Factors Affecting Human Papillomavirus Vaccination in Men: Systematic Review

BackgroundDespite the high risks associated with human papillomavirus (HPV), the HPV vaccination rate of men is far lower than women. Most previous review studies have focused on female vaccination and related affecting factors. However, previous studies have reported that the factors affecting HPV vaccination differ by gender. ObjectiveThe aim of this review was to identify the factors affecting HPV vaccine initiation in men through a systematic review approach. MethodsA literature review was conducted across 3 central electronic databases for relevant articles. A total of 30 articles published between 2013 and 2019 met the inclusion criteria and were reviewed in this study. ResultsIn total, 50 factors affecting HPV vaccination in men were identified, including 13 sociodemographic factors and social structure factors, 12 belief-related variables, 4 family factors, 4 community factors, 14 variables related to needs, and 3 environmental factors. ConclusionsTo increase HPV vaccination rates in men, strategies targeting young males and their families should consider frequent visits to or contact with health care providers so that health care professionals can provide recommendations for HPV vaccination

Peptide Specific Nanoplastic Detection Based on Sandwich Typed Localized Surface Plasmon Resonance

Recently, various waste microplastics sensors have been introduced in response to environmental and biological hazards posed by waste microplastics. In particular, the detrimental effects of nano-sized plastics or nanoplastics have been reported to be severe. Moreover, there have been many difficulties for sensing microplastics due to the limited methodologies for selectively recognizing nanoplastics. In this study, a customized gold nanoparticles (Au NPs) based localized surface plasmon resonance (LSPR) system having bio-mimicked peptide probes toward the nanoplastics was demonstrated. The specific determination through the oligo-peptide recognition was accomplished by chemical conjugation both on the LSPR chip’s 40~50 nm Au NPs and sandwiched 5 nm Au NPs, respectively. The peptide probe could selectively bind to polystyrene (PS) nanoplastics in the forms of fragmented debris by cryo-grinding. A simple UV-Vis spectrophotometer was used to identify the LSPR sensing by primarily measuring the absorbance change and shift of absorption peak. The sandwich-binding could increase the LSPR detection sensitivity up to 60% due to consecutive plasmonic effects. In addition, microwave-boiled DI water inside of a styrofoam container was tested for putative PS nanoplastics resource as a real accessible sample. The LSPR system could be a novel protocol overcoming the limitations from conventional nanoplastic detection

Steric Effect on the Nucleophilic Reactivity of Nickel(III) Peroxo Complexes

A set of nickel(III) peroxo complexes bearing tetraazamacrocyclic ligands, [Ni-III(TBDAP)(O-2)](+) (TBDAP = N,Ni-di-tert-butyl-2,11-diaza[3.3](2,6)pyridinophane) and [Ni-III(CHDAP)(O-2)](+) (CHDAP = N,N'-dicyclohexyl-2,11-diaza[3.3](2,6)pyridinophane), were prepared by reacting [Ni-II(TBDAP)(NO3)(H2O)](+) and [Ni-II(CHDAP)(NO3)](+), respectively, with H2O2 in the presence of triethylamine. The mononuclear nickel(III) peroxo complexes were fully chatacterized by various physicochemical methods, such as UV-vis, electrospray ionization mass spectrometry, resonance Raman, electron paramagnetic resonance, and X-ray analysis. The spectroscopic and structural characterization clearly shows that the NiO2 cores are almost identical where the peroxo ligand is bound in a side-on fashion. properties of the supporting ligands were confirmed by X-ray crystallography, where the CHDAP ligand gives enough space around the Ni core compared to the TBDAP ligand. The nickel(III) peroxo complexes showed reactivity in the oxidation of aldehydes. In the aldehyde deformylation reaction, the nucleophilic reactivity of the nickel(III) peroxo, complexes was highly dependent on the steric properties of the macrocyclic ligands, with. a reactivity order of [Ni-III(TBDAP)(O-2)](+) < [Ni-III(CHDAP)(O-2)](+). This result provides fundamental insight into the mechanism of the structure (steric) reactivity relationship of metal peroxo intermediates

Activation of Hypoxia-Inducible Factor-1α Signaling Pathway Has the Protective Effect of Intervertebral Disc Degeneration

Intervertebral discs (IVDs) have poor nutrient diffusion, because the nucleus pulposus (NP) lacks direct vascular supply and likely generates adenosine triphosphate by anaerobic glycolysis. Regulation of glycolysis is mediated by hypoxia-inducible factor-1α (HIF-1α), a transcription factor that responds to local oxygen tension. Constitutively active HIF-1α (CA HIF-1α) was created by point mutation and determined the protective role of HIF-1α in IVD degeneration. Under fluoroscopy, rat caudal IVD segments were stabbed by a needle puncture, and pcDNA3- HIF-1α wild-type (WT) or pcDNA3-CA HIF-1α was transfected into NP cell lines. The constitutive activity of CA HIF-1α was analyzed using a luciferase assay after cell lysis. Next, IVD tissue samples were retrieved from five patients with degenerative lumbar spinal stenosis at the time of surgery, and NP cells were cultured. NP cells were transfected with CA HIF-1α, and relevant gene expression was measured. HIF-1α protein levels in the nucleus were significantly higher, and transcriptional activity was 10.3-fold higher in NP cells with CA HIF-1α than in those with HIF-1α WT. Gene transfer of CA HIF-1α into NP cells enhanced the expression of Glut-1, Glut-3, aggrecan, type II collagen, and Sox9. Moreover, CA HIF-1α reduced the apoptosis of NP cells induced by the Fas ligand. The HIF-1α and collagen 2 expression levels were notably increased in the NP cells of the CA HIF-1α transfected segments in histology and immunohistochemistry study. Collectively, these results suggest that activation of HIF-1α signaling pathway may play a protective role against IVD degeneration and could be used as a future therapeutic agent

Nanoscale Electrical Probes on a Single Facet of a ZnO Microwire: Device Fabrication and Local Electrical Characteristics

The electrical properties of a single facet of an individual ZnO microwire were investigated. Electrode patterns with a Hall bar structure were deposited on the surface of the top facet of the ZnO microwire. Using a suspended and cross-linked poly(methyl methacrylate) ribbon structure, it was possible to define the electrical connections only at the top surface, while avoiding those on the other five sides of the ZnO microwire. Current-voltage characteristics were examined, and Hall measurements were conducted with various magnetic fields. Through our device structure, the electrical properties could be directly probed at specific points on the ZnO surface in a reliable manner. The estimated electrical characteristics demonstrate that the carrier concentration and mobility of the ZnO surface varied along the axial direction of the wire. These results indicate that the charge carrier concentration on the surface of the micro-/nanowire can be sensitively changed according to the synthesis environment. In addition, it is worth noting that the nanoscale local Hall probes, fabricated by our technique, could probe the very slight variation of carrier concentration, which is difficult to detect by a standard transport measurement along the wire.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QN/Steeneken La

Measurements of 89Y(n,2n)88Y and 89Y(n,3n)87Y, 87mY cross sections for fast neutrons at KIRAMS

A proton cyclotron MC-50 in Korea Institute of Radiological & Medical Science (KIRAMS) is used to carry out neutron activation experiments with Y2O3 targets irradiated with neutron beams of a continuous spectrum produced by proton beams on a thick beryllium target. Neutrons are generated by 9Be (p, n) reaction with an incident proton intensity of 20 μA. The neutron spectra generated by proton beams of 30, 35, and 40 MeV are calculated by GEANT4 simulations. Nb powders are used for neutron flux monitoring by measuring the activities of 92mNb through the reaction 93Nb (n, 2n). By using a subtraction method, the average cross section of 89Y(n,2n) and 89Y(n,3n) reactions at the neutron energies of 29.8 ± 1.8 MeV and 34.8 ± 1.8 MeV are extracted and are found to be close to the existing cross sections from the EXFOR data and the evaluated nuclear data libraries such as TENDL-2015 or EAF-2010

Measurements of cross sections for the

We measured 209Bi(n, 4n) cross sections at neutron energies En = 29.8 ± 1.8 MeV and En = 34.8 ± 1.8 MeV. Bismuth oxide samples were irradiated with the neutrons produced by impinging 30, 35 and 40 MeV proton beams on a 1.05 cm thick beryllium target, where the proton beams were from the MC-50 Cyclotron of Korea Institute of Radiological Medical Sciences (KIRAMS). The neutron flux for each proton beam energy Ep, ΦEp(En), has a broad spectrum with respect to En. By taking the difference in the neutron fluxes, the difference spectra, Φ40(En) −Φ35(En) and Φ35(En) −Φ30(En), are obatined and found to be peaked at En = 29.8 and 34.8 MeV, respectively, with a width of about 3.6 MeV. By making use of this observation and employing the TENDL-2009 library we could extract the 209Bi(n, 4n)206Bi cross sections at the aforementioned neutron energies