Malignant tumors arising de novo in immunosuppressed organ transplant recipients

De novo malignant tumors have been observed throughout the world in 75 chronic survivors of organ transplantation, including 16 of our own patients. The incidence of tumors was approximately 80 times greater than in the average population in a comparable age range. Chronic uremia may have predisposed to the development of some of the tumors, but this has not yet been proved. It seems clear that the predominant etiology was chronic immunosuppression post-transplantation. Forty-four of the patients had epithelial tumors and in 31 the lesions were of mesenchymal origin. On the average the malignancies appeared 29 months after transplantation. Lymphomas showed an unusual- predilection for involvement of the central nervous system. Carcinomas of the skin, lip, and uterine cervix were successfully treated by conventional techniques. On the other hand, carcinomas of the thoracic or abdominal organs and mesenchymal tumors led or contributed to early death in most cases. For this reason drastic reduction or even discontinuance of immunosuppression should be considered in the management of these latter tumors. © 1972 by The Williams & Wilkins Co

Malignant lymphomas in transplantation patients: a review of the world experience.

Malignant lymphomas developed in 9 renal homograft recipients treated at widely separated transplantation centers. The development of these tumors appears to be an indirect complication of organ transplantation and/or the measures taken to prevent rejection. A further complication may be an increased incidence of epithelial tumors. It also seems likely that immune paralysis may accelerate the growth of metastases

THE TREATMENT OF PERFORATED PEPTIC ULCER

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RUPTURED ABDOMINAL AORTIC ANEURYSMS

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The fate of failed renal homografts retained after retransplantation

The fate of nonfunctioning or poorly functioning renal homografts which were left in situ at retransplantation was studied in 28 patients. In one recipient, lethal septicemia developed secondary to necrosis as well as infection of a retained intraabdominal graft. In three other patients, subsequent symptoms developed from retained extraperitoneal pelvic grafts, and these kidneys were removed without complication. It is suggested that grafts placed extraperitoneally can be left in place if retransplantation becomes necessary, provided that there is careful follow up study for signs of necrosis or infection. Removal of the kidney graft then may be performed electively at a later time, or this may never become necessary in a significant number of patients

Urban space and pervasive systems

In this paper we present an early approach for developing a theoretical framework and understanding for designing pervasive systems as an integral part of the urban landscape. The research will be conducted in the city of Bath as part of the CityWare project, in a heritage environment with tourist attractions. Here we propose to investigate the application of research methods based on Space Syntax, which encompasses a set of theories and techniques for the analysis of space and spatial patterns, as a framework for understanding the complex relationship between pervasive systems, urban space and society in general; and the impact of the deployment of pervasive systems on people’s relationships to heritage, and to each other in particular