Analysis of Herpes Simplex Virus-Specific T Cells in the Murine Female Genital Tract Following Genital Infection with Herpes Simplex Virus Type 2

AbstractA murine model of genital infection with a thymidine kinase-deficient (tk-) strain of herpes simplex virus type 2 (HSV-2) was utilized to examine the development of the local T cell response in the genital mucosa and draining genital lymph nodes (gLN). HSV-specific cytokine-secreting T cells were detected in the gLN 4 days postintravaginal inoculation but not in the urogenital tract or spleen until 5 days postinoculation, suggesting the cellular immune response originates in the gLN. More CD4+ than CD8+ gLN T cells were detected by flow cytometric analysis following primary vaginal inoculation and the majority of HSV-specific gLN T cells detected by ELISPOT were CD4+ and Th1-like based on secretion of IFNγ and not IL-4 or IL-5. A similar population of HSV-specific memory T cells persisted in the genital tract 2 months following HSV-2 tk- genital inoculation. These data suggest that the urogenital cellular immune response elicited in mice following genital inoculation with HSV-2 tk- is predominantly CD4+ and Th1-like, resembling that observed in humans. The results of this study are important for the rational design of vaccines capable of inducing protective immunity in the genital tract

Orthosymplectically invariant functions in superspace

The notion of spherically symmetric superfunctions as functions invariant under the orthosymplectic group is introduced. This leads to dimensional reduction theorems for differentiation and integration in superspace. These spherically symmetric functions can be used to solve orthosymplectically invariant Schroedinger equations in superspace, such as the (an)harmonic oscillator or the Kepler problem. Finally the obtained machinery is used to prove the Funk-Hecke theorem and Bochner's relations in superspace.Comment: J. Math. Phy

A note on quantization operators on Nichols algebra model for Schubert calculus on Weyl groups

We give a description of the (small) quantum cohomology ring of the flag variety as a certain commutative subalgebra in the tensor product of the Nichols algebras. Our main result can be considered as a quantum analog of a result by Y. Bazlov

Applications of BGP-reflection functors: isomorphisms of cluster algebras

Given a symmetrizable generalized Cartan matrix $A$, for any index $k$, one can define an automorphism associated with $A,$ of the field $\mathbf{Q}(u_1, >..., u_n)$ of rational functions of $n$ independent indeterminates $u_1,..., u_n.$ It is an isomorphism between two cluster algebras associated to the matrix $A$ (see section 4 for precise meaning). When $A$ is of finite type, these isomorphisms behave nicely, they are compatible with the BGP-reflection functors of cluster categories defined in [Z1, Z2] if we identify the indecomposable objects in the categories with cluster variables of the corresponding cluster algebras, and they are also compatible with the "truncated simple reflections" defined in [FZ2, FZ3]. Using the construction of preprojective or preinjective modules of hereditary algebras by Dlab-Ringel [DR] and the Coxeter automorphisms (i.e., a product of these isomorphisms), we construct infinitely many cluster variables for cluster algebras of infinite type and all cluster variables for finite types.Comment: revised versio

Asymptotic Learning Curve and Renormalizable Condition in Statistical Learning Theory

Bayes statistics and statistical physics have the common mathematical structure, where the log likelihood function corresponds to the random Hamiltonian. Recently, it was discovered that the asymptotic learning curves in Bayes estimation are subject to a universal law, even if the log likelihood function can not be approximated by any quadratic form. However, it is left unknown what mathematical property ensures such a universal law. In this paper, we define a renormalizable condition of the statistical estimation problem, and show that, under such a condition, the asymptotic learning curves are ensured to be subject to the universal law, even if the true distribution is unrealizable and singular for a statistical model. Also we study a nonrenormalizable case, in which the learning curves have the different asymptotic behaviors from the universal law

Splines and Wavelets on Geophysically Relevant Manifolds

Analysis on the unit sphere $\mathbb{S}^{2}$ found many applications in seismology, weather prediction, astrophysics, signal analysis, crystallography, computer vision, computerized tomography, neuroscience, and statistics. In the last two decades, the importance of these and other applications triggered the development of various tools such as splines and wavelet bases suitable for the unit spheres $\mathbb{S}^{2}$, $\>\>\mathbb{S}^{3}$ and the rotation group $SO(3)$. Present paper is a summary of some of results of the author and his collaborators on generalized (average) variational splines and localized frames (wavelets) on compact Riemannian manifolds. The results are illustrated by applications to Radon-type transforms on $\mathbb{S}^{d}$ and $SO(3)$.Comment: The final publication is available at http://www.springerlink.co

On the reduction of the multidimensional Schroedinger equation to a first order equation and its relation to the pseudoanalytic function theory

Given a particular solution of a one-dimensional stationary Schroedinger equation (SE) this equation of second order can be reduced to a first order linear differential equation. This is done with the aid of an auxiliary Riccati equation. We show that a similar fact is true in a multidimensional situation also. We consider the case of two or three independent variables. One particular solution of (SE) allows us to reduce this second order equation to a linear first order quaternionic differential equation. As in one-dimensional case this is done with the aid of an auxiliary Riccati equation. The resulting first order quaternionic equation is equivalent to the static Maxwell system. In the case of two independent variables it is the Vekua equation from theory of generalized analytic functions. We show that even in this case it is necessary to consider not complex valued functions only, solutions of the Vekua equation but complete quaternionic functions. Then the first order quaternionic equation represents two separate Vekua equations, one of which gives us solutions of (SE) and the other can be considered as an auxiliary equation of a simpler structure. For the auxiliary equation we always have the corresponding Bers generating pair, the base of the Bers theory of pseudoanalytic functions, and what is very important, the Bers derivatives of solutions of the auxiliary equation give us solutions of the main Vekua equation and as a consequence of (SE). We obtain an analogue of the Cauchy integral theorem for solutions of (SE). For an ample class of potentials (which includes for instance all radial potentials), this new approach gives us a simple procedure allowing to obtain an infinite sequence of solutions of (SE) from one known particular solution

The Shapovalov determinant for the Poisson superalgebras

Among simple Z-graded Lie superalgebras of polynomial growth, there are several which have no Cartan matrix but, nevertheless, have a quadratic even Casimir element C_{2}: these are the Lie superalgebra k^L(1|6) of vector fields on the (1|6)-dimensional supercircle preserving the contact form, and the series: the finite dimensional Lie superalgebra sh(0|2k) of special Hamiltonian fields in 2k odd indeterminates, and the Kac--Moody version of sh(0|2k). Using C_{2} we compute N. Shapovalov determinant for k^L(1|6) and sh(0|2k), and for the Poisson superalgebras po(0|2k) associated with sh(0|2k). A. Shapovalov described irreducible finite dimensional representations of po(0|n) and sh(0|n); we generalize his result for Verma modules: give criteria for irreducibility of the Verma modules over po(0|2k) and sh(0|2k)

Ray helicity: a geometric invariant for multi-dimensional resonant wave conversion

For a multicomponent wave field propagating into a multidimensional conversion region, the rays are shown to be helical, in general. For a ray-based quantity to have a fundamental physical meaning it must be invariant under two groups of transformations: congruence transformations (which shuffle components of the multi-component wave field) and canonical transformations (which act on the ray phase space). It is shown that for conversion between two waves there is a new invariant not previously discussed: the intrinsic helicity of the ray