13 research outputs found
DeepTract: A Probabilistic Deep Learning Framework for White Matter Fiber Tractography
We present DeepTract, a deep-learning framework for estimating white matter
fibers orientation and streamline tractography. We adopt a data-driven approach
for fiber reconstruction from diffusion weighted images (DWI), which does not
assume a specific diffusion model. We use a recurrent neural network for
mapping sequences of DWI values into probabilistic fiber orientation
distributions. Based on these estimations, our model facilitates both
deterministic and probabilistic streamline tractography. We quantitatively
evaluate our method using the Tractometer tool, demonstrating competitive
performance with state-of-the art classical and machine learning based
tractography algorithms. We further present qualitative results of
bundle-specific probabilistic tractography obtained using our method. The code
is publicly available at: https://github.com/itaybenou/DeepTract.git
Do size and unobservable company factors explain stock price reversals?
Price reversal, Small Firm, Fixed Effects, Unobservable, G14,
Empirical Investigation of the Relationship between the Operational Competence of Service Providers and the Use andAdoption of Mobile Commerce
Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy
In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have been implicated in its progress. In this study, we report a functional interaction between macroautophagy and Corticotropin Releasing Hormone (Crh) in the gut. For this purpose we used DSS colitis model on Crh ?/? or wild-type (wt) with pharmacological inhibition of autophagy. We uncovered sustained basal autophagy in the gut of Crh ?/? mice, which persisted over the course of DSS administration. Autophagy inhibition resulted in partial rescue of Crh ?/? mice, while it increased the expression of Crh in the wt gut. Similarly, Crh deficiency was associated with sustained activation of base line autophagy. In vitro models of amino acid deprivation- and LPS-induced autophagy confirmed the in vivo findings. Our results indicate a novel role for Crh in the intestinal epithelium that involves regulation of autophagy, while suggesting the complementary action of the two pathways. These data suggest the intriguing possibility that targeting Crh stimulation in the intestine may provide a novel therapeutic approach to support the integrity of the epithelial barrier and to protect from chronic colitis