Current distribution inside Py/Cu lateral spin-valve device

We have investigated experimentally the non-local voltage signal (NLVS) in the lateral permalloy (Py)/Cu/Py spin valve devices with different width of Cu stripes. We found that NLVS strongly depends on the distribution of the spin-polarized current inside Cu strip in the vicinity of the Py-detector. To explain these data we have developed a diffusion model describing spatial (3D) distribution of the spin-polarized current in the device. The results of our calculations show that NLVS is decreased by factor of 10 due to spin flip-scattering occurring at Py/Cu interface. The interface resistivity on Py/Cu interface is also present, but its contribution to reduction of NLVS is minor. We also found that most of the spin-polarized current is injected within the region 30 nm from Py-injector/Cu interface. In the area at Py-detector/Cu interface, the spin-polarized current is found to flow mainly close on the injector side, with 1/e exponential decay in the magnitude within the distance 80 nm.Comment: 10 pages, 14 figure

Electron Transport in Hybrid Ferromagnetic/Superconducting Nanostructures

We observe large amplitude changes in the resistance of ferromagnetic (F) wires at the onset of superconductivity of adjacent superconductors (S). New sharp peaks of large amplitude are found in the magnetoresistance of the F-wires. We discuss a new mechanism for the long-range superconducting proximity effect in F/S nanostructures based on the analysis of the topologies of actual Fermi-surfaces in ferromagnetic metals.Comment: 7 pages in LaTeX, 5 eps figures. Submitted to the Proceedings of MS200

Direct demonstration of decoupling of spin and charge currents in nanostructures

The notion of decoupling of spin and charge currents is one of the basic principles underlying the rapidly expanding feld of Spintronics. However, no direct demonstration of the phenomenon exists. We report a novel measurement, in which a non-equilibrium spin population is created by a point-like injection of current from a ferromagnet across a tunnel barrier into a one dimensional spin channel, and detected differentially by a pair of ferromagnetic electrodes placed symmetrically about the injection point. We demonstrate that the spin current is strictly isotropic about the injection point and, therefore, completely decoupled from the uni-directional charge current.Comment: 13 pages, 3 figures; accepted for publication in Nano Letter

Delicate Balance Between Regulation and Stimulation at the Antigen Presenting Cell Site Determines the Likelihood of Successful In-Vitro Priming and Enrichment of Leukemia-Reactive T Cells From the NaïVe Donor Repertoire

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Non-equilibrium supercurrent through mesoscopic ferromagnetic weak links

We consider a mesoscopic normal metal, where the spin degeneracy is lifted by a ferromagnetic exchange field or Zeeman splitting, coupled to two superconducting reservoirs. As a function of the exchange field or the distance between the reservoirs, the supercurrent through this device oscillates with an exponentially decreasing envelope. This phenomenon is similar to the tuning of a supercurrent by a non-equilibrium quasiparticle distribution between two voltage-biased reservoirs. We propose a device combining the exchange field and non-equilibrium effects, which allows us to observe a range of novel phenomena. For instance, part of the field-suppressed supercurrent can be recovered by a voltage between the additional probes.Comment: 7 pages, 8 figures, Europhys. Lett., to be published, corrected two reference

High CD33-antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin |(Mylotarg®) treatment in acute myeloid leukemia patients

Gemtuzumab ozogamicin (Mylotarg®) induces remission in approximately 30% of relapsed AML patients. We previously demonstrated that gemtuzumab infusion results in near-complete CD33 saturation in peripheral blood, and that saturating gemtuzumab levels result in continuous binding and internalization of gemtuzumab due to renewed CD33 expression. We now demonstrate that a high CD33-antigen load in peripheral blood is an independent adverse prognostic factor, likely due to peripheral consumption of gemtuzumab. Indeed, CD33 saturation in bone marrow is significantly reduced (40-90% saturation) as compared with CD33 saturation in corresponding peripheral blood samples (>90%). In vitro, such reduced CD33 saturation levels were strongly related with reduced cell kill. Apparently, high CD33-antigen loads in blood consume gemtuzumab and thereby limit its penetration into bone marrow. Consequently, CD33 saturation in bone marrow is reduced, which hampers efficient cell kill. Therefore, gemtuzumab should be administered at higher or repeated doses, or, preferably, after reduction of the leukemic cell burden by classical chemotherapy

Spin Precession and Oscillations in Mesoscopic Systems

We compare and contrast magneto-transport oscillations in the fully quantum (single-electron coherent) and classical limits for a simple but illustrative model. In particular, we study the induced magnetization and spin current in a two-terminal double-barrier structure with an applied Zeeman field between the barriers and spin disequilibrium in the contacts. Classically, the spin current shows strong tunneling resonances due to spin precession in the region between the two barriers. However, these oscillations are distinguishable from those in the fully coherent case, for which a proper treatment of the electron phase is required. We explain the differences in terms of the presence or absence of coherent multiple wave reflections.Comment: 9 pages, 5 figure

Extremely long quasiparticle spin lifetimes in superconducting aluminium using MgO tunnel spin injectors

There has been an intense search in recent years for long-lived spin-polarized carriers for spintronic and quantum-computing devices. Here we report that spin polarized quasi-particles in superconducting aluminum layers have surprisingly long spin-lifetimes, nearly a million times longer than in their normal state. The lifetime is determined from the suppression of the aluminum's superconductivity resulting from the accumulation of spin polarized carriers in the aluminum layer using tunnel spin injectors. A Hanle effect, observed in the presence of small in-plane orthogonal fields, is shown to be quantitatively consistent with the presence of long-lived spin polarized quasi-particles. Our experiments show that the superconducting state can be significantly modified by small electric currents, much smaller than the critical current, which is potentially useful for devices involving superconducting qubits