ПУТИ ПОВЫШЕНИЯ РОЛИ ИННОВАЦИОННЫХ ЯРМАРОК В АКТИВИЗАЦИИ ИННОВАЦИОННЫХ ПРОЦЕССОВ В УЗБЕКИСТАНЕ

This article is devoted to revealing the role of innovative trade fairs in encouraging the innovation process in Uzbekistan and analysis of their effect for the economy. The article represents correlation - regression analysis of the impact of the volume of trade fair transactions and a number of innovations implemented in the real sector of the economy on the volume of the innovative products manufactured in the economy. Moreover, the article provides recommendations aimed at using venture capital funds as the source of financing innovation projects as well as a trade fair mechanism of initiating cooperation between innovative beneficiaries and donors of venture funds.Статья посвящена выявлению роли проводимых ежегодных инновационных ярмарок в стимулировании инновационных процессов в Узбекистане и анализу соответствующего эффекта для экономики. В работе проведен корреляционно-регрессионный анализ влияния объема ярмарочных сделок и количества внедренных инноваций в реальный сектор, на объем выпускаемой инновационной продукции в экономике. Даны рекомендации по использованию венчурного капитала как источника финансирования инновационных проектов, а также ярмарочного механизма инициирования сотрудничества инновационных бенефициаров и венчурных доноров

Influence temperature and strong magnetic field on oscillations of density of energy states in heterostructures with quantum wells Hgcdte/Cdhgte

For the first time, the influence of temperature and a transverse strong magnetic field on the oscillations of the density of energy states is studied in the conduction band of heterostructures with quantum wells HgCdTe/CdHgTe. Analytical expressions are derived for oscillations of the density of states in quantum-dimensional heterostructural materials in the presence of transverse quantizing magnetic fields with a parabolic dispersion law. A new mathematical model has been developed for calculating the temperature dependence of the density of states oscillations in nanosized heterostructural materials under the action of a transverse quantizing magnetic field

Current and future use of dipyridamole in patients with COVID-19

Current use of dipyridamole in COVID-19 is mainly based on its antithrombotic activity, since there is no robust clinical effectiveness data. The decision to use dipyridamole in COVID-19 should be individualized, considering the experimental nature of this treatment

Temperature dependence of width band gap in Inxga1-Xasquantum well in presence of transverse strong magnetic field

This article investigated the temperature dependence of the width band gap in InxGa1-xAs quantum well in the presence of a transverse strong magnetic field. A new method was proposed for determining the width band gap of GaAs/InxGa1-xAs heterostructures based on a InxGa1-xAs quantum well in the presence of a magnetic field and temperature. An analytical expression is obtained for calculating the width band gap of a rectangular quantum well at various magnetic fields and temperatures

Modeling the Temperature Dependence of Shubnikov-De Haas Oscillations in Light-Induced Nanostructured Semiconductors

In this work, the influence of light on the temperature dependence of transverse magnetoresistance oscillations is studied. A generalized mathematical expression that calculates the temperature and light dependence of the quasi-Fermi levels of small-scale p-type semiconductor structures in a quantizing magnetic field is derived. New analytical expressions have been found to represent the temperature dependence of transverse differential magnetoresistance oscillations in dark and light situations, taking into account the effect of light on the oscillations of the Fermi energy of small-scale semiconductor structures. A mathematical model has been developed that determines the light dependence of the second-order derivative of the transverse magnetoresistance oscillations of p‑type semiconductors with quantum wells by magnetic field induction. A new theory is proposed, which explains the reasons for the significant shift of the differential magnetoresistance oscillations along the vertical axis measured in the experiment for dark and light conditions

Upheaval buckling of underground pipelines of complex configuration located in liquefied soils

The problem of loss of stability of underground pipelines with a middle part in the form of a straight or П-shaped part located in liquefied soils is considered in the article. The pipeline lifting process occurs under the action of buoyancy force in the liquefied soil zone and then under the action of the longitudinal compressive force that appears due to the temperature of the transported product and its pressure. The problem is solved by the finite element method. The results are presented as a table and graphs of changes in the values of transverse displacements along the coordinate depending on the pipeline geometric characteristics and the soil rheological properties. It is established that the П-shaped part is a damper against pipeline buckling

Surgical treatment of extended spongy urethral strictures in men: minimizing the risks of narrowing in the anastomotic zones between the buccal graft and the native urethra using the dorsal inlay technique

Introduction. Currently, the most common method of treating extended urethral strictures is augmentation urethroplasty using oral mucosa grafts. Analysis of the long-term outcomes of this surgery type shows a high incidence of relapses and complications.Purpose of the study. To improve the outcomes of augmentation urethroplasty, in particular the dorsal inlay (Asopa) technique, in patients with extended spongy urethral strictures by minimizing the risk of recurrent strictures.Materials and methods. The study is based on an analysis of the surgery in 90 patients (aged 18-72 years) with extended spongy urethral strictures. Seventy patients (group I) underwent dorsal inlay augmentation urethroplasty according to the Asopa technique, and 20 patients (group II) — according to the author's modified technique. Statistical data analysis was carried out using the SPSS ver.26 software (SPSS Inc. Chicago, IL, USA).Results. A comparative analysis of the course of the early postoperative period showed a lower number of complications in group II patients compared to group I — 20.0% versus 34.3%, respectively. The recurrent strictures were registered for groups I and II in 18.8% and 5.6% of cases 6 months after surgery, respectively. The recurrent urethral narrowing was most often localized in the area of distal anastomosis between the buccal graft and the native urethra in patients from both groups.Conclusion. The modified dorsal inlay augmentation urethroplasty technique developed and implemented in clinical practice by increasing the internal urethral lumen in the areas of proximal and distal anastomosis between the buccal graft and the native spongy urethral body allows minimizing the risks of recurrent urethral narrowing after augmentation urethroplasty

Study of the hygrometric condition of cement stone and concrete

Cement systems are thermodynamically non-equilibrium, non-linear systems. Since it is far from equilibrium, it must be characterised by structure formation processes. Here it is necessary to consider the definition of ‘structure formation’. This term is used in two meanings. The first is generally accepted in concrete science -the formation of mechanical bonds between the dispersed particles of a solidifying system as a result of ongoing chemical and physicochemical processes, culminating in the formation of a solid body -the cement stone and concrete. The second meaning of the term describes the emergence of dissipative structures, i.e. the destruction of the initial homogeneity of the system due to the emergence of streams, concentration gradients, chemical waves, etc. By measuring the parameters of the resulting dissipative structures of different formation methods, it is possible to assess the degree of disequilibrium in the solidifying system and hence the directed methods of structure formation and structure optimisation. It should also be noted that a non-linear, non-equilibrium hydration process leading to a concentration potential difference proceeds with equal probability in all directions. Applying a gradient of a high-intensity physical field to the disperse system, one should expect a synchronisation of the fluctuations of the concentration potential of local areas of the disperse system, which will result in a sharp increase of the physical and mechanical properties of the hydration products of the binder and of the concrete in general

Клинико-лабораторные особенности течения Крым-Конго геморрагической лихорадки в Узбекистане

Objective: In this research, the clinical and laboratory characteristics of Crimean-Congo hemorrhagic fever (CCHF) in Uzbekistan were studied. The study is considered useful for prevention and case detection, especially in condition of limited sources.Materials and Methods: This study was aimed to determine the clinical and laboratory characteristics of 81 confirmed cases of CCHF among patients who were admitted to infectious diseases hospitals in Uzbekistan from June 2011 to June 2018. The results of this study are based on a retrospective analysis of all confirmed patients.Results: 81 patients with CCHF confirmed by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) methods were examined. The research participants were mainly rural residents – 73 people (90%), 7 people from cities (8.5%), 1 person (1.5%) – a resident of the capital – Tashkent. The age of the patients ranged from 14 to 66 years, with an average of 35.9 ± 12.4 years. 39.5% (32 people) of the participants were women, the remaining 60.5% (49 people) were men. Mortality was 23% (19 patients) with an insignificant difference between men and women (p = 0.8). Most cases were reported from June to September.Conclusion: The occurrence of CCHF among rural residents once again confirms the geographical features and focal nature of the infection. The high contagiousness of the disease is demonstrated by the infection of medical workers, due to the close contact of staff with patients.We did not note the significant relationship between mortality and the period from the onset of the disease to hospitalization. However, there was a strong correlation of mortality with the days of hospital stay, with the blood clotting time and with the level of consciousness of patients.Цель: изучение клинических и лабораторных особенностей Крым-Конго геморрагической лихорадки в Узбекистане, которые могут быть полезны для профилактики и выявления случаев, особенно в условиях ограниченных ресурсов.Материалы и методы: это исследование было направлено на изучение клинических и лабораторных характеристик 81 подтверждённого случая Крым-Конго геморрагической лихорадки среди пациентов, которые были госпитализированы в инфекционные стационары Узбекистана с июня 2011 г. по июнь 2018 г. Результаты настоящего исследования основаны на ретроспективном анализе всех подтверждённых пациентов.Результаты: обследован 81 пациент с Крым-Конго геморрагической лихорадкой, подтверждённой методами иммуноферментного анализа и полимеразно-цепной реакции. Участниками исследования, в основном, были сельские жители – 73 человека (90%), 7 человек из городов (8,5%), 1 человек (1,5%) – житель столицы, Ташкента. Возраст пациентов колебался от 14 до 66 лет, в среднем 35,9 ± 12,4 года. 39,5% (32 человека) больных составляли женщины, остальные 60,5% (49 человек) – мужчины. Летальность составила 23% (19 пациентов) с недостоверной разницей между мужчинами и женщинами (p = 0,8). Большинство случаев были зарегистрированы в период с июня по сентябрь.Выводы: Встречаемость Крым-Конго геморрагической лихорадки среди сельских жителей еще раз подтверждает географические особенности и очаговый характер инфекции. Высокая контагиозность заболевания продемонстрирована инфицированием медицинских работников в связи с плотным контактом персонала с больными.Мы не отметили зависимость смертности от срока от начала заболевания до госпитализации. Однако имелась строгая корреляция смертности с днями пребывания в стационаре, со временем свёртываемости крови и с уровнем сознания пациентов

Clinical Signs and Medical History as Predictors of Enalapril-Associated Dry Cough in Cardiovascular Patients

Angiotensin-converting enzyme inhibitors (ACEIs) are among the most prescribed and effective medicinal products for the treatment of several cardiovascular diseases. According to a number of studies, 30% of patients taking ACEIs develop adverse drug reactions (ADRs), and treatment discontinuation is often required as a result. The most common ADR associated with ACEIs is a dry (non-productive) cough. Nevertheless, the clinical signs and medical history predictive of this ADR in cardiovascular patients are still understudied.The aim of the study was to analyse the clinical signs and medical history predictive of cough in patients with cardiovascular conditions treated with enalapril.Materials and methods. The study was carried out in 2019–2022 and enrolled 224 patients with essential hypertension (grades 2 and 3) treated with enalapril at a dose of 10–20 mg/day. The patients were assigned to 2 groups: Group 1 included 113 patients with enalapril-associated cough, while Group 2 (control group) comprised 104 patients without this ADR. At screening, all the patients underwent a general examination and a check of their allergy and medication history. Using the data obtained, the authors analysed the association of the clinical signs and medical history with the ADR of interest (dry cough).Results. In contrast to the control group, the group with ACEI-associated dry cough included more patients with a history of drug-induced toxicoderma (OR=5.639, CI 2.234–14.236, χ2=15.845, and p<0.001) or type 2 diabetes mellitus (OR=3.409, CI 1.461–7.953, χ2=8.7472, and p<0.01), a family history of bronchial asthma (OR=4.141, CI 2.066–8.299, χ2=17.417, and p<0.001), and a close family history of severe allergic reactions (OR=3.714, CI 1.720– 8.018, χ2=12.137, and p<0.001).Conclusions. A family history of allergy increases the probability of dry cough in patients taking ACEIs. In order to improve the safety of ACEI therapy, patients with cardiovascular conditions should be asked more detailed questions about their personal or first-degree family history of allergy