galaxies from the Sloan Digital Sky Survey in two different environmental regimes: close pairs and a general sample where environment is measured by the mass of their host dark matter halo. We apply a blind source separation technique based on principal component analysis, from which we define two parameters that correlate, respectively, with the average stellar age (eta) and with the presence of recent star formation (zeta) from the spectral energy distribution of the galaxy. We find that environment leaves a second order imprint on the spectra, whereas local properties - such as internal velocity dispersion - obey a much stronger correlation with the stellar age distribution.Comment: 5 pages, 2 figures. Proceedings of JENAM 2010, Symposium 2: "Environment and the formation of galaxies: 30 years later

Continuous functions on products of compact Hausdorff spaces

We investigated the spaces of continuous functions on countable products of compact Hausdorff spaces. Our main object here is to extend the discussion to arbitrary products of compact Hausdorff spaces. We prove the following theorems in Section 3

Sub-wavelength focusing meta-lens

We show that planar a plasmonic metamaterial with spatially variable meta-atom parameters can focus transmitted light into sub-wavelength hot-spots located beyond the near-field of the metamaterial. By nano-structuring a gold film we created an array of meta-lenses generating foci of 160 nm (0.2{\lambda}) in diameter when illuminated by a wavelength of 800 nm. We attribute the occurrence of sub-wavelength hotspots beyond the near field to the phenomenon of superoscillation