PENENTUAN KANDUNGAN TOTAL FLAVONOID DAN TOTAL FENOL DARI AKAR KERSEN (Mutingia calabura) SERTA AKTIVITASNYA SEBAGAI ANTIOKSIDAN

Penelitian ini bertujuan untuk mengetahui kadar fenol dan flavonoid total dari ekstrak akar kersen serta aktivitas antioksidannya. Hasil ekstraksi 1 kg akar kersen menghasilkan ekstrak etanol (30,56 g), kloroform (6,52 g), etilasetat (6,1 g), n-butanol (3,21 g) dan air (4,65 g). Penapisan fitokimia menunjukkan ekstrak yang positif flavonoid adalah ekstrak air, kloroform, etanol dan etil asetatsedangkankelimaekstrak tersebut positif mengandung polifenol.  Ekstrak etanol, n-butanol, kloroform, etil asetat, dan air memiliki kandungan total fenol berturut-turut yaitu 12,62%, 3,81%, 6,12%, 8,75%, dan 11,93%. Kandungan flavonoid pada ekstrak etanol, kloroform, etil asetat, dan air berturut-turut yaitu 0,22%, 0,05%, 0,12%, dan 0,03%. Aktivitas antioksidan pada ekstrak etanol diukur dengan metode DPPH dan dinyatakan dengan nilai IC50 sebesar 36,44 pp

The Bali bombs and the tourism development cycle

This paper analyses the impact of the Bali bombings on international visitor arrivals in Bali and compares this crisis with previous crises with reference to Butler’s hypothetical tourism area life cycle. The paper demonstrates that the Bali bombings had by far the greatest impact on international tourism visitation than any other crisis in the island’s history. Such was the severity of the decline in Bali that both national and local measures were taken to restore confidence. Important though these measures were, they do not fully account for the strong resurgence in international arrivals, suggesting that the destination has not yet reached consolidation in accordance with Butler’s hypothesis and that the strength of the resurgence owes much to the underlying trend of the development phase associated with the general picture proposed by Butler

Risk Factor of Mortality Among Covid-19 Infected Doctor in East Java, Indonesia

Introduction: The report of doctors who died with COVID-19 in Indonesia was high and influenced by several factors. This study examined COVID-19 infected doctors and mortality risk factors in East Java. Material and Methods: This observational cohort study was conducted among doctors infected with COVID-19 in East Java during March 2020-September 2021 and collected the COVID-19 infected doctors' deaths report. Doctors received a questionnaire on the status of COVID-19, history of covid-19 infection, age, sex, type of doctor, type of specialization and resident, pregnancy, underlying disease and nutritional status. All data were described and potential risk factors' association was analyzed. Results: We reported 2041 doctors infected with COVID-19. Majority of them (52,5%) was male, 162 doctors were more than 59 years old, 162 doctors (7,9%) were died and 41,4% was general practitioner. The odds ratio in each risk factor for mortality was older age doctors 15,468 (95% CI 10,587-22,601), male 6,128 (95% CI 3,906-9,614), general practitioner 2,461 (95% CI 1,769-3,423), doctors with underlying disease 39,842 (95% CI 23,077-68,798), Type II diabetes mellitus 82,504 (95% CI 42,767-159,162), cardiovascular disease 50,152 (95% CI 16,672-150,866), hypertension 19,425 (95% CI 10,528-35,840), Chronic Obstructive Pulmonary Disease 5,52 (95% CI 0,610-49,992), Asthma 2,091 (95% CI 0,626-6,986), Obesity 30.750 (95% CI 15,293-61,828) and Pregnant doctors 43.013 (95% CI 10.986-168.414) (p<0,05). Conclusion: Older age, male, general practitioner, doctors with underlying disease, cardiovascular disease, Type II diabetes mellitus, hypertension, chronic obstructive pulmonary disease, asthma, obesity, pregnant doctors had been mortality risk factors among COVID-19 infected doctors

An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease

Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts. Methods: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed various aspects of pediatric MAFLD, including epidemiology, mechanisms, screening, and management. Findings: In round 1, we received 65 surveys from 35 countries and analyzed these results, which informed us that 73.3% of respondents agreed with 20 draft statements while 23.8% agreed somewhat. The mean percentage of agreement or somewhat agreement increased to 80.85% and 15.75%, respectively, in round 2. The final statements covered a wide range of topics related to epidemiology, pathophysiology, and strategies for screening and managing pediatric MAFLD. Conclusions: The consensus statements and recommendations developed by an international expert panel serve to optimize clinical outcomes and improve the quality of life for children and adolescents with MAFLD. These findings emphasize the need for standardized approaches in diagnosing and treating pediatric MAFLD. Funding: This work was funded by the National Natural Science Foundation of China (82070588, 82370577), the National Key R&D Program of China (2023YFA1800801), National High Level Hospital Clinical Research Funding (2022-PUMCH-C-014), the Wuxi Taihu Talent Plan (DJTD202106), and the Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021007)