Progressive evolution of tunneling characteristics of in-situ fabricated intrinsic Josephson junctions in Bi_2Sr_2CaCu_2O_{8+delta} single crystals

Stacks of a few intrinsic tunnel junctions were micro-fabricated on the surface of Bi-2212 single crystals. The number of junctions in a stack was tailored by progressively increasing the height of the stack by ion-beam etching, while its tunneling characteristics were measured in-situ in a vacuum chamber for temperatures down to ~13 K. Using this in-situ etching/measurements technique in a single piece of crystal, we systematically excluded any spurious effects arising from variations in the junction parameters and made clear analysis on the following properties of the surface and inner conducting planes. First, the tunneling resistance and the current-voltage curves are scaled by the surface junction resistance. Second, we confirm that the reduction in both the gap and the superconducting transition temperature of the surface conducting plane in contact with a normal metal is not caused by the variation in the doping level, but is caused by the proximity contact. Finally, the main feature of a junction is not affected by the presence of other junctions in a stack in a low bias region.Comment: 25 pages, 7 figures, submitted to Phys. Rev.

Adiabatic Electroweak Baryogenesis Driven by an Axion-like Particle

An axion-like particle (ALP) offers a new direction in electroweak baryogenesis because the periodic nature enables it to trigger a strong first-order phase transition insensitively to the decay constant $f$. For $f$ much above TeV, the ALP-induced electroweak phase transition is approximately described by adiabatic processes, distinguishing our scenario for electroweak baryogenesis from the conventional ones. We show that, coupled to the electroweak anomaly, the ALP can naturally realize spontaneous electroweak baryogenesis to solve the matter-antimatter asymmetry problem for $f$ in the range between about $10^5$ GeV and $10^7$ GeV. In such an ALP window, the $CP$ violation for baryogenesis is totally free from the experimental constraints, especially from the recently improved limit on the electron electric dipole moment. Future searches for ALPs could probe our scenario while revealing the connection between electroweak symmetry breaking and baryogenesis.Comment: 12 pages, 5 figures, appendices added, published versio

Suppressed Superconductivity of the Surface Conduction Layer in Bi2_2Sr2_2CaCu2_2O8+x_{8+x} Single Crystals Probed by {\it c}-Axis Tunneling Measurements

We fabricated small-size stacks on the surface of Bi$_2$Sr$_2$CaCu$_2$O$_{8+x}$ (BSCCO-2212) single crystals with the bulk transition temperature $T_c$$\simeq$90 K, each containing a few intrinsic Josephson junctions. Below a critical temperature $T_c'$ ($\ll$ $T_c$), we have observed a weakened Josephson coupling between the CuO$_2$ superconducting double layer at the crystal surface and the adjacent one located deeper inside a stack. The quasiparticle branch in the $IV$ data of the weakened Josephson junction (WJJ) fits well to the tunneling characteristics of a d-wave superconductor($'$)/insulator/d-wave superconductor (D$'$ID) junction. Also, the tunneling resistance in the range $T_c'$$<$$T$$<$$T_c$ agrees well with the tunneling in a normal metal/insulator/d-wave superconductor (NID) junction. In spite of the suppressed superconductivity at the surface layer the symmetry of the order parameter appears to remain unaffected.Comment: 13 pages, 6 figure

An immunohistochemical study of the pancreatic endocrine cells of the ddN mouse.

The regional distribution and frequency of the pancreatic endocrine cells in the ddN mouse were studied using specific antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (hPP). In the pancreatic islets, most of insulin-immunoreactive (IR) cells were located in the central region, and glucagon-, somatostatin and hPP-IR cells were located in the peripheral region regardless of the lobe. In the splenic part, glucagon-IR cells were also located in the central regions, and more numerous somatostatin-IR cells were detected in the central regions as compared with the duo-denal part. hPP-IR cells were restricted to the peripheral regions in both lobes but more numerous cells were detected in the duodenal portion. In the exocrine parenchyma of the splenic lobe, only insulin- and glucagon-IR cells were detected but all four kinds of IR cells were observed in the duodenal portion. In addition, insulin and hPP-IR cells were also demonstrated in the pancreatic duct regions. In conclusion, some strain-dependent characteristic distributional patterns of pancreatic endocrine cells were found in the ddN mouse with somewhat different distributional patterns between the two pancreatic lobes

Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-α and Nitric Oxide Production In Vitro

To verify the anti-inflammatory potency of iridoids, seven iridoid glucosides (aucubin, catalpol, gentiopicroside, swertiamarin, geniposide, geniposidic acid and loganin) and an iridoid aglycone (genipin) were investigated with in vitro testing model systems based on inhibition of cyclooxygenase (COX)-1/-2 enzymes, the tumor necrosis factor-α (TNF-α) formation and nitric oxide (NO) production. The hydrolyzed-iridoid products (H-iridoid) with β-gludosidase treatment only showed inhibitory activities, and revealed different potencies, depending on their chemical structures. Without the β-gludosidase treatment, no single iridoid glycoside exhibited any activities. The aglycone form (genipin) also did not show inhibitory activities. To compare anti-inflammatory potency, the inhibitory concentrations (IC50) in each testing system were measured. The hydrolyzed-aucubin product (H-aucubin) with β-gludosidase treatment showed a moderate inhibition on COX-2 with IC50 of 8.83 μM, but much less inhibition (IC50, 68.9 μM) on COX-1 was noted. Of the other H-iridoid products, the H-loganin and the H-geniposide exhibited higher inhibitory effects on COX-1, revealing IC50 values of 3.55 and 5.37 μM, respectively. In the case of TNF-α assay, four H-iridoid products: H-aucubin, H-catalpol, H-geniposide and H-loganin suppressed the TNF-α formation with IC50 values of 11.2, 33.3, 58.2 and 154.6 μM, respectively. But other H-iridoid products manifested no significant activity. Additional experiments on NO production were conducted. We observed that only the H-aucubin exhibited a significant suppression with IC50 value of 14.1 μM. Genipin, an agycone form, showed no inhibitory effects on all testing models, implying the hydrolysis of the glycosidic bond of iridoid glycoside is a pre-requisite step to produce various biological activities

Whole-brain imaging with receive-only multichannel top-hat dipole antenna RF coil at 7 T MRI

This work investigates the construction and performance of an eight-channel top-hat dipole receiver RF coil with a capacitive plate to increase the longitudinal whole-brain coverage and receiver sensitivity gain in the brain at 7 T MRI. The construction method for top-hat dipole-based receiver RF coil by adjusting the length and structure corresponding to each channel consists of tuning, matching, balun, and detuning circuitry. Electromagnetic simulations were analyzed on a 3-D human model to evaluate B1+ efficiency and specific absorption rate deposition. Coil performance was evaluated in the human head imaging in vivo. EM simulation results indicated a higher B1− sensitivity in the brain and z-directional coverage of the proposed eight-channel receiver RF coil. The MR images were acquired with an identical field of view showing the receiver coverage improvement in the brain when capacitive plates are used. The MR images also show the clear visibility of the complete set of the cervical vertebrae as well as the spinal cord. The acquired MRI results demonstrate the capability of the proposed RF coil to increase the receiver coverage in the longitudinal direction. Moreover, the B1+ efficiency, as well as receiver sensitivity in the brain, can be substantially improved with the use of multilayered capacitive plates of proper shape and size in conjunction with an RF coil

Calcium-binding Protein Calretinin Immunoreactivity in the Dog Superior Colliculus

We studied calretinin-immunoreactive (IR) fibers and cells in the canine superior colliculus (SC) and studied the distribution and effect of enucleation on the distribution of this protein. Localization of calretinin was immunocytochemically observed. A dense plexus of anti-­calretinin-IR fibers was found within the upper part of the superficial gray layer (SGL). Almost all of the labeled fibers were small in diameter with few varicosities. The intermediate and deep layers contained many calretinin-IR neurons. Labeled neurons within the intermediate gray layer (IGL) formed clusters in many sections. By contrast, labeled neurons in the deep gray layer (DGL) did not form clusters. Calretinin-IR neurons in the IGL and DGL varied in morphology and included round/oval, vertical fusiform, stellate, and horizontal neurons. Neurons with varicose dendrites were also labeled in the IGL. Most of the labeled neurons were small to medium in size. Monocular enucleation produced an almost complete reduction of calretinin-IR fibers in the SC contralateral to the enucleation. However, many calretinin-IR cells appeared in the contralateral superficial SC. Enucleation appeared to have no effect on the distribution of calretinin-IR neurons in the contralateral intermediate and deep layers of the SC. The calretinin-IR neurons in the superficial dog SC were heterogeneous small- to medium-sized neurons including round/oval, vertical fusiform, stellate, pyriform, and ­horizontal in shape. Two-color immunofluorescence revealed that no cells in the dog SC ­expressed both calretinin and GABA. Many horseradish peroxidase (HRP)-labeled retinal ganglion cells were seen after injections into the superficial layers. The vast majority of the double-labeled cells (HRP and calretinin) were small cells. The present results indicate that antibody to calretinin labels subpopulations of neurons in the dog SC, which do not express GABA. The results also suggest that the calretinin-IR afferents in the superficial layers of the dog SC originate from small class retinal ganglion cells. The expression of calretinin might be changed by the cellular activity of selective superficial collicular neurons. These results are valuable in delineating the basic neurochemical architecture of the dog visual system