67 research outputs found
Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain
Sphingosine-1-phosphate (S1P) is a key regulator of immune response. Immune cells, epithelia and blood cells generate high levels of S1P in inflamed tissue. However, it is not known if S1P acts on the endings of nociceptive neurons, thereby contributing to the generation of inflammatory pain. We found that the S1P1 receptor for S1P is expressed in subpopulations of sensory neurons including nociceptors. Both S1P and agonists at the S1P1 receptor induced hypersensitivity to noxious thermal stimulation in vitro and in vivo. S1P-induced hypersensitivity was strongly attenuated in mice lacking TRPV1 channels. S1P and inflammation-induced hypersensitivity was significantly reduced in mice with a conditional nociceptor-specific deletion of the S1P1 receptor. Our data show that neuronally expressed S1P1 receptors play a significant role in regulating nociceptor function and that S1P/S1P1 signaling may be a key player in the onset of thermal hypersensitivity and hyperalgesia associated with inflammation
Inclusive ee production in collisions of pions with protons and nuclei in the second resonance region of baryons
Inclusive ee production has been studied with HADES in + p,
+ C and reactions, using the GSI pion beam at
= 1.49 GeV. Invariant mass and transverse momentum
distributions have been measured and reveal contributions from Dalitz decays of
, mesons and baryon resonances. The transverse momentum
distributions are very sensitive to the underlying kinematics of the various
processes. The baryon contribution exhibits a deviation up to a factor seven
from the QED reference expected for the dielectron decay of a hypothetical
point-like baryon with the production cross section constrained from the
inverse n p reaction. The enhancement is attributed
to a strong four-momentum squared dependence of the time-like electromagnetic
transition form factors as suggested by Vector Meson Dominance (VMD). Two
versions of the VMD, that differ in the photon-baryon coupling, have been
applied in simulations and compared to data. VMD1 (or two-component VMD)
assumes a coupling via the meson and a direct coupling of the photon,
while in VMD2 (or strict VMD) the coupling is only mediated via the
meson. The VMD2 model, frequently used in transport calculations for dilepton
decays, is found to overestimate the measured dielectron yields, while a good
description of the data can be obtained with the VMD1 model assuming no phase
difference between the two amplitudes. Similar descriptions have also been
obtained using a time-like baryon transition form factor model where the pion
cloud plays the major role.Comment: (HADES collaboration
Magnesium deficiency decreases biomass water-use efficiency and increases leaf water-use efficiency and oxidative stress in barley plants
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons
Neuro-electronic systems towards tissue implantation by neural grafting: The EC-Biomed2 NESTING project.
Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer.
BACKGROUND:
Pancreatic cancer is one of the leading causes of cancer-related death. Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines.
METHODS:
We analyzed the gene expression of 5 established pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2 and HPAF II) and 5 primary isolates, 1 of them derived from benign pancreatic duct cells.
RESULTS:
Out of 1,540 genes which were expressed in at least 3 experiments, we found 122 genes upregulated and 18 downregulated in tumor cell lines compared to benign cells with a fold change >3. Several of the upregulated genes (like Prefoldin 5, ADAM9 and E-cadherin) have been associated with pancreatic cancer before. The other differentially regulated genes, however, play a so far unknown role in the course of human pancreatic carcinoma. By means of immunohistochemistry we could show that thymosin beta-10 (TMSB10), upregulated in tumor cell lines, is expressed in human pancreatic carcinoma, but not in non-neoplastic pancreatic tissue, suggesting a role for TMSB10 in the carcinogenesis of pancreatic carcinoma
Report and preliminary results of METEOR-Cruise M 38/1, Las Palmas - Recife, 25.1.-1.3.1997 With appendix: core descriptions: METEOR-Cruise M 37/1
SIGLEAvailable from TIB Hannover: RO 7630(94) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Chemical Hydrolysis of Some Organic Phosphorus and Carbamate Pesticides in Aquatic Environments
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