Risk of “silent stroke” in patients older than 60 years: risk assessment and clinical perspectives

With the increasing size of the elderly population and evolving imaging technology, silent brain infarction (SBI) has garnered attention from both the public and the physicians. Over 20% of the elderly exhibit SBI, and the prevalence of SBI increases steadily with age, ie, 30%–40% in those older than 70 years. Well-known cardiovascular risk factors such as hypertension has been identified as a risk factor of SBI (odds ratio [OR] = 3.47) Besides this, blood pressure (BP) reactivity to mental stress, morning BP surges, and orthostatic BP changes have been demonstrated to contribute to the presence of SBI. Further, a metabolic syndrome not only as a whole syndrome (OR =2.18) but also as individual components could have an influence on SBI. Increased C-reactive protein and interleukin-6, coronary artery disease, body mass index, and alcohol consumption have also been associated with SBI. The ORs and possible mechanisms have been discussed in this article. Overt stroke, dementia, depression, and aspiration pneumonia were all associated with SBI. (overt stroke: hazard ratio [HR] =1.9, 95% confidence interval [CI]: 1.2–2.8; dementia: HR =2.26, 95% CI: 1.09–4.70). We also looked into their close relationship with SBI in this review

Minimax particle filtering for tracking a highly maneuvering target

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152473/1/rnc4785_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152473/2/rnc4785.pd

Failure mechanisms of layered LiNixCoyMn1-x-yO2 cathodes for Li-ion batteries

Department of Energy Engineering (Battery Science and Technology)As the promising cathode material, Ni-containing layered Li NCM oxide has several advantages; low-cost, high capacity, etc. but hard to commercialize because of its poor cycle performance. About this, many researchers studied the failure mechanisms and regard the surface part problems as the failure mechanism of layered LI NCM oxide. However, apart from surface part problem, there are other failure mechanisms affect to the poor cycle performance of Li NCM. Among them, we focus and suggest new kinds of failure mechanism; Ni disordering as bulk part problem. To identify, at first, the half cell test shows that the poor cycle performance of Li NCM in several factors, and the degree of Ni disordering during cycling is analyzed using Rietveld refinement method. As results, when the Ni disordering is increased during cycling, the capacity of Li NCM is decreased more and more, and this indicates that Ni disordering can affect the cycle performance of Li NCM during cycling, so it is demonstrated that the Ni disordering is one of the failure mechanism of poor cycle performance of layered LI NCM. Moreover, we suggest new type solution to improve; Mg doping at Li layer of Li NCM. Several analyses, such as TEM, refinement data show the Mg is successfully doped into Li layer, and the half cell test shows its better cycle performance than bare Li NCM (1C, 30℃). Also, through refinement analysis of cycled Mg-doped Li NCM electrode, we observe that the Ni disordering is also inhibited somewhat, comparing the bare Li NCM results.ope

The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission

Genes and neural circuits coordinately regulate animal sleep. However, it remains elusive how these endogenous factors shape sleep upon environmental changes. Here, we demonstrate that Shaker (Sh)-expressing GABAergic neurons projecting onto dorsal fan-shaped body (dFSB) regulate temperature-adaptive sleep behaviors in Drosophila. Loss of Sh function suppressed sleep at low temperature whereas light and high temperature cooperatively gated Sh effects on sleep. Sh depletion in GABAergic neurons partially phenocopied Sh mutants. Furthermore, the ionotropic GABA receptor, Resistant to dieldrin (Rdl), in dFSB neurons acted downstream of Sh and antagonized its sleep-promoting effects. In fact, Rdl inhibited the intracellular cAMP signaling of constitutively active dopaminergic synapses onto dFSB at low temperature. High temperature silenced GABAergic synapses onto dFSB, thereby potentiating the wake-promoting dopamine transmission. We propose that temperature-dependent switching between these two synaptic transmission modalities may adaptively tune the neural property of dFSB neurons to temperature shifts and reorganize sleep architecture for animal fitness. Ji-hyung Kim and Yoonhee Ki et al. show that low temperatures suppress sleep in Drosophila by increasing GABA transmission in Shaker-expressing GABAergic neurons projecting onto the dorsal fan-shaped body, while high temperatures potentiate dopamine-induced arousal by reducing GABA transmission. This study highlights a role for Shaker in sleep modulation via a temperature-dependent switch in GABA signaling

Service Negotiation Model for Response Time in Distributed Networks

The important thing of QoS is that response time of service is transparently suggested to resource management system and network users. This helps to schedule jobs or guarantee the service level agreement. This paper proposes to specify a negotiation policy for response time of distributed network using network latency function. To monitor and manage service response time in distributed network, we identified the relationships between network/application performance and QoS parameters. We also provided the statistical analysis on mapping user level response time to application and network level parameters. To show the validation of the network latency function, we used the NS-2 network simulator and showed the efficiency of that function. Finally we suggested the negotiation of policy for response time of requested service